An unidentified depressor substance in certain tissue extracts

Euler, U. S. v.; Gaddum, J. H.

doi:10.1113/jphysiol.1931.sp002763

Cited by 1,486 publications

(419 citation statements)

References 7 publications

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“…Among many other topics, Sir John Gaddum was interested in neurotransmission and he made important contributions in the field of cholinergic (Chang & Gaddum, 1933;Feldberg & Gaddum, 1934) and noradrenergic transmission (Gaddum & Kwiatowski, 1939;Gaddum, Peart & Vogt, 1949; Gaddum, 1950). The work of Sir John Gaddum is also linked to the discovery of other putative neurotransmitters like Substance P and 5-hydroxytryptamine (von Euler & Gaddum, 1931;Gaddum, 1953;Amin, Crawford & Gaddum, 1954).…”

Section: Introductionmentioning

confidence: 99%

Sixth Gaddum Memorial Lecture National Institute for Medical Research, Mill Hill, January 1977

Langer

1977

British J Pharmacology

915

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Section: Introductionmentioning

confidence: 99%

Sixth Gaddum Memorial Lecture National Institute for Medical Research, Mill Hill, January 1977

Langer

1977

British J Pharmacology

915

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“…In the mammalian gut, substance P (SP) is localized in nerve fibres around ganglionic cell bodies or in the smooth muscle layers (Euler & Gaddum, 1931;Gaddum & Schild, 1935;Nilsson, Larsson, Hakanson, Brodin, Pernow & Sundler, 1975;Pearse & Polak, 1975;Sundler, HAkanson, Larsson, Brodin & Nilsson, 1977;Franco, Costa & Furness, 1979), and may be released from the enteric plexus (Franco, et al, 1979).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Substance P on Smooth Muscle Cells and on Neuro‐effector Transmission in the Guinea‐pig Ileum

Fujisawa¹,

Ito²

1982

British J Pharmacology

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The effects of substance P (SP) on the membrane and contractile properties of the smooth muscle cell, or on neuro‐effector transmission in the guinea‐pig ileum were observed by means of microelectrodes, double sucrose gap and tension recording. SP (10−13‐10−10 M) induced a phasic contraction of longitudinal muscle strips, but did not change the muscle tone of circular muscle strips, in concentrations up to 10−8 M. SP (1010‐10‐8M) evoked three different membrane responses in longitudinal muscle cells: (i) bursts of spike discharges with no significant change in the membrane potential and input membrane resistance; (ii) bursts of spike discharges with a small but clear depolarization of the membrane and increase in the input membrane resistance; (iii) slow waves with no change in the membrane potential. In the circular muscle cells, low concentrations of SP (< 10−8M) did not affect the membrane potential or the spikes, but SP (10−7M) increased the spike discharges with no significant change in the membrane potential. SP (10−10M) reduced the threshold depolarization required for the generation of action potentials with no change in membrane potential of the longitudinal muscle cells. Pretreatment with atropine (5 × 10−6M), tetrodotoxin (TTX 10−6M) or baclofen (4.7 × 10−6M) had no effect on the excitatory actions of SP on the smooth muscle cells of longitudinal and circular muscle strips. Excitatory actions of SP on the membrane potential or spike activities of longitudinal muscle cells were preserved in NaCl but not in Ca‐deficient solution. SP (10−10‐10−9M) enhanced the amplitude of the excitatory junction potentials (e.j.ps) evoked by electrical field stimulation in longitudinal muscle cells with no change in the membrane potential and input resistance. SP (10−10‐10−9M), however, did not change the amplitude of inhibitory junction potentials (i.j.ps) recorded from the circular muscle cells. These results indicate that SP in relatively low concentrations acts on both smooth muscle cells and on excitatory neuro‐effector transmission in the longitudinal muscle; the main site of the action of SP is probably the muscle membrane.

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“…Substance P (SP) was identified first by its stimulant action on intestinal smooth muscle and by its vasodilator effect (Euler & Gaddum, 1931). Although both intestinal contraction and vasodilatation can be explained by a direct effect on smooth muscle cells, an action on autonomic neuroeffector transmission in these tissues cannot be excluded.…”

Section: Introductionmentioning

confidence: 99%

The influence of substance P on the response of guinea‐pig isolated ileum to periarterial nerve stimulation

Grbović

Radmanoviě

1983

British J Pharmacology

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An unidentified depressor substance in certain tissue extracts

Cited by 1,486 publications

References 7 publications

Sixth Gaddum Memorial Lecture National Institute for Medical Research, Mill Hill, January 1977

Sixth Gaddum Memorial Lecture National Institute for Medical Research, Mill Hill, January 1977

The Effects of Substance P on Smooth Muscle Cells and on Neuro‐effector Transmission in the Guinea‐pig Ileum

The influence of substance P on the response of guinea‐pig isolated ileum to periarterial nerve stimulation

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