An Ultrasonogram Reporting System for Thyroid Nodules Stratifying Cancer Risk for Clinical Management

Horvath, Eleonora; Majlis, Sergio; Rossi, Ricardo L.; Franco, Carmen; Niedmann, Juan Pablo; Castro, Álex; Domínguez, Miguel

doi:10.1210/jc.2008-1724

Cited by 795 publications

(798 citation statements)

References 13 publications

(12 reference statements)

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“…There are recent efforts to stratify thyroid nodules in categories of probability of malignancy based on the estimated risks of various ultrasound characteristics 15 , 23 . Such a reporting system may facilitate communication of thyroid cancer risk particularly when multiple nodules are present and provide clearer guidelines for using FNAB.…”

Section: Thyroid Ultrasound Reportmentioning

confidence: 99%

Thyroid nodules and evaluation of thyroid cancer risk

Hoang

2010

Australas J Ultrason Med

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Section: Thyroid Ultrasound Reportmentioning

confidence: 99%

Thyroid nodules and evaluation of thyroid cancer risk

Hoang

2010

Australas J Ultrason Med

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“…Several authors (7)(8)(9)(10)(11)(12) have proposed different Thyroid Imaging Reporting and Data System (TI-RADS) classifications to standardize thyroid ultrasound reports, as demonstrated with the Breast Imaging Reporting and Data System (BI-RADS ® ) (13). Researchers have recently attempted to validate this type of approach as an instrument for use in clinical practice, with some authors proposing different TI-RADS versions in selected populations (14)(15)(16)(17)(18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

Likelihood of malignancy in thyroid nodules according to a proposed Thyroid Imaging Reporting and Data System (TI-RADS) classification merging suspicious and benign ultrasound features

Delfim

Veiga

Vidal

et al. 2017

Arch. Endocrinol. Metab.

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Objective: The aim of this study was to describe the ultrasound features of benign and malignant thyroid nodules and evaluate the likelihood of malignancy associated with each feature according to the Bethesda System for Reporting Thyroid Cytopathology and histopathology. With this analysis, we propose a new TI-RADS classification system. Materials and methods: The likelihood of malignancy from ultrasound features were assessed in 1413 thyroid nodules according to the Bethesda System for Reporting Thyroid Cytopathology and histopathological findings. A score was established by attributing different weights to each ultrasound feature evaluated. Results: Features positively associated with malignancy in bivariate analysis received a score weight of +1. We attributed a weight of +2 to features which were independently associated with malignancy in a multivariate analysis and +3 for those associated with the highest odds ratio for malignancy (> 10.0). Hence, hypoechogenicity (graded as mild, moderate or marked, according to a comparison with the overlying strap muscle), microcalcification and irregular/microlobulated margin received the highest weights in our scoring system. Features that were negatively associated with malignancy received weights of -2 or -1. In the proposed system a cutoff score of 2 (sensitivity 97.4% and specificity 51.6%) was adopted as a transition between probably benign (TI-RADS 3) and TI-RADS 4a nodules. Overall, the frequency of malignancy in thyroid nodules according to the categories was 1.0% for TI-RADS 3, 7.8% for TI-RADS 4a, 35.3% for TI-RADS 4b, and 84.7% for TI-RADS 5. Conclusion: A newly proposed TI-RADS classification adequately assessed the likelihood of malignancy in thyroid nodules. Arch Endocrinol Metab. 2017;61(3):211-21.

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“…Since in our study, assessment was performed retrospectively, and power Doppler or color-coded Doppler ultrasound results were not available for all malignant or benign nodules, we did not consider nodule perfusion as a criterion. Consequently, our study could not classify nodules detected during the ultrasound examination following a TIR-ADS breakdown, since perfusion behavior is a component of this classification method [20]. Since the study in which the TIRADS classification was initially suggested, no differentiation was made between perfusion behavior of PTC and FTC, it would be useful to examine this criterion in a future study.…”

mentioning

confidence: 98%

Differential Diagnostic Ultrasound Criteria of Papillary and Follicular Carcinomas: A Multivariate Analysis

Cordes

Kondrat

Uder

et al. 2014

Fortschr Röntgenstr

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An Ultrasonogram Reporting System for Thyroid Nodules Stratifying Cancer Risk for Clinical Management

Abstract: The TIRADS has allowed us to improve patient management and cost-effectiveness, avoiding unnecessary FNAB. In addition, we have established standard codes to be used both for radiologists and endocrinologists.

Cited by 795 publications

References 13 publications

Thyroid nodules and evaluation of thyroid cancer risk

Thyroid nodules and evaluation of thyroid cancer risk

Likelihood of malignancy in thyroid nodules according to a proposed Thyroid Imaging Reporting and Data System (TI-RADS) classification merging suspicious and benign ultrasound features

Differential Diagnostic Ultrasound Criteria of Papillary and Follicular Carcinomas: A Multivariate Analysis

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