An Unusual Gross Appearance of Vulval Tuberculosis Masquerading as Tumor

Arakeri, Surekha U; Sinkar, Prachi

doi:10.1155/2014/815401

Cited by 8 publications

(14 citation statements)

References 3 publications

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“…When symptoms are evident, it can present with thickening and darkening of the vulvar skin and can also be associated with swelling, pruritic rash, and narrowing of the introitus . Ulceration, necrotic lesions, sinus tracts, and lymphedema have also been reported . In rare cases, it may be mistaken for a tumor .…”

Section: Mycobacterium Tuberculosismentioning

confidence: 99%

“…31 Ulceration, necrotic lesions, sinus tracts, and lymphedema have also been reported. [36][37][38] In rare cases, it may be mistaken for a tumor. 38 Inguinal lymphadenopathy may accompany vulvar changes.…”

Section: Mycobacterium Tuberculosismentioning

confidence: 99%

“…[36][37][38] In rare cases, it may be mistaken for a tumor. 38 Inguinal lymphadenopathy may accompany vulvar changes. 37 The upper genital tract often becomes involved, 38 which may lead to pelvic inflammatory disease and even infertility.…”

Section: Mycobacterium Tuberculosismentioning

confidence: 99%

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Vulvar infections: beyond sexually transmitted infections

et al. 2017

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The vulva is an under-studied area of the female genitourinary tract which is prone to maceration, overgrowth of organisms, and atypical presentations of common dermatologic conditions. In current practice, dermatologists must recognize and manage vulvar infections and infestations beyond the more commonly recognized sexually transmitted infections. Herein, this article reviews the literature on a selection of under-recognized viral, bacterial, fungal, and parasitic vulvar infections and infestations.

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Section: Mycobacterium Tuberculosismentioning

confidence: 99%

Section: Mycobacterium Tuberculosismentioning

confidence: 99%

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Vulvar infections: beyond sexually transmitted infections

et al. 2017

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“…[2][3][4] Incidence is higher in young women of reproductive age, and is often asymptomatic. 5,6 The main manifestations, such as infertility, pelvic pain or abnormal uterine hemorrhage with fallopian tube or endometrial involvement, arise as a result of the infection reaching the upper genital tract, with atypical presentation in the vulva and vagina. 6,7 Palavras-chave ► ginecologia ► doenças da vulva ► tuberculose…”

Section: Introductionmentioning

confidence: 99%

Vulvar Tuberculosis—A Rare Manifestation of the Disease

Bragança¹,

Gonçalves

Guerreiro³

et al. 2019

Rev Bras Ginecol Obstet

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“…Female genital tract (FGT) TB, first described in 1744, accounts for 0.2% to 2% of gynecological diseases. It is usually asymptomatic and therefore often under-diagnosed and overlooked [5]. The fallopian tubes and endometrium are most commonly involved.…”

Section: Introductionmentioning

confidence: 99%

Vulval Tuberculosis: The Histomorphological Spectrum in Patients with HIV Co-Infection and AIDS

Gb¹,

Ramdial²,

Nargan³

et al. 2017

J AIDS Clin Res

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Objective: Vulval tuberculosis (TB) is reported rarely. The histomorphological spectrum and diagnostic mimicry thereof in patients with concomitant HIV infection/ AIDS is unreported to date. This study aimed to appraise the histopathologic spectrum of vulval TB in HIV co-infected patients and to identify histopathological diagnostic challenges, mimicry and pitfalls.Methods: Ten year retrospective study that reappraised the histomorphological features of vulval TB in HIV-infected patients. Results:The clinical descriptions of the biopsied lesions from 19 patients that form the study cohort encompassed nodules (9), ulcers (5), hypertrophy/edema (3) and abscesses (2). The main microscopic features included necrotizing and non-necrotizing granulomatous inflammation, ulceration with a zoned inflammatory response and chronic suppurative inflammation. The necrotizing component had the typical morphology of caseative necrosis or of suppuration/karyorrhexis or an admixture of both necrosis types. Vasculitis, of varied histomorphology, was present in 15 biopsies. Infective special stains were pivotal diagnostic tools. The presence of mycobacteria on Ziehl Neelsen stains (ZNs) and absence of nonmycobacterial infective agents on additional infective stains, underpinned TB diagnosis, especially in biopsies that lacked prototypical granulomatous inflammation or of infective mimickers that manifest with a granulomatous phenotype. ZNs also confirmed mycobacteria in vasculitic foci. The absence of mycobacteria on ZNs facilitated the diagnosis of tuberculids. Conclusion:Lesions with a common clinical appearance had heterogeneous histomorphological features, while lesions with common histopathological features demonstrated divergent clinical morphology. Infective, especially Ziehl Neelsen, stains are pivotal in the histopathological work-up of infective/inflammatory vulval biopsies. It is possible that the rarely reported anergic mononuclear or abscessing features, pseudotumoral spindle cell reactions, ulcers with a zoned inflammatory response and the presence of vasculitis of varied type, are clues to the HIV-TB tissue partnership. Increased clinicopathological investigation of and reporting on vulval TB in the HIV/AIDS afflicted population is pivotal to ascertain this.

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An Unusual Gross Appearance of Vulval Tuberculosis Masquerading as Tumor

Cited by 8 publications

References 3 publications

Vulvar infections: beyond sexually transmitted infections

Vulvar infections: beyond sexually transmitted infections

Vulvar Tuberculosis—A Rare Manifestation of the Disease

Vulval Tuberculosis: The Histomorphological Spectrum in Patients with HIV Co-Infection and AIDS

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