An Unusual Case of Neonatal Brain Abscess Following Klebsiella pneumoniae Septicemia

Basu, Sulagna; Mukherjee, Kanchan Kumar; Poddar, Banani; Goraya, J.S.; Chawla, Kiran; Parmar, Veena R.

doi:10.1007/s15010-001-1082-1

Cited by 18 publications

(10 citation statements)

References 6 publications

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“…1 Gram-negative organisms with a propensity to cause necrotizing vasculitis like Citrobacter species, Proteus species, Pseudomonas species, and Serratia species are more commonly associated with brain abscesses with only 2 case reports of Klebsiella pneumoniae brain abscess published until now. 3,4 This is despite the fact that Klebsiella pneumoniae is the most common organism causing neonatal sepsis in developing countries. 5,6 In one of the largest series of 30 neonates with brain abscess in a tertiary center, no case was attributed to Klebsiella species.…”

Section: Discussionmentioning

confidence: 99%

Klebsiella pneumoniae Brain Abscess in Neonates: A Report of 2 Cases

et al. 2009

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Brain abscesses are uncommon in neonates. Klebsiella pneumoniae is a very uncommon microbial agent to cause brain abscess. We report 2 infants with Klebsiella pneumoniae sepsis who developed brain abscesses. One infant was a premature neonate who required mechanical ventilation for respiratory distress syndrome and subsequently developed nosocomial sepsis and brain abscess without evidence of preceding meningitis. Another infant was a full-term neonate without risk factors for sepsis who developed seizures on the sixth postnatal day and was found to have meningitis and brain abscess. Both infants had Klebsiella pneumoniae septicemia with multiple relatively large brain abscesses that responded poorly to antimicrobial agents. These infants were managed with transfontanel drainage and prolonged courses of antimicrobial agents. Key message of this report is that Klebsiella pneumoniae brain abscess may occur in the absence of meningitis and even in the absence of any identifiable risk factors.

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Section: Discussionmentioning

confidence: 99%

Klebsiella pneumoniae Brain Abscess in Neonates: A Report of 2 Cases

et al. 2009

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“…Eradication of the pathogen often is delayed, and serious complications can occur [23,119,348,632]. Meningitis caused by gram-negative enteric bacilli can pose special management problems.…”

Section: Treatment Of Neonatal Meningitismentioning

confidence: 99%

Bacterial Sepsis and Meningitis

Nizet¹,

Klein²

2011

Infectious Diseases of the Fetus and Newborn

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“…In one series, 10 of 30 neonates with brain abscesses, maternal urinary tract infection (UTI) was observed in eight cases and it was concluded that in many more the documentation of maternal illness was missing. In the report by Basu et al, [7], the mother had possible UTI during pregnancy which was overlooked. In the neonates described by Pant et al, [8], maternal UTI and prolonged rupture of membranes were the risk factors present.…”

Section: Discussionmentioning

confidence: 99%