An unusual location of gouty panniculitis

Martín, David; Joliat, Gaëtan‐Romain; Fournier, Pierre; Brunel, Christophe; Demartines, Nicolas; Gié, Olivier

doi:10.1097/md.0000000000006733

Cited by 5 publications

(6 citation statements)

References 13 publications

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“…Precipitation of uric acid into monosodium urate (MSU) crystals in joints elicits acute aseptic inflammation, the gouty arthritis, prevalence of which increases with increasing SUA levels 19 . Deposition of MSU crystals can also occur in other tissues and organs in humans, although it is reported seldom 20–22 . Formation of MSU crystals may also occur in the blood from hyperuricemic patients 22 .…”

Section: Introductionmentioning

confidence: 99%

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Crystallized but not soluble uric acid elicits pro-inflammatory response in short-term whole blood cultures from healthy men

Brovold

Lund

Svistounov

et al. 2019

Sci Rep

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Several epidemiological studies have pointed at serum uric acid (SUA) as an independent risk factor for mortality, diabetes, hypertension, cardiovascular and kidney disease; however, no clear pathogenic pathway is established. Uric acid (UA) crystals show pro-inflammatory properties and can thus create or contribute to the state of chronic low-grade inflammation, a widely accepted pathogenic mechanism in several of the above-mentioned pathologies. On the other hand, soluble uric acid possesses antioxidant properties that might attenuate inflammatory responses. We aimed to explore the net effects of experimentally rising SUA in human whole blood cultures on several mediators of inflammation. Production of TNF-α, IL-1ß, IL-1RA, MCP-1 and IL-8 was assessed upon addition of 200 µM UA, 500 µM UA or monosodium urate (MSU) crystals in the presence or absence of 5 ng/ml lipopolysaccharide (LPS). RT-qPCR and multiplex bead based immunoassay were used to measure mRNA expression and cytokine release at 2 and 4 h of culture, respectively. 14 C labeled UA was used to assess intracellular uptake of UA. We show that crystallized, but not soluble, UA induces production of pro-inflammatory mediators in human whole blood. Soluble UA is internalized in blood cells but does not potentiate or reduce LPS-induced release of cytokines.

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Section: Introductionmentioning

confidence: 99%

“…Deposition of MSU crystals can also occur in other tissues and organs in humans, although it is reported seldom 20–22 . Formation of MSU crystals may also occur in the blood from hyperuricemic patients 22 .…”

Section: Introductionmentioning

confidence: 99%

Crystallized but not soluble uric acid elicits pro-inflammatory response in short-term whole blood cultures from healthy men

Brovold

Lund

Svistounov

et al. 2019

Sci Rep

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“…Surgical treatment may be simple as squeezing the pasty tophaceous material and fluid aspiration but sometimes surgical decompression may be needed. Following surgical decompression, pharmacological treatment and lifestyle modifications are of paramount importance (15)(16)(17)(18).…”

Section: Discussionmentioning

confidence: 99%

Rare Location and Clinical Presentation of Gout Disease: Distal Ulna Localized Gout Disease and Acute Gout Attack of the Wrist

Öztürk¹

2020

Clinical and Experimental Health Sciences

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Gout is one of the most common inflammatory arthritis in adults. This disorder is caused by the accumulation of monosodium urate crystals in soft tissues and joints because of the hyperuricemia. One of the lower extremity joint especially the first metatarsophalangeal joint is affected by more than 75% of the gout attacks. In this study, we reported a rare presentation of gout disease, the acute gout attack of the wrist, in a woman, 72 years aged, who has not been diagnosed before. Gout which occurs with the involvement of the wrist is very rare and no other cases with distal ulna localization have been reported according to our knowledge. We reported the first case of gout disease which started from distal ulna. The patient was operated because the symptoms did not recover with conservative treatments.

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“…Antihyperuricemic therapies may provide benefits, and low dose steroids may control the pain and inflammation (13,14). Surgical treatment is indicated in cases refractory to medical therapy and suspected diagnosis (15). Surgical treatment may be simple as squeezing the pasty tophaceous material and fluid aspiration, but sometimes surgical decompression may be needed.…”

Section: Discussionmentioning

confidence: 99%

Psoriasis Related Gout Arthritis In The Big Toe Interphalangeal Joint: A Case Report

Öztürk¹

2020

Acibadem Universitesi Saglik Bilimleri Dergisi

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In this study, we present the first report of a case of gout arthritis localized in the interphalangeal joint of the right foot first toe, which was related to psoriasis disease in a 40-year-old male patient. Since the symptoms did not respond to conservative treatments, the patient was treated with surgery. Arthrotomy was performed to debride around the bones and intraarticular crystals. Then, pharmacological treatment was initiated and lifestyle changes were made. No recurrence of the symptoms was observed during a 24-month follow-up.

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An unusual location of gouty panniculitis

Cited by 5 publications

References 13 publications

Crystallized but not soluble uric acid elicits pro-inflammatory response in short-term whole blood cultures from healthy men

Crystallized but not soluble uric acid elicits pro-inflammatory response in short-term whole blood cultures from healthy men

Rare Location and Clinical Presentation of Gout Disease: Distal Ulna Localized Gout Disease and Acute Gout Attack of the Wrist

Psoriasis Related Gout Arthritis In The Big Toe Interphalangeal Joint: A Case Report

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