An unexpected temporary suppression of lactation after a local corticosteroid injection for tenosynovitis

Babwah, Terence; Nunes, Paula; Maharaj, Rohan G

doi:10.3109/13814788.2013.805198

Cited by 16 publications

(6 citation statements)

References 6 publications

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“…This effect of GC on lactose synthesis, including the effect of exogenous GC, can be revealed in different models and states. For example, lactating humans who received an injection of exogenous GC for musculoskeletal pain had complete or near complete suppression of milk production within one day [98,99]. In the same way, synthetic GC administered to lactating cows reduced milk lactose concentration from 46 to 43 mg/ml within 24 h of treatment, concomitant with a decrease in milk yield of approximately 10 kg/d [100].…”

Section: Glucocorticoids (Gc)mentioning

confidence: 99%

A Comparative Review of the Extrinsic and Intrinsic Factors Regulating Lactose Synthesis

Sadovnikova

García

Hovey

2021

J Mammary Gland Biol Neoplasia

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Milk is critical for the survival of all mammalian offspring, where its production by a mammary gland is also positively associated with its lactose concentration. A clearer understanding of the factors that regulate lactose synthesis stands to direct strategies for improving neonatal health while also highlighting opportunities to manipulate and improve milk production and composition. In this review we draw a cross-species comparison of the extra- and intramammary factors that regulate lactose synthesis, with a special focus on humans, dairy animals, and rodents. We outline the various factors known to influence lactose synthesis including diet, hormones, and substrate supply, as well as the intracellular molecular and genetic mechanisms. We also discuss the strengths and limitations of various in vivo and in vitro systems for the study of lactose synthesis, which remains an important research gap.

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Section: Glucocorticoids (Gc)mentioning

confidence: 99%

A Comparative Review of the Extrinsic and Intrinsic Factors Regulating Lactose Synthesis

Sadovnikova

García

Hovey

2021

J Mammary Gland Biol Neoplasia

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“…However, the use of glucocorticoid can cause a temporary decrease of milk production in nursing mothers. Babwah et al [ 15 ] reported a case of temporary suppression of lactation with a nursing mother who was given local corticosteroid for treatment of tenosynovitis. In this case, we first performed a diagnostic II/IH nerve block with ropivacaine and dexamethasone.…”

Section: Discussionmentioning

confidence: 99%

Continuous Ilioinguinal-iliohypogastric Nerve Block for Groin Pain in a Breast-feeding Patient after Cesarean Delivery

Kim

Baik

et al. 2016

Korean J Pain

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Ilioinguinal and iliohypogastric (II/IH) nerve injury is one of the most common nerve injuries following pelvic surgery, especially with the Pfannenstiel incision. We present a case of intractable groin pain, successfully treated with a continuous II/IH nerve block. A 33-year-old woman, following emergency cesarean section due to cephalopelvic disproportion, presented numbness in left inguinal area and severe pain on the labia on the second postoperative day. The pain was burning, lancinating, and exacerbated by standing or movement. However, she didn't want to take additional medicine because of breast-feeding. A diagnostic II/IH nerve block produced a substantial decrease in pain. She underwent a continuous II/IH nerve block with a complete resolution of pain within 3 days. A continuous II/IH nerve block might be a goodoption for II/IH neuropathy with intractable groin pain in breast-feeding mothers without adverse drug reactions in their infants.

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“…Furthermore, there is negligible gut absorption from the baby, and so there is no significant risk of hypothalamus-pituitary-adrenal axis suppression. There are, however, documented cases of lactation suppression secondary to triamcinolone injection [17,18]. Corticosteroids are a substrate of the enzyme CYP3A4, which is targeted and blocked by many anti-retrovirals (ritonavir), anti-fungals, calcium-channel blockers (diltiazem), and the oral contraceptive pill, to name a few.…”

Section: Ia Corticosteroids—mechanism Of Actions and Pharmacokineticsmentioning

confidence: 99%

Musculoskeletal Corticosteroid Administration: Current Concepts

et al. 2019

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Numerous corticosteroid preparations are available, but the type and dose administered is frequently at the discretion of the clinician. This is often based on anecdotal evidence and experience rather than formal clinical guidelines. In order to better understand current practice, we anonymously surveyed 100 members of the British Society of Skeletal Radiologists. The results of the survey demonstrated the arbitrary use of all types of steroid preparation at different anatomical locations. In this article, we review the commonly used corticosteroids and propose a guideline to help practitioners decide on the type and dose of steroid depending on the treatment location.

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An unexpected temporary suppression of lactation after a local corticosteroid injection for tenosynovitis

Cited by 16 publications

References 6 publications

A Comparative Review of the Extrinsic and Intrinsic Factors Regulating Lactose Synthesis

A Comparative Review of the Extrinsic and Intrinsic Factors Regulating Lactose Synthesis

Continuous Ilioinguinal-iliohypogastric Nerve Block for Groin Pain in a Breast-feeding Patient after Cesarean Delivery

Musculoskeletal Corticosteroid Administration: Current Concepts

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