An Ultrasound-Activated Nanozyme Sonosensitizer for Photoacoustic Imaging-Guided Breast Cancer Sonodynamic and Starvation Combination Therapy

Abstract

Sonodynamic therapy (SDT) is a promising ultrasound (US)triggered therapeutic modality for anticancer treatments due to its high penetration, safety, and noninvasiveness. Its therapeutic efficiency is closely related to the performance of sonosensitizers and the oxygen concentration of the tumor microenvironment (TME). Herein, inspired by the adhesion of cocklebur, a rough-surface sonosensitizer gold platinum encapsulated with magnesium silicate loaded with glucose oxidase (AuPt@MgSiO 3 @GOx, APMS-GOx) with an enzymatic cascade activity was designed to improve delivery capability, produce reactive oxygen species, and reduce the glucose concentration in tumor tissue. The rough surface of APMS-GOx can improve the ability of nanomaterials to deliver to tumor areas. The enzymatic cascade reaction of APMS-GOx can induce starvation therapy and improve the level of oxygen. Adequate oxygen can not only alleviate hypoxia TME but also further convert to singlet oxygen ( 1 O 2 ) by APMS-GOx under US activation. Moreover, the activity of GOx increases due to the involvement of US, resulting in a positive effect on starvation therapy. Furthermore, APMS-GOx exhibits near-infrared absorption properties, providing a photoacoustic imaging-guided combination breast tumor therapy strategy.

Ultrasonic Diagnosis and Treatment of Tumors Using Multifunctional Hollow Mesoporous Silicon Nanoparticles

“…It works by the synergistic effect of ultrasound (US) and sonosensitizer to generate toxic ROS and kill tumor cells . Nanoparticles play a crucial role in transporting the sonosensitizer to the tumor tissue, enhancing the accumulation of ROS in the tumor tissue and ultimately improving the efficacy of tumor treatment. − Ultrasound has the advantages of noninvasiveness, high tissue penetration capability, and organ/tissue specificity. , Combining nanoparticles with ultrasound have shown promising results in the precise diagnosis and effective treatment of tumors. − …”