An umbrella review of the evidence associating diet and cancer risk at 11 anatomical sites

Papadimitriou, Nikos; Markozannes, Georgios; Kanellopoulou, Afroditi; Critselis, Elena; Alhardan, Sumayah; Karafousia, Vaia; Kasimis, John C.; Katsaraki, Chrysavgi; Papadopoulou, Areti; Zografou, Maria; López, David S.; Chan, Doris S. M.; Kyrgiou, Maria; Ntzani, Evangelia; Cross, Amanda J.; Marrone, Michael; Platz, Elizabeth A.; Gunter, Marc J.; Tsilidis, Konstantinos K.

doi:10.1038/s41467-021-24861-8

Cited by 121 publications

(105 citation statements)

References 65 publications

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“…157,158 Recent extensive meta-analyses' have confirmed these trends and reported a strong association of colorectal cancer risk with dietary pattern and specifically with a low fiber, high fat and simple sugar containing diet. 159,160 Although there are several possible theories through which the anti-colon-cancer effect of the high fiber diet is thought to be mediated, the evidence from in-vitro studies have shown that butyrate plays a major role as an important intermediary metabolite in this pathway. 140,161,162 More research is needed to show the direct effects of gut microbially generated butyrate on anticolon cancer effects.…”

Section: Dovepressmentioning

confidence: 99%

The Immunomodulatory Functions of Butyrate

Siddiqui¹,

Cresci²

2021

JIR

158

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Section: Dovepressmentioning

confidence: 99%

The Immunomodulatory Functions of Butyrate

Siddiqui¹,

Cresci²

2021

JIR

158

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“…With regard to cancer incidence, a recent umbrella review concluded that there was sufficient evidence to conclude that several foods or nutrients were associated with cancer risk [6]. For instance, strong evidence was found for whole grains in relation to colorectal cancer risk.…”

Section: Introductionmentioning

confidence: 99%

The Role of Diet, Alcohol, BMI, and Physical Activity in Cancer Mortality: Summary Findings of the EPIC Study

et al. 2021

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Evidence on the impact of diet, alcohol, body-mass index (BMI), and physical activity on mortality due to cancer and other cancer-related outcomes is still scarce. Herein, we reviewed the contribution of the European Prospective Investigation into Cancer and Nutrition (EPIC) study to the current state of the art on the role of these factors in cancer mortality. We identified 45 studies using a rapid systematic review methodology. Dietary factors associated with reduced cancer mortality included raw vegetable intake; dietary fiber intake; the Mediterranean diet; other dietary scores; other diet patterns including low meat eaters, vegetarians/vegans, or fish eaters; dietary intake (or biomarkers) of some vitamins (e.g., vitamin D, vitamin K2, or Vitamin C); and intake of lignans. Physical activity and following healthy lifestyle recommendations also reduced cancer mortality risk. In contrast, dietary factors associated with higher cancer mortality risk included poor diet quality, consumption of alcohol and soft drinks including juice, and, to a lesser extent, intake of some fatty acids. Excess weight and obesity also increased the risk of cancer mortality. The EPIC study holds valuable information on diet and lifestyle factors and offers a unique opportunity to identify key diet-related factors for cancer mortality prevention.

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“…In a previous study, Papadimitriou and colleagues performed an umbrella review of evidence on the association of diet with the risk of 11 cancers (including RCC) [ 178 ]. The present study differs from their study in the following ways: (1) their literature was searched through March 2013, whereas ours was searched through April 2021; (2) the databases searched were not identical; (3) the present study included more recent meta-analyses and included more exposures (64 v 24), such as dietary inflammatory index, glycemic index, vitamin D, and riboflavin; (4) their study did not exclude overlapping SRoMAs and therefore, was likely to include duplicate individual studies, resulting in biased results and associations [ 46 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

The role of diet in renal cell carcinoma incidence: an umbrella review of meta-analyses of observational studies

Liao

Fang

Gou

et al. 2022

BMC Med

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Background Evidence associating diet with the incidence of renal cell carcinoma (RCC) is inconclusive. We aimed to summarize evidence associating dietary factors with RCC incidence and assess the strength and validity of this evidence. Methods We conducted an umbrella review of systematic reviews or meta-analyses (SRoMAs) that assessed the association between diet and RCC incidence. Through April 2021, PubMed, Web of Science, Embase, The Cochrane Library, Scopus, and WCRF were searched. Two independent reviewers selected studies, extracted data, and appraised the quality of SRoMAs. According to credibility assessment criteria, evidence can be divided into five categories: convincing (class I), highly suggestive (class II), suggestive (class III), weak (class IV), and nonsignificant (class V). Results Twenty-nine meta-analyses were obtained after screening. After excluding 7 overlapping meta-analyses, 22 meta-analyses including 502 individual studies and 64 summary hazard ratios for RCC incidence were included: dietary patterns or dietary quality indices (n = 6), foods (n = 13), beverages (n = 4), alcohol (n = 7), macronutrients (n =15), and micronutrients (n =19). No meta-analyses had high methodological quality. Five meta-analyses exhibited small study effects; one meta-analysis showed evidence of excess significance bias. No dietary factors showed convincing or highly suggestive evidence of association with RCC in the overall analysis. Two protective factors had suggestive evidence (vegetables (0.74, 95% confidence interval 0.63 to 0.86) and vitamin C (0.77, 0.66 to 0.90)) in overall analysis. One protective factor had convincing evidence (moderate drinking (0.77, 0.70 to 0.84)) in Europe and North America and one protective factor had highly suggestive evidence (cruciferous vegetables (0.78, 0.70 to 0.86)) in North America. Conclusions Although many meta-analyses have assessed associations between dietary factors and RCC, no high-quality evidence exists (classes I and II) in the overall analysis. Increased intake of vegetables and vitamin C is negatively associated with RCC risk. Moderate drinking might be beneficial for Europeans and North Americans, and cruciferous vegetables might be beneficial to North Americans, but the results should be interpreted with caution. More researches are needed in the future. Trial registration PROSPERO CRD42021246619

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An umbrella review of the evidence associating diet and cancer risk at 11 anatomical sites

Cited by 121 publications

References 65 publications

The Immunomodulatory Functions of Butyrate

The Immunomodulatory Functions of Butyrate

The Role of Diet, Alcohol, BMI, and Physical Activity in Cancer Mortality: Summary Findings of the EPIC Study

The role of diet in renal cell carcinoma incidence: an umbrella review of meta-analyses of observational studies

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