An ultrasensitive label-free electrochemical impedimetric immunosensor for vascular endothelial growth factor based on specific phage via negative pre-screening

Wang, Mingyang; Zheng, Zongmei; Zhang, Yaru; Wang, Ge; Liu, Junchong; Yu, Haipeng; Liu, Aihua

doi:10.1016/j.aca.2022.340250

Cited by 9 publications

(5 citation statements)

References 38 publications

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“…A VEGF165 EIS immunosensor was then constructed with the specific phage‐modified electrode. As obtained from the EIS results, it has been shown that the electron transfer resistance (ΔR et ) value increases with increasing VEGF165 protein concentration [34]. Barhoum et al.…”

Section: Concept Of Non‐invasive Electrochemical Immunosensor Designmentioning

confidence: 93%

“…A VEGF165 EIS immunosensor was then constructed with the specific phage-modified electrode. As obtained from the EIS results, it has been shown that the electron transfer resistance (ΔR et ) value increases with increasing VEGF165 protein concentration [34]. Barhoum et al developed an immunosensor for the impedimetric determination of MiniChromosome Maintenance Protein 5 (MCM5), a cervical cancer biomarker (Figure 2C).…”

Section: Concept Of Non-invasive Electrochemical Immunosensor Design ...mentioning

confidence: 99%

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The role of nanoparticles in non‐invasive electrochemical immunosensor technology and recent developments

Sanko,

Erkmen,

Kuralay

2024

Electroanalysis

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Section: Concept Of Non‐invasive Electrochemical Immunosensor Designmentioning

confidence: 93%

Section: Concept Of Non-invasive Electrochemical Immunosensor Design ...mentioning

confidence: 99%

The role of nanoparticles in non‐invasive electrochemical immunosensor technology and recent developments

Sanko,

Erkmen,

Kuralay

2024

Electroanalysis

View full text Add to dashboard Cite

show abstract

“…Because of its good interface characterization, a small amplitude voltage or current will not interfere with the biological macromolecules on the electrode surface; therefore, it can be employed as a preferred test technique to construct impedimetric immunosensors. [65][66][67] Compared with other electrochemical immune techniques, the impedimetric electrochemical immunosensor shows high analytical sensitivity, accuracy, and stability, with no requirement for labeling the target or using secondary signal amplification. The most commonly used route for the immobilization of biomolecules in impedimetric immunosensors is self-assembly.…”

Section: Electrochemical Immunosensorsmentioning

confidence: 99%

Recent Progress on Nanomaterial‐Facilitated Electrochemical Strategies for Cancer Diagnosis

Yuan

Lin

Liu

et al. 2023

Adv Healthcare Materials

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Cancer is a malignant disease that endangers human life, especially owing to its high fatality rate; therefore, rapid and accurate early screening is needed to effectively improve the survival rate. Compared with traditional cancer detection methods, electrochemical biosensors that recognize cancer biomarkers in blood have the advantages of low invasiveness, fast diagnosis, and low cost. However, there is always a trade‐off between sensitivity and selectivity, which limits the detection of trace amounts of biomarkers produced in the early stages. To address this issue, an increasing number of nanomaterials with simultaneous improvements in both sensitivity and selectivity have recently been reported. In this review, different categories of state‐of‐the‐art electrochemical biosensors and their operating principles are introduced, and their respective advantages and disadvantages are described. Furthermore, the review discusses the existing detection strategies and performance of nanomaterial‐based cancer biosensors for biomarker recognition, providing overall guidance for the material selection of different biomarkers. Finally, the main challenges involving existing electrochemical cancer biosensors are evaluated to present the future development prospects of nanomaterials and detection strategies.

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“…This innovative approach holds great promise for the ultra-sensitive detection of various proteins, opening up new possibilities for a range of applications. In a subsequent breakthrough, Mingyang Wang and their research team ( 109 ) introduced a screening strategy for VEGF members with a structural resemblance to VEGF165, considering its potential as a therapeutic target for various malignancies. Their aim was to significantly enhance the specificity of the selected phage monoclonal.…”

Section: Preparation and Functionalization Of Nano Immunosensorsmentioning

confidence: 99%

Advances in phage display based nano immunosensors for cholera toxin

Li,

Yang,

Kong

et al. 2023

Front. Immunol.

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Cholera, a persistent global public health concern, continues to cause outbreaks in approximately 30 countries and territories this year. The imperative to safeguard water sources and food from Vibrio cholerae, the causative pathogen, remains urgent. The bacterium is mainly disseminated via ingestion of contaminated water or food. Despite the plate method’s gold standard status for detection, its time-consuming nature, taking several days to provide results, remains a challenge. The emergence of novel virulence serotypes raises public health concerns, potentially compromising existing detection methods. Hence, exploiting Vibrio cholerae toxin testing holds promise due to its inherent stability. Immunobiosensors, leveraging antibody specificity and sensitivity, present formidable tools for detecting diverse small molecules, encompassing drugs, hormones, toxins, and environmental pollutants. This review explores cholera toxin detection, highlighting phage display-based nano immunosensors’ potential. Engineered bacteriophages exhibit exceptional cholera toxin affinity, through specific antibody fragments or mimotopes, enabling precise quantification. This innovative approach promises to reshape cholera toxin detection, offering an alternative to animal-derived methods. Harnessing engineered bacteriophages aligns with ethical detection and emphasizes sensitivity and accuracy, a pivotal stride in the evolution of detection strategies. This review primarily introduces recent advancements in phage display-based nano immunosensors for cholera toxin, encompassing technical aspects, current challenges, and future prospects.

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An ultrasensitive label-free electrochemical impedimetric immunosensor for vascular endothelial growth factor based on specific phage via negative pre-screening

Cited by 9 publications

References 38 publications

The role of nanoparticles in non‐invasive electrochemical immunosensor technology and recent developments

The role of nanoparticles in non‐invasive electrochemical immunosensor technology and recent developments

Recent Progress on Nanomaterial‐Facilitated Electrochemical Strategies for Cancer Diagnosis

Advances in phage display based nano immunosensors for cholera toxin

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