An untargeted LC-MS metabolomics approach to the metabolic profiles of bottom cultured scallops (Mizuhopecten yessoensis) subjected to mechanical shock in early post-harvest handling

Tian, Yuanyong; Xu, Tanye; Li, Yaxuan; Liu, Yang; Liu, Junrong

doi:10.1016/j.aquaculture.2020.736061

Cited by 13 publications

(9 citation statements)

References 28 publications

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“…Bioactive peptides are specific and have positive effects on health [43] . Anserine, carnosine, and glutathione are important small peptides in animal tissues, all of which have antioxidant properties that reduce oxidative stress and prevent the deterioration associated with meat oxidation during postmortem aging [44] , [45] . In the present study, we found that ultrasound-assisted thawing increased the content of anserine (UT1), glutathione (UT1) and carnosine (UT7) in lamb, which may ensure the stability of protein and lipid oxidation in lamb.…”

Section: Resultsmentioning

confidence: 99%

Effects of ultrasound-assisted thawing on lamb meat quality and oxidative stability during refrigerated storage using non-targeted metabolomics

Zang

Qiao

et al. 2022

Ultrasonics Sonochemistry

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Section: Resultsmentioning

confidence: 99%

Effects of ultrasound-assisted thawing on lamb meat quality and oxidative stability during refrigerated storage using non-targeted metabolomics

Zang

Qiao

et al. 2022

Ultrasonics Sonochemistry

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“…The ovaries of F4 females from control and BPA lineage were pooled respectively and used to extract ovarian metabolites. According to a published protocol, 73 ovary samples (20 mg) were homogenized in an ultrasonically extracted solution consisting of methanol/acetonitrile/water (2:2:1, v/v), vortex mixed, and ultrasonically extracted twice at a low temperature for 30 min. After incubation at −20 °C for 1 h, the mixture was centrifuged at 13,000 rpm at 4 °C for 15 min.…”

Section: Methodsmentioning

confidence: 99%

The PCOS–NAFLD Multidisease Phenotype Occurred in Medaka Fish Four Generations after the Removal of Bisphenol A Exposure

Chakraborty

Anand

Coe

et al. 2023

Environ. Sci. Technol.

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As a heterogeneous reproductive disorder, polycystic ovary syndrome (PCOS) can be caused by genetic, diet, and environmental factors. Bisphenol A (BPA) can induce PCOS and nonalcoholic fatty liver disease (NAFLD) due to direct exposure; however, whether these phenotypes persist in future unexposed generations is not currently understood. In a previous study, we observed that transgenerational NAFLD persisted in female medaka for five generations (F4) after exposure to an environmentally relevant concentration (10 μg/L) of BPA. Here, we demonstrate PCOS in the same F4 generation female medaka that developed NAFLD. The ovaries contained immature follicles, restricted follicular progression, and degenerated follicles, which are characteristics of PCOS. Untargeted metabolomic analysis revealed 17 biomarkers in the ovary of BPA lineage fish, whereas transcriptomic analysis revealed 292 genes abnormally expressed, which were similar to human patients with PCOS. Metabolomic–transcriptomic joint pathway analysis revealed activation of the cancerous pathway, arginine–proline metabolism, insulin signaling, AMPK, and HOTAIR regulatory pathways, as well as upstream regulators esr1 and tgf signaling in the ovary. The present results suggest that ancestral BPA exposure can lead to PCOS phenotypes in the subsequent unexposed generations and warrant further investigations into potential health risks in future generations caused by initial exposure to EDCs.

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“…Samples were prepared as described by Tian et al . (2021) with modifications. Samples were lyophilised in a vacuum freeze dryer and ground into powder.…”

Section: Methodsmentioning

confidence: 99%

Metabolites of the Soy Sauce Koji Making with Aspergillus niger and Aspergillus oryzae

Liu

et al. 2021

Int J of Food Sci Tech

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Koji making comprises multi-microbial interactions and is an important part of soy sauce production. The aim of this study was to determine interactions and investigate metabolites in koji by ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q/ TOF-MS). Differential metabolites between groups of single strain (Aspergillus oryzae) and mixed strains (Aspergillus niger and A. oryzae) koji making were screened and identified using an untargeted metabolomics approach to evaluate microbial interaction. A. oryzae was the dominant strain in koji mixed fermentation. Growth of both fungal species occurred rapidly during the initial 24 h of fermentation and then stabilised. Inoculation of A. niger led to changes in the contents of dipeptides, flavonoids, unsaturated fatty acids, carotenoids, phenols and indoles in koji. These differences could be attributed to glycerophospholipid and glycerolipid m4etabolism, as well as to pantothenate and CoA biosynthesis of A. niger.

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An untargeted LC-MS metabolomics approach to the metabolic profiles of bottom cultured scallops (Mizuhopecten yessoensis) subjected to mechanical shock in early post-harvest handling

Cited by 13 publications

References 28 publications

Effects of ultrasound-assisted thawing on lamb meat quality and oxidative stability during refrigerated storage using non-targeted metabolomics

Effects of ultrasound-assisted thawing on lamb meat quality and oxidative stability during refrigerated storage using non-targeted metabolomics

The PCOS–NAFLD Multidisease Phenotype Occurred in Medaka Fish Four Generations after the Removal of Bisphenol A Exposure

Metabolites of the Soy Sauce Koji Making with Aspergillus niger and Aspergillus oryzae

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