An unusual infection after renal transplantation

De, Wilcken; Jd, Mackie; Ba, Pussell; B, Gatus; Dj, Burke; Fj, Palmer; Ba, Warren

doi:10.5694/j.1326-5377.1986.tb139454.x

Cited by 8 publications

(4 citation statements)

References 8 publications

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“…This finding may mean that patients with primary cutaneous mucormycosis will manifest their infection earlier after transplantation than will patients with other forms of the disease. Consistent with this hypothesis, the median time to presentation in this subset of patients was 23 days (range 4–150 days) following transplantation or, in a minority of cases, following intervention (renal biopsy) or injury (Table 1) (8–13, 16, 18–32). In a review of all SOT recipients with mucormycosis, the median time to onset following transplantation was 60 days, but with a wide range from 1 to 2920 days (6).…”

Section: Discussionsupporting

confidence: 67%

Primary cutaneous mucormycosis in a lung transplant recipient: case report and concise review of the literature

Page

Evans²,

Snell

et al. 2008

Transplant Infectious Dis

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Mucormycosis (zygomycosis) is an invasive, opportunistic fungal infection caused by organisms of the class Zygomycetes. Immunocompromised individuals, including both solid organ and hematopoietic stem cell transplant recipients, are preferentially affected. Among solid organ transplant (SOT) recipients, the sinuses, with or without involvement of the orbits and cerebrum, are the most common sites of disease, although the pulmonary allograft appears to be targeted following lung transplantation. Here, we describe the unique case of a lung transplant recipient who developed multifocal cutaneous mucormycosis without involvement of the pulmonary allograft, and review the published literature regarding incidence, treatment, and prognosis of primary cutaneous mucormycosis following SOT.

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Section: Discussionsupporting

confidence: 67%

Primary cutaneous mucormycosis in a lung transplant recipient: case report and concise review of the literature

Page

Evans²,

Snell

et al. 2008

Transplant Infectious Dis

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“…Table 1 summarizes the demographics, clinical presentation, treatment and outcome of the 10 patients. Information from additional 106 patients was added from the literature review (9–92).…”

Section: Resultsmentioning

confidence: 99%

“…Of the 18 cases of cutaneous zygomycosis (n = 18, 15.5%), 8 (44.4%) developed lesions at surgical wounds or drains (13,49,50,59,71,80), 4 (22.2%) at intravenous catheter site (48,52,68,78), 1 (5.5%) at a renal biopsy tract (77), 1 (5.5%) after skin trauma (51) and in 4 (22.2%) there was no history of trauma to the skin or use of adhesive tape (28,32,55,67). Lesions appeared often as black necrotic with surrounding cellulitis, thrombophlebitis or extension to deeper structures.…”

Section: Resultsmentioning

confidence: 99%

Zygomycosis in Solid Organ Transplant Recipients in a Tertiary Transplant Center and Review of the Literature

Almyroudis¹,

Sutton

Linden³

et al. 2006

American Journal of Transplantation

247

254

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Zygomycetes are ubiquitous fungi that can cause invasive disease associated with high mortality. We report 10 solid organ transplant recipients with zygomycosis (incidence 2 per 1000) and reviewed 106 cases in the English-language literature. These included renal (n = 73), heart (n = 16), lung (n = 4), heart/lung (n = 2), liver (n = 19) and kidney/pancreas (n = 2) transplant recipients. All patients were receiving immunosuppression and the vast majority steroids. The clinical presentation included rhino-sino-orbital (n = 20), rhinocerebral (n = 16), pulmonary (n = 28), gastrointestinal (n = 13), cutaneous (n = 18), renal (n = 6) and disseminated disease (n = 15). Most frequently isolated genera were Rhizopus (73%) followed by Mucor (13%). The overall mortality was 49%. While rhino-sino-orbital disease had the best prognosis, rhinocerebral disease had high mortality (93%) comparable to disseminated disease. A favorable outcome was associated with limited, surgically accessible disease and early surgical intervention along with amphotericin B administration.

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“…Although widely described in the transplant literature, cases of limb involvement are rare (3)(4)(5)(6)(7)(8)(9). Our patient was immunocompromised due to sepsis in a patient with chronic liver failure.…”

Section: Discussionmentioning

confidence: 87%

Mucormycosis Infection Following Intravenous Access in the Forearm

Wollstein

Palekar

2010

Canadian Journal of Plastic Surgery

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Mucormycosis is an opportunistic infection that is often fatal, requiring aggressive local control as well as systemic therapy. A rare case of a forearm infection originating in a traumatic intravenous access portal is described in the present study. The Mucor species infection prevented liver transplant, and the patient passed away. In the present case, it was decided to limit the resection to the skin and subcutaneous tissue based on a frozen section and the viability of the biopsied tissue. with consistently rising numbers of immunocompromised patients, awareness and familiarity with mucormycosis in the extremities is important. Knowing that a minimal traumatic event may precede the infection could assist in prevention and early diagnosis. Guidelines for pathological and clinical diagnosis and treatment need to be further clarified.

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An unusual infection after renal transplantation

Cited by 8 publications

References 8 publications

Primary cutaneous mucormycosis in a lung transplant recipient: case report and concise review of the literature

Primary cutaneous mucormycosis in a lung transplant recipient: case report and concise review of the literature

Zygomycosis in Solid Organ Transplant Recipients in a Tertiary Transplant Center and Review of the Literature

Mucormycosis Infection Following Intravenous Access in the Forearm

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