An Uncommon Presentation of Amyloidosis

Kujawski, Brandon; Johnson, Drew; Radadia, Kushan; Feduska, Eric; Ford, Robert E.; Uppal, Guldeep; Kabir, M Rashed Z; Stewart, John

doi:10.29046/tmf.015.1.004

Cited by 2 publications

(3 citation statements)

References 11 publications

(15 reference statements)

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“…CC-BY 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. (which was not certified by peer review) tion of each stage of the clinical progression of COVID-19 (15)(16)(17)(18)(19). Probabilities of symptoms, hospitalization, and death are specified by separate parameters (17,20).…”

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confidence: 99%

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Mobility trends provide a leading indicator of changes in SARS-CoV-2 transmission

Miller

Foti

Lewnard

et al. 2020

Preprint

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Determining the impact of non-pharmaceutical interventions on transmission of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is paramount for the design and deployment of effective public health policies. Incorporating Apple Maps mobility data into an epidemiological model of daily deaths and hospitalizations allowed us to estimate an explicit relationship between human mobility and transmission in the United States. We find that reduced mobility explains a large decrease in the effective reproductive number (R E ) attained by April 1st and further identify state-to-state variation 1 . CC-BY 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. (which was not certified by peer review)

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confidence: 99%

“…Leveraging the evidence that patients can be asymptomatic and positive for weeks (19), we fix the durations of the asymptomatic and symptomatic cohorts to be equal,…”

mentioning

confidence: 99%

Mobility trends provide a leading indicator of changes in SARS-CoV-2 transmission

Miller

Foti

Lewnard

et al. 2020

Preprint

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“…Механизм его развития не ясен. В качестве возможной причины рассматривают функциональный гипоспленизм вследствие замещения ткани селезенки амилоидом [15][16][17].…”

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Hemostasis disorders in patients with systemic AL-amyloidosis

Rekhtina,

Khyshova,

Zozulya

et al. 2023

Terapevticheskii arkhiv

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Aim. To analyze the frequency and nature of hemorrhagic and thrombotic complications in patients with systemic AL-amyloidosis and compare with laboratory changes in the hemostasis system. Materials and methods. The prospective study included 40 patients with newly diagnosed AL-amyloidosis. To detect amyloid, all patients underwent bone marrow trephine biopsy and duodenal biopsy, and 28 (70%) patients underwent biopsy of the affected organ. Before the start of therapy, all patients were determined the platelet count, activated partial thromboplastin time, thrombin time, fibrinogen concentration, time of XIIa-dependent fibrinolysis, antithrombin III, D-dimer, activity of blood coagulation factors VIII, X and vWF. The statistical part of the study was carried out using the IBM SPSS Statistics 2017 system software (SPSS, Chicago, IL, USA). Results. In 20 (50%) patients, hemorrhages on the skin and mucous membranes were diagnosed as vascular purpura. Before the start of therapy, 7 (17.5%) patients had thrombosis, including leg vein thrombosis (5 patients), ischemic stroke (2 patients). There was a direct correlation between thrombotic complications and cutaneous hemorrhagic syndrome (p=0.007). In 15 (75%) cases, cutaneous hemorrhagic syndrome was accompanied by hypercoagulable shifts in the hemostasis system. Of the 20 patients with cutaneous hemorrhagic syndrome, 19 (95%) patients had kidney damage, including 15 patients with nephrotic syndrome. Hematoma type of bleeding, as well as heavy bleeding was not observed, including after a biopsy of the internal organs. According to the totality of hemostasis indicators, hypercoagulation syndrome was more often observed (in 23; 56% of patients). Hypocoagulation was diagnosed only in 2 (5%) patients with liver damage, 16 (39%) patients had normocoagulation. Conclusion. Cutaneous hemorrhagic syndrome is the most common clinical manifestation of disorders in the hemostasis system in patients with AL-amyloidosis. The relationship of hemorrhages on the skin with nephrotic syndrome has been established, which may indicate a single pathogenetic mechanism. Cutaneous hemorrhagic syndrome is associated with hypercoagulable shifts in hemostasis and a high risk of thrombotic complications.

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An Uncommon Presentation of Amyloidosis

Cited by 2 publications

References 11 publications

Mobility trends provide a leading indicator of changes in SARS-CoV-2 transmission

Mobility trends provide a leading indicator of changes in SARS-CoV-2 transmission

Hemostasis disorders in patients with systemic AL-amyloidosis

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