Hepatoprotective Potential of Green Tea Extract against Experimental Hepatotoxicity in Rats

Abstract

Anudeep, et al.: Green Tea (Camellia sinensis) in HepatotoxicityAn experimental study was conducted to evaluate the hepatoprotective effect of aqueous extract of Camellia sinensis or green tea extract and N-acetyl-L-cysteine in acetaminophen-induced hepatotoxicity in rats. Male Wistar rats (n=24) of 3 mon age were equally divided into 4 groups. Group 1 served as normal control. Hepatotoxicity was induced in the remaining three groups with oral administration of 500 mg/kg of acetaminophen from day 1 to day 3. Groups 2, 3 and 4 were subsequently administered orally with distilled water, 300 mg/kg of N-acetyl-L-cysteine and 100 mg/kg green tea extract, respectively for 11 d. Mean body weights and biomarkers of hepatotoxicity were estimated on days 0, 4 (confirmation of toxicity) 15 (at the end of treatment). Hematological parameters were evaluated on 4 and 15 d. Antioxidant profile and ATPase enzymes were assessed at the end of the experiment. Livers were subjected to histopathology and transmission electron microscopy after the sacrifice on day 15. Antioxidant profile, ATPase, haematological and serobiochemical parameters were significantly altered and histopathological changes were noticed in liver of toxic control group. These changes were reversed in groups 3 and 4 that were administered with N-acetyl-L-cysteine and green tea extract, respectively. The results of the present investigation enunciated that green tea extract has potent hepatoprotective activity, though N-acetyl-L-cysteine was found superior in restoring the pathological alterations in acetaminophen-induced hepatotoxicity in Wistar rats.

Antioxidative, Anti-Inflammatory, Anti-Obesogenic, and Antidiabetic Properties of Tea Polyphenols—The Positive Impact of Regular Tea Consumption as an Element of Prophylaxis and Pharmacotherapy Support in Endometrial Cancer

“…Hepatotoxicity is probably caused by an enzymatic reaction (alcohol dehydrogenase, P450 cytochrome, mitochondrial enzyme), leading to cell damage and interference with biological response systems and metabolic reactions [ 221 ]. Contrary results were reported in rat studies where a green tea extract was shown to have hepatoprotective properties [ 53 , 222 , 223 ]. The antioxidative properties of tea are due primarily to its content of polyphenols, the highest, over 2000 mg in 1000 mL, in white and green tea, and approximately half that in black and red varieties [ 53 ].…”

Rats cholestasis instigated by 𝛼-Naphthylisothiocyanate and the impacts of green tea (Camellia sinensis) antioxidant

“…The destructive ascorbic acid, also called vitamin C (VC), is prominent for applying antioxidant and reducing exercises (Sorice et al, 2014). This investigation demonstrates that green tea extricates control weight actuated liver harm, in any event to a lesser degree, through its cell reinforcement and calming exercises identified with VC (Reddy et al, 2017). Furthermore, VC has been proven to hinder the harm to liver cells (Yang et al, 2018), yet not cholestasis, in rats treated with a solitary ANIT treatment, at any rate to some degree, through its cancer prevention agent and calming exercises (Ohta et al, 2006;Han et al, 2018).…”

The effects of Curcuma xanthorrhiza rhizome simplicia and Camellia sinensis green tea in a patient with chronic hepatitis B infection: a case report

“…1 Epigallocatechin-3-gallate can also suppress HBV replication and expression by inhibiting HBV promoter transcription and DNA replication, inducing incomplete viral autophagy, and inhibiting chronic pathogenesis. 13 Green tea also has antioxidant and hepatoprotective activities, 14,15 such that it can reverse oxidative stress that may occur due to HBV infection. By capturing free radicals, the balance between redox and cellular antioxidants is maintained, which results in no liver cell damage.…”