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Background: Pilomatrixoma is a benign skin tumor arising from the hair matrix cells. It is typically found in the head and neck region. However, few cases of pilomatrixoma that mimic a pyogenic granuloma have been reported. Clinicians should be aware of it because it may recurrence and transform into a malignant tumor. Case Presentation: We report a rare case of a 9-year-old boy who presented with an asymptomatic mass on the left cheek for 2 months. Clinically, it was diagnosed as a pyogenic granuloma. An excisional biopsy was performed and sent to the pathology department for histopathological study. Histological examination showed that it was a pilomatrixoma. The patient was discharged on the same day, without any complications. Conclusion: Pilomatrixoma is often misdiagnosed clinically; therefore, the definitive diagnosis of skin tumors should be made after a histologic examination of the excisional mass. Surgical resection with wide margins was the optimal treatment for pilomatrixoma because local recurrence may occur.

Melanoma is a malignancy that develops from pigment-producing cells known as melanocytes. Although it is considered one of the most fatal tumors in the world, its early diagnosis is associated with a better prognosis and overall survival. A 49-year-old man was admitted to the dermatology department with a 15 cm lesion on the left arm. It was growing on a congenital nevus to reach an enormous size. Surgical excision was not possible and the treatment was controversial as the patient showed unpredicted resistance to immunotherapy. Further evaluations revealed false-negative BRAF mutation, which completely changed the course of treatment. Cutaneous melanoma is a rare malignancy, accounting only for 1% of skin cancer cases, and having it arising on a pre-existing congenital nevus is even much rarer. Although there is no decisive definition of giant melanoma, some authors define it as a lesion of more than 10 cm in diameter. Through the literature, only a few cases of giant melanoma on the arm have been reported. Through our paper, we are revealing the importance of early diagnosis and treatment of melanoma and confirming the significant role of regular follow-up for patients with a congenital melanocytic nevus. Moreover, we are showing the importance of having alternative methods for detecting BRAF mutations to avoid false-negative results and have better outcomes.

Marburg virus disease (MVD), formerly known as Marburg hemorrhagic fever, is a very serious infection with a high mortality rate caused by the Marburg virus (MARV) [1] . It was first identified in Europe in 1967, and it is in the same family as Ebola [2] . Recently, the highly infectious MARV has been reported in the West African country of Ghana [3] . MARV is transmitted to humans by African fruit bats due to their work in mines and caves [3] . In addition, this virus can also be transmitted from human to human through exposure to body fluids, skin lesions, and unprotected sex [1,3] . Fortunately, MVD is not an airborne disease, and transmission does not occur during the incubation period [4] . Clinically, the MARV infection may present as a high fever, severe headache, malaise, hemorrhage, and a non-itchy rash on the chest and back [3,5] . Death occurs due to severe blood loss and multiorgan dysfunction. Diagnosis can be done by several tests, such as isolation in viral culture, polymerase chain reaction serology, and immunohistochemistry [3,5] . The main treatment for patients with MARV infection is supportive therapy, such as dehydration and supplemental oxygen [3,5] . In contrast, there is no antiviral drug or vaccine approved against MARV [1,5] . In conclusion, noncompliance with appropriate protective measures, when handling animals and the lack of a specific treatment or vaccine available, led to the MVD outbreak. However, educational public health messages are essential to stopping the spread of MVD. We recommend following the health care guidelines, such as thoroughly cooking animal products and using appropriate protective clothing in contact with animals; moreover, animal products should be cooked before consumption. Regular hand washing is required after visiting patients. All these preventative methods can help prevent an outbreak and avoid a pandemic, like the coronavirus disease 2019 pandemic, which led to the isolation of the world for nearly 2 years and claimed more than a million lives. Ethical approvalNot applicable. Sources of fundingThere is no funding source.

Ectopic adrenal tissue (EAT) is an extremely unusual finding. The most common site is the genitourinary tract and pelvis, and more frequently in males than females. In our report, we discuss an ectopic adrenal cortical tissue detected in the descending mesocolon in an elderly female. To the best of our knowledge, this case is the first report in the English literature.