An Uncommon Malignancy of the Breast; Dermatofibrosarcoma Protruberans- A Case Report

Rao, Chandrika; K, Jayaprakash Shetty; Hl, Kishan Prasad

doi:10.1007/s13193-012-0162-2

Cited by 4 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DFSP arising in the breast needs to be differentiated from other spindle cell lesions of the breast such as phyllodes tumor, fibromatosis, myoepithelioma, or metaplastic carcinoma [13]. Phyllodes tumors are biphasic by nature and exhibit hypercellular mesenchymal component surrounding benign breast ducts.…”

Section: Discussionmentioning

confidence: 99%

Dermatofibrosarcoma Protruberans of the Breast Skin Simulating Mammary Carcinoma

Shukla

Gulwani

2016

Indian J Surg Oncol

View full text Add to dashboard Cite

Dermatofibrosarcoma protuberans is a rare soft tissue sarcoma that arises from the dermis and invades deeper tissues. Usually, it behaves as an intermediate grade malignancy but in rare instances, it can metastasize. Frequent occurrences have been observed in trunk and extremities but involvement of the breast has rarely been reported. Therefore, dermatofibrosarcoma protuberans (DFSP) breast often masquerades primary breast malignancy on clinical and radiological grounds. Histomorphology and immunohistochemistry are helpful in making a definitive diagnosis. In the present case, monomorphic spindle cells were seen arranged in classical storiform pattern with large areas of myxoid change. Many times, such myxoid areas pose a diagnostic challenge and necessitate differentiation from other myxoid neoplasms. Herein, immunohistochemistry offers an advantage where tumor cells show strong reactivity for CD34 antibody. Wide surgical excision remains the treatment of choice. The salient clinical features, histogenesis, histomorphology, and immunohistochemical findings have been described with strong emphasis on the diagnostic and therapeutic management of this rare entity.

show abstract

Section: Discussionmentioning

confidence: 99%

Dermatofibrosarcoma Protruberans of the Breast Skin Simulating Mammary Carcinoma

Shukla

Gulwani

2016

Indian J Surg Oncol

View full text Add to dashboard Cite

show abstract

Primary and Secondary Dermatologic Disorders of the Breast

Carr¹,

Smith²,

Peters³

2018

The Breast

View full text Add to dashboard Cite

DFSP of the Breast: Histomorphological, Immunohistochemical, and Molecular Features of a Rare Case in an Unusual Location

Laharwani

Prakash²,

Walley³

et al. 2021

Applied Immunohistochemistry &Amp; Molecular Morphology

View full text Add to dashboard Cite

We present a case of a 21-year-old female with a vague nontender mass in the lower inner quadrant of the left breast discovered incidentally on chest imaging following trauma. A breast ultrasound demonstrated an 8×6×8 mm irregular hyperechoic mass at the 7 o'clock position of the left breast, 9 cm from the nipple. The mass was graded Breast Imaging Reporting and Data System (BI-RADS) category 4 (suspicious finding). An ultrasound-guided biopsy of the mass showed a proliferation of monotonous spindled cells in a storiform pattern with tapered nuclei with infiltration into the adipose tissue. No normal breast elements were identified in the biopsy. Myofibroblastoma was the first differential diagnosis; however, the characteristic infiltrative pattern of the tumor mandated additional tests including fluorescence in situ hybridization to rule out a dermatofibrosarcoma protruberance (DFSP). Immunohistochemical staining showed positive staining for CD34, which can be positive in myofibroblastoma also. However, fluorescence in situ hybridization demonstrated a platelet-derived growth factor B (22q13.1) gene rearrangement confirming a diagnosis of DFSP. The patient underwent a wide local excision of the DFSP for definitive treatment. She is doing well with no recurrence reported so far, after 15 months of follow-up. Conventional DFSP does not metastasize but is prone to recurrence making wide margins imperative for definitive treatment.

show abstract

An Uncommon Malignancy of the Breast; Dermatofibrosarcoma Protruberans- A Case Report

Cited by 4 publications

References 8 publications

Dermatofibrosarcoma Protruberans of the Breast Skin Simulating Mammary Carcinoma

Dermatofibrosarcoma Protruberans of the Breast Skin Simulating Mammary Carcinoma

Primary and Secondary Dermatologic Disorders of the Breast

DFSP of the Breast: Histomorphological, Immunohistochemical, and Molecular Features of a Rare Case in an Unusual Location

Contact Info

Product

Resources

About