An Unusual Case of Subcutaneous Fat Necrosis in a Newly Born Infant

Craig, W. S.

doi:10.1136/adc.40.211.326

Archives of Disease in Childhood

1965

DOI: 10.1136/adc.40.211.326

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An Unusual Case of Subcutaneous Fat Necrosis in a Newly Born Infant

W. S. Craig¹

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1969

1987

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Cited by 3 publications

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Studies on subcutaneous fat necrosis of the newborn

Pasyk¹

1978

Virchows Arch. A Path. Anat. and Histol.

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Biopsy specimens from the skin and subcutaneous fat tissue of four cases with neonatal subcutaneous fat necrosis were made and investigated by light and electron microscopy at 2, 4, and 6 weeks, and 5 months (Case 2) from the onset of the disease. Three stages of ultrastructural change of fat cells were observed. The evolution of crystal formation in the fat cells was seen and phagocytosis of crystals and fat droplets by macrophages and foreign-body giant cells was also noted. In the light microscope accumulation of calcium concretions in the spaces between and inside the fat cells was found. In the electron microscope we detected foci of highly electron-dense granules, which were similar in distribution and structure to calcium salts stained with the von Kossa method. Changes in small and medium size blood vessels were observed.

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Studies on subcutaneous fat necrosis of the newborn

Pasyk¹

1978

Virchows Arch. A Path. Anat. and Histol.

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Vitamin D deficiency rickets after vitamin D hypersensitivity with subcutaneous fat necrosis in the newborn period

Wehinger

1969

Z. Kinderheilk.

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A case report is given on a child with severe subcutaneous fat necrosis following perinatal asphyxia. After the administration of 2 x 2.5 mgm of vitamin D at the age of two weeks the child developed hypercalcemia and severe soft tissue calcifications. In spite of a low calcium diet the hypercalcemia persisted while small doses of vitamin D were administered (240 I.U. per day); it disappeared promptly as soon as vitamin D was completely withdrawn. At the age of 22 months the child showed signs of vitamin D deficiency, which disappeared with a daily dose of 1000 I.U. of vitamin D. This time no signs of toxicity were observed. Possibly newborns with subcutaneous fat necrosis have transient hypersensitivity to vitamin D; the pathogenesis of the phenomenon is unknown.Schliisselw6rter: Adiponekrosis subcutanea --Vitamin D-t~berempfindlichkeit --l%achitis.Die Adiponekrosis subcutanea des Neugeborenen ffihrt zwar nicht selten zu Verkalkungen subcutanen Fettgewebes, ist aber prim/it nicht mit ~nderungen des Serum-Calciumspiegels verknfipft. In neuerer Zeit mehren sich jedoch Beobachtungen, nach denen bei diesen Kindern eine gesteigerte Vitamin D-Empfindlichkeit besteht, so daf3 Vitamin D-Dosen wie sie bei der Vitamin D-Prophylaxe der Rachitis verabfolgt werden, zu schweren Hypercalci/~mie-Syndromen ffihren kSnnen. Im folgenden wird fiber einen derartigen Fall berichtet, der dadurch yon besonderem Interesse ist, dal3 sich im AnschluB an die Vitamin D-1Jberempfindlichkeit im frfihen S/~uglingsalter eine Vitamin D-Mangel-Rachitis am Ende des 2. Lebensjahres entwickelte 1.

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Subcutaneous Fat Necrosis of the Newborn With Emphasis on Ultrastructural Studies

Balázs

1987

Int J Dermatology

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The morphologic examination of neonatal subcutaneous fat necrosis is reported. Subcutaneous nodules after prolonged labor and asphyxia appeared in the skin of the back and neck. Biopsy was performed at 16 days. The infants' general state did not change and the nodules spontaneously regressed. Light microscopically focal necroses of the subcutaneous adipose tissue were present, with granulation tissue. Electron microscopy revealed complex material replacing the necrotic fat cells. Two types of crystals could be observed: short, rectangular ones irregularly arranged and long, needle-shaped ones, parallel or radial in arrangement. The dissolved lipid crystals were surrounded by membranes that probably arose from the necrotic fat cells. The crystals passed the cytoplasm membrane of the macrophages. Giant cells arose from macrophages, partly by fusion of the cells and partly by amitosis.

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An Unusual Case of Subcutaneous Fat Necrosis in a Newly Born Infant

Cited by 3 publications

References 3 publications

Studies on subcutaneous fat necrosis of the newborn

Studies on subcutaneous fat necrosis of the newborn

Vitamin D deficiency rickets after vitamin D hypersensitivity with subcutaneous fat necrosis in the newborn period

Subcutaneous Fat Necrosis of the Newborn With Emphasis on Ultrastructural Studies

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