An Unusual Cluster of Cases of Castleman's Disease during Highly Active Antiretroviral Therapy for AIDS

Highly active antiretroviral therapy alone may be an effective treatment for HIV-associated multi-centric Castleman's disease

“…They presented with persisting constitutional symptoms with generalized lymphadenopathy and hepatosplenomegaly, resembling an immune reconstitution phenomena, an observation previously suggested by Zeitz. 13 However, we demonstrated that continuation of HAART was associated with clinical improvement of MCD in our patients who remain disease free 23-38 months later, suggesting that the initial deterioration seen following HAART may be transient and not imply treatment failure. The remaining patient was antiretroviral naïve at MCD diagnosis, with CD4 count of 250 cells/mm 3 and no organ failure.…”

“…Median duration of HIV infection prior to MCD was two years (range [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. In all patients, nodes showed a mixture of reactive lymphoid follicles and follicles with irregular, regressed germinal centers.…”

Anemia hemolítica autoinmune en paciente infectado por virus de inmunodeficiencia humana y enfermedad de Castleman

“…También se han comunicado casos de rápida progresión y evolución fatal de enfermedad de Castleman relacionados con el inicio de terapia antiretroviral de alta efectividad, por lo que se recomienda tener presente esta asociación durante el uso de antiretrovirales 14 .…”

Pulmonary manifestations of human herpesvirus-8 during HIV infection

“…However, the effect of cART has never been demonstrated in MCD. Moreover, numerous cases of MCD appearing soon after the initiation of cART have been reported [86]. Nevertheless, beginning cART seems necessary because active HIV replication increases immunodeficiency and particularly the risk of lymphoma.…”