An unidentified inhibitor of lipid peroxidation in intestinal mucosa

Balasubramanian, K.A.; Manohar, Madhura; Mathan, V. I.

doi:10.1016/0005-2760(88)90094-x

Cited by 81 publications

(49 citation statements)

References 14 publications

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“…Quantitative estimation of GSH was done by the method where reduced GSH was reacted with 5-5' dithiobis-2-nitrobenzoic acid (DTNB) and absorbance was measured at 412 nm [14] . The activity of GPx [15] and TBARS [16] was estimated as prescribed by the previous studies. , respectively against concentration gradient at the cost of ATP molecule liberating inorganic phosphate (Pi).…”

Section: Experimental Designmentioning

confidence: 99%

Hepatoprotective Potential of Green Tea Extract against Experimental Hepatotoxicity in Rats

Reddy¹

2017

ijps

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Anudeep, et al.: Green Tea (Camellia sinensis) in HepatotoxicityAn experimental study was conducted to evaluate the hepatoprotective effect of aqueous extract of Camellia sinensis or green tea extract and N-acetyl-L-cysteine in acetaminophen-induced hepatotoxicity in rats. Male Wistar rats (n=24) of 3 mon age were equally divided into 4 groups. Group 1 served as normal control. Hepatotoxicity was induced in the remaining three groups with oral administration of 500 mg/kg of acetaminophen from day 1 to day 3. Groups 2, 3 and 4 were subsequently administered orally with distilled water, 300 mg/kg of N-acetyl-L-cysteine and 100 mg/kg green tea extract, respectively for 11 d. Mean body weights and biomarkers of hepatotoxicity were estimated on days 0, 4 (confirmation of toxicity) 15 (at the end of treatment). Hematological parameters were evaluated on 4 and 15 d. Antioxidant profile and ATPase enzymes were assessed at the end of the experiment. Livers were subjected to histopathology and transmission electron microscopy after the sacrifice on day 15. Antioxidant profile, ATPase, haematological and serobiochemical parameters were significantly altered and histopathological changes were noticed in liver of toxic control group. These changes were reversed in groups 3 and 4 that were administered with N-acetyl-L-cysteine and green tea extract, respectively. The results of the present investigation enunciated that green tea extract has potent hepatoprotective activity, though N-acetyl-L-cysteine was found superior in restoring the pathological alterations in acetaminophen-induced hepatotoxicity in Wistar rats.

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Section: Experimental Designmentioning

confidence: 99%

Hepatoprotective Potential of Green Tea Extract against Experimental Hepatotoxicity in Rats

Reddy¹

2017

ijps

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“…Lipid peroxidation was measured by the thiobarbituric acid colour reaction for malondialdehyde (MDA) [16]. Protein carbonyl content was measured spectrophotometrically using 2,4-dinitro-phenyl-hydrazine [17].…”

Section: Measurements In Plasmamentioning

confidence: 99%

Maternal dietary vitamin restriction increases body fat content but not insulin resistance in WNIN rat offspring up to 6 months of age

et al. 2004

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Aims/hypothesis. Epidemiological evidence suggests that some adult diseases like insulin resistance syndrome and diseases associated with it originate in fetal life. The role of maternal macronutrient malnutrition but not of micronutrients in the fetal origin of adult disease is well studied. We hypothesise that chronic maternal vitamin restriction predisposes the offspring to insulin resistance syndrome. Methods. Female weanling Wistar/NIN rats received a control diet (n=6) or a 50% vitamin-restricted diet (n=14) for 12 weeks and mated with control males. Four dams on the restricted diet were shifted to the control diet from parturition. Pups born to the remaining 10 dams on the restricted diet were weaned on to control diet or continued on the restricted diet. All groups had 8 male pups from weaning onwards.Results. Birthweights of pups were comparable among different groups. Weaning body weights were low in the restricted diet group, but on rehabilitation they caught up with control animals by post-natal day 100. None of the pups had impaired oral glucose tolerance and their insulin resistance status was comparable on days 40, 70, 100 and 180. Compared with offspring on the control diet, offspring on the restricted diet had a significantly higher percentage of body fat and higher plasma triglycerides, as well as lower lean body mass and fat-free mass. They also had increased oxidative stress. Rehabilitation from parturition or weaning prevented the changes in body fat percent, lean body mass, fat-free mass and oxidative stress. Conclusions/interpretation. Since changes in adiposity and fat metabolism are considered forerunners of insulin resistance syndrome, our observations suggest that maternal dietary vitamin restriction predisposes the offspring to insulin resistance syndrome in later life.

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“…Lipid peroxidation was measured by the thiobarbituric acid color reaction for malondialdehyde (MDA) (28). Protein carbonyl content was measured spectrophotometrically using 2,4-dinitrophenyl-hydrazine (29).…”

Section: Oxidative Stress and Antioxidant Statusmentioning

confidence: 99%

Does maternal dietary mineral restriction per se predispose the offspring to insulin resistance?

Lagishetty

Nemani

Krishna

et al. 2004

European Journal of Endocrinology

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Background: Maternal undernutrition is hypothesized to predispose the offspring to disease in adult life. The relevance of maternal macronutrient deficiency has been well studied but not that of micronutrients. Objective: To assess the effect of maternal dietary mineral restriction per se on oral glucose tolerance (OGT), insulin resistance (IR) and fat metabolism in offspring. Design: Female weanling Wistar/NIN rats received a control or a 50% mineral-restricted (MR) diet for 12 weeks, by which time MR rats had lower plasma Fe, Zn, Mg and Ca concentrations. Following mating with control males, a third of the MR dams were shifted to the control diet from parturition. Half of the pups born to the remaining MR dams were weaned onto the control diet while the other half continued on the MR diet. Results: Pregnant MR dams had a higher abortion rate, body weights of their pups at birth and weaning were lower and rehabilitation had no beneficial effect. No offspring had impaired OGT, and IR status was comparable among different groups on postnatal days 40, 70, 100 or 180. Compared with controls, total body electrical conductivity measurements indicated significantly higher body fat %, lower lean body mass and fat-free mass in MR offspring besides elevated plasma triacylglycerols. Mineral rehabilitation from parturition or weaning had little effect on these changes, which did not appear to be due to increased oxidative stress. Conclusions: Maternal MR per se resulted in an increase in body fat and in plasma triacylglycerol concentrations in the offspring. These changes had, however, no discernable effect on insulin sensitivity over the first 180 days of life.

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An unidentified inhibitor of lipid peroxidation in intestinal mucosa

Cited by 81 publications

References 14 publications

Hepatoprotective Potential of Green Tea Extract against Experimental Hepatotoxicity in Rats

Hepatoprotective Potential of Green Tea Extract against Experimental Hepatotoxicity in Rats

Maternal dietary vitamin restriction increases body fat content but not insulin resistance in WNIN rat offspring up to 6 months of age

Does maternal dietary mineral restriction per se predispose the offspring to insulin resistance?

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