An Unusual Case of Metastatic Non-Small Cell Lung Cancer Misidentified as Anaplastic Thyroid Cancer

Ko, Hye Mi; Kim, Je-Ryong

doi:10.11106/ijt.2020.13.2.170

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…Surgery is indicated in patients with isolated thyroid lesions with no evidence of metastasis in other sites and for relieving compressive symptoms in patients with disseminated disease 17 . The prognosis remains poor in most cases, and the surgery does not contribute to prolonging the life of patients 10 , 18 . Systemic treatment with chemotherapy or targeted therapy is used in the case of a poly metastatic tumour.…”

Section: Discussionmentioning

confidence: 99%

Metastatic squamous cell carcinoma of the lung to the thyroid gland presented as nodular goiter: a rare case report

Al-janabi

Zainab

Wannous

et al. 2023

Annals of Medicine &Amp; Surgery

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Introduction and importance: Metastasis of squamous cell lung carcinoma to the thyroid gland is an extremely rare event. It frequently metastasizes to lymph nodes, liver, adrenal glands, bone, brain, and pleura. Among the lung carcinomas metastasizing to the thyroid, adenocarcinomas are the most common followed by squamous cell carcinomas (SCCs). Case presentation: A 58-year-old male patient presented with bilateral neck swelling. Fine needle aspiration is performed and was undetermined. Ultrasonography of the neck demonstrated multiple hypoechoic nodules with thyroid enlargement. The patient was diagnosed with nodular goitre and he underwent a total thyroidectomy. Microscopically, the Hematoxylin and eosin-stained sections revealed thyroid follicles with sheets composed of polygonal cells with pleomorphic nuclei, prominent nucleoli, and a moderate amount of eosinophilic cytoplasm. Keratin pearls were present. Based on histopathological and clinical findings, the final diagnosis was metastatic SCC to the thyroid gland. Clinical discussion: Clinically, patients with thyroid metastasis presented with nonspecific symptoms such as thyroid nodule or goitre, cervical discomfort, dyspnoea, dysphagia, or dysphonia. Chemotherapy is used in the case of a poly metastatic tumour and radiotherapy as a palliative treatment whereas radioiodine treatment is not indicated for thyroid metastases. Conclusion: Diagnosis of SCC in the thyroid gland as a primary or metastatic neoplasm is a significant challenge. In the absence of specific clinical or radiological signs, pathological studies remain the gold standard for diagnosis.

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Section: Discussionmentioning

confidence: 99%

Metastatic squamous cell carcinoma of the lung to the thyroid gland presented as nodular goiter: a rare case report

Al-janabi

Zainab

Wannous

et al. 2023

Annals of Medicine &Amp; Surgery

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“…Only a few cases of primary lung adenocarcinoma were reported. Research of English language reports using the keywords “lung adenocarcinoma and thyroid metastasis” revealed only 13 cases of thyroid metastasis from pulmonary adenocarcinoma ( Table 1 ) [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] .…”

Section: Discussionmentioning

confidence: 99%

“…Systemic treatment with chemotherapy or targeted therapy is used in the case of polymetastatic cancer. Radiotherapy is used as a palliative treatment for symptoms due to thyroid metastases [7] Radioiodine treatment is not indicated for thyroid metastases [12] .…”

Section: Discussionmentioning

confidence: 99%

Thyroid metastasis revealing a lung adenocarcinoma: A case report and review of the literature

Elouarith

Benbella

Arsalan

et al. 2022

International Journal of Surgery Case Reports

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Clinicopathological and Molecular Features of Secondary Cancer (Metastasis) to the Thyroid and Advances in Management

Nguyen

Lam

2022

IJMS

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Secondary tumours to the thyroid gland are uncommon and often incidentally discovered on imaging. Symptomatic patients often present with a neck mass. Collision tumours of secondary tumours and primary thyroid neoplasms do occur. Ultrasound-guided fine-needle aspiration, core-needle biopsy, and surgical resection with histological and immunohistochemical analysis are employed to confirm diagnosis as well as for applying molecular studies to identify candidates for targeted therapy. Biopsy at the metastatic site can identify mutations (such as EGFR, K-Ras, VHL) and translocations (such as EML4-ALK fusion) important in planning target therapies. Patients with advanced-stage primary cancers, widespread dissemination, or unknown primary origin often have a poor prognosis. Those with isolated metastasis to the thyroid have better survival outcomes and are more likely to undergo thyroid resection. Systemic therapies, such as chemotherapy and hormonal therapy, are often used as adjuvant treatment post-operatively or in patients with disseminated disease. New targeted therapies, such as tyrosine kinase inhibitors and immune checkpoint inhibitors, have shown success in reported cases. A tailored treatment plan based on primary tumour features, overall cancer burden, and co-morbidities is imperative. To conclude, secondary cancer to the thyroid is uncommon, and awareness of the updates on diagnosis and management is needed.

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An Unusual Case of Metastatic Non-Small Cell Lung Cancer Misidentified as Anaplastic Thyroid Cancer

Cited by 3 publications

References 16 publications

Metastatic squamous cell carcinoma of the lung to the thyroid gland presented as nodular goiter: a rare case report

Metastatic squamous cell carcinoma of the lung to the thyroid gland presented as nodular goiter: a rare case report

Thyroid metastasis revealing a lung adenocarcinoma: A case report and review of the literature

Clinicopathological and Molecular Features of Secondary Cancer (Metastasis) to the Thyroid and Advances in Management

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