An Unusual Case of Klebsiella pneumoniae Endocarditis

Hassan, Syed Adeel; Akhtar, Aisha; Falah, Noor Ul; Khan, Manoranjan

doi:10.7759/cureus.6999

Cited by 7 publications

(10 citation statements)

References 4 publications

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“…Case reports of patients with Klebsiella pneumoninae endocarditis described similar presentations to the patient presented above [18] , [19] . However, Klebsiella pneumoninae endocarditis is rare; it accounts for less than 5 % of all cases of endocarditis [18] , [19] .…”

Section: Discussionsupporting

confidence: 52%

A complex presentation of an uncommon disease: Gas-forming pyogenic liver abscess complicated by septic pulmonary emboli and muscle abscesses, a case report and review of the literature

Alzibdeh

Alamami

Adam

et al. 2023

IDCases

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Section: Discussionsupporting

confidence: 52%

A complex presentation of an uncommon disease: Gas-forming pyogenic liver abscess complicated by septic pulmonary emboli and muscle abscesses, a case report and review of the literature

Alzibdeh

Alamami

Adam

et al. 2023

IDCases

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“…Presentation can be associated with septic emboli to the lungs as in the presented case 6 . Liver abscess and urinary tract infection are the most common source when bacteremia is present 36 . Mortality rates vary depending on the pathogen, virulence factors, complications and the valve involved, reaching up to 49% in one article 6 , 37 .…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of infective endocarditis due to pandrug-resistant Klebsiella pneumoniae with ceftazidime-avibactam and aztreonam

Alghoribi

Alqurashi

Okdah

et al. 2021

Sci Rep

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Pandrug-resistant (PDR) K. pneumoniae refractory to conventional treatment has been reported worldwide, causing a huge burden on the healthcare system, patient safety and the economy. K. pneumoniae is a prominent opportunistic pathogen causing hospital-acquired and community-acquired infections, but is rarely associated with infective endocarditis. Currently, there are sparse data guiding the optimal regimen when commonly used antibiotics fail, notably for the treatment of endocarditis infections. Here we report our experience in treating a 40-year-old female with PDR K. pneumoniae infection of cardiovascular implantable electronic device (CIED) and right-sided infective endocarditis. Initial susceptibility testing of the incriminated pathogen showed an apparent susceptibility to colistin but the prolonged course of colistin, gentamicin and meropenem did not resolve the infection. However, the synergistic combinations of aztreonam with ceftazidime-avibactam was able to overcome resistance and clear the infection rapidly. Genome sequencing showed that the PDR K. pneumoniae isolate belongs to the international high-risk clone ST14. The isolate harbored genes encoding NDM-1, OXA-48, CTX-M-14b, SHV-28 and OXA-1, explaining resistance to all β-lactams, including carbapenems. It carried the armA gene conferring resistance to all clinically important aminoglycosides and had alterations in GyrA, ParC and MgrB, explaining resistance to ciprofloxacin and colistin.

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“…The study area consists of Lahore which is geographically situated between 31°15'-31°45'N latitude and 74°01'-74°39'E longitude. The total area of the city is 1772 km 2 having hot semiarid climate with mean annual rainfall of 675 mm, varying from 300-1200 mm and average annual temperature of approximately 24ºC [9]. The bed rock is constituted of the unconsolidated alluvial complex of contemporaneous filling of subsiding trough-mainly composed of sodium and calcium bicarbonates.…”

Section: Study Areamentioning

confidence: 99%

“…The land cover of the city has changed as more than 1200 hectares of agricultural and forest land is acquired for urban use each year and impervious surface has increased by 11.9% reducing the natural recharge (Ahmed et al, 2001). Groundwater is the only source of fresh water supply and approximately 3500 Acre Feet (AF) of water is extracted per day from 1800 public and private tube wells resulting into the water table level decline [9,29].…”

Section: Study Areamentioning

confidence: 99%

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Assessment of Filtration System Efficiency of Artificial Groundwater Recharge wells in Lahore

Hameed¹,

Arooj²,

Luqman³

et al. 2022

Pol. J. Environ. Stud.

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Groundwater recharge is an important process that naturally maintains both water quantity and quality in a given aquifer. However, aquifers of mega cities are shrinking owing to poor urban-water planning and management especially due to lack of surface rainwater recharge systems. Therefore, this study was designed to evaluate the efficiency of filtration system of artificial groundwater recharge wells which is the most viable surface rainwater harvesting (RWH) techniques in urban areas. Henceforth, a total of two artificial surface recharge wells were selected for water sampling from five different points namely rain-gauge, runoff, silt trapper, roughing block and invert well during Monsoon Season in Lahore and characterized in terms of Physico-chemical and microbial parameters. These recharge wells were monitored to evaluate real-time pollutants filtration potential of storm water after every episode of rain. The results revealed that, overall recharged water quality after filtration was quite satisfactory because filtrate media drastically reduced the turbidity level in all examined samples. Other parameters were also within permissible limits according to drinking water quality standards. Overall, 92.5%, 62.7%, 50.06%, 21.42%, 50%, 16.6%, 90% and 99% reduction in turbidity, conductivity, TDS, Na, K, Ca, NO 3 and coliform respectively was achieved using installed filter media which was significant statistically (p<0.05). Henceforth, artificial groundwater recharge well is a sustainable, cost-effective tool that reduces burden on urban aquifer, alleviate energy consumption and manage urban rainwater runoff quality without polluting the aquifer.

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An Unusual Case of Klebsiella pneumoniae Endocarditis

Cited by 7 publications

References 4 publications

A complex presentation of an uncommon disease: Gas-forming pyogenic liver abscess complicated by septic pulmonary emboli and muscle abscesses, a case report and review of the literature

A complex presentation of an uncommon disease: Gas-forming pyogenic liver abscess complicated by septic pulmonary emboli and muscle abscesses, a case report and review of the literature

Successful treatment of infective endocarditis due to pandrug-resistant Klebsiella pneumoniae with ceftazidime-avibactam and aztreonam

Assessment of Filtration System Efficiency of Artificial Groundwater Recharge wells in Lahore

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