An ultrasensitive electrochemical immunosensor based on the catalytical activity of MoS2-Au composite using Ag nanospheres as labels

Xiu, Wang; Chu, Chengchao; Shen, Lei; Deng, Wenli; Yan, Mei; Ge, Shenguang; Yu, Jinghua; Song, Xianrang

doi:10.1016/j.snb.2014.09.028

Cited by 106 publications

(40 citation statements)

References 39 publications

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“…By the incorporation of GOD, they further extended this system as a transducer platform for glucose sensing . An electrochemical sandwich immunosensor based on the MoS 2 –Au composite was also fabricated and used for the detection of carcinoembryonic antigen (CEA) ( Figure a) . The large surface area of the MoS 2 –Au composite makes it an excellent carrier to load more active probes and domains for binding biomolecules, providing a significant amplification of electrochemical sensing signals .…”

Section: Tmd Nanosheets and Their Composite‐based Electrochemical Senmentioning

confidence: 99%

See 1 more Smart Citation

Recent Advances in Sensing Applications of Two‐Dimensional Transition Metal Dichalcogenide Nanosheets and Their Composites

Ping

Fan

Sindoro

et al. 2017

Adv Funct Materials

218

136

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of 18) 1605817As a newly emerging class of nanomaterials, 2D TMD nanosheets possess a unique layered structure and large surface areas, as well as outstanding physical, chemical, optical, and electronic properties, which holds great potential for applications in catalysis, [37] sensing, [38] optics, [39] and energy. [40] In this review, we will focus on the introduction of state of the art sensing applications for 2D TMD nanosheets and their composites. In particular, different sensing strategies together with signal-transducing mechanisms in sensors based on 2D TMD nanosheets and their composites are thoroughly discussed. Our aim is to demonstrate a complete concept in this rapidly emerging research area and to address basic knowledge, opportunities, and challenges in this promising field. We expect that more 2D TMD nanosheets and their composites, as well as more sensing strategies, will be explored in this research field, enabling the fabrication of more accurate sensing devices for practical applications. TMD Nanosheets and Their Composite-Based Electrochemical SensorsThe electrochemical method has been extensively recognized as a powerful tool for fast access to biochemical information in complex samples due to its easy operation, fast response, high sensitivity, and low cost. Inspired by the use of graphene as transducers in electrochemical sensors, [41][42][43] researchers have attempted to use 2D TMD nanosheets as a transducer layer. Their good conductivity, large surface area, fast electron transfer kinetics, high signal/noise ratio, and, more importantly, their feasibility for forming composites, make 2D TMD nanosheets attractive as for electrochemical sensors. [44][45][46][47][48][49][50] Table 1 summarizes the recent progress of electrochemical sensors based on 2D TMD nanosheets and their composites. TMD Nanosheets as a Transducer Layer in Electrochemical SensorsIn 2012, our group developed a single-layer TMD-nanosheetbased electrochemical sensor, in which a single-layer MoS 2nanosheet-modified glassy carbon electrode was directly used for selective detection of dopamine in the presence of uric acid Two-dimensional (2D) transition metal dichalcogenide (TMD) nanosheets, such as MoS 2 , WS 2 , etc., are attracting increasing interest due to their intriguing physical, chemical, electronic, and optical properties. Success in development of methods for large-scale production of 2D TMD nanosheets and their composites has given great potential for various novel applications. In this review, recent progress in sensing applications of 2D TMD nanosheets and their composites is introduced. Moreover, different sensing strategies and signal-transducing mechanisms for sensing devices based on 2D TMD nanosheets and their composites are also summarized and discussed.

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Section: Tmd Nanosheets and Their Composite‐based Electrochemical Senmentioning

confidence: 99%

“…a) Schematic illustration of the fabrication process of an electrochemical immunosensor based on the catalytic activity of a MoS 2 –Au composite for the detection of carcinoembryonic antigen (CEA). Reproduced with permission . Copyright 2015, Elsevier.…”

Section: Tmd Nanosheets and Their Composite‐based Electrochemical Senmentioning

confidence: 99%

Recent Advances in Sensing Applications of Two‐Dimensional Transition Metal Dichalcogenide Nanosheets and Their Composites

Ping

Fan

Sindoro

et al. 2017

Adv Funct Materials

218

136

View full text Add to dashboard Cite

show abstract

“…For example, Wang et al [85] has reported an AgNPs-labeled immunosensor based on MoS 2 -Au composite film for carcino-embryonic antigen (CEA) detection (Figure 7). …”

Section: Electrochemical Immunosensors Based On Various Nanomaterialsmentioning

confidence: 99%

Nanomaterials for Electrochemical Immunosensing

Pan

Yun

et al. 2017

Sensors

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Electrochemical immunosensors resulting from a combination of the traditional immunoassay approach with modern biosensors and electrochemical analysis constitute a current research hotspot. They exhibit both the high selectivity characteristics of immunoassays and the high sensitivity of electrochemical analysis, along with other merits such as small volume, convenience, low cost, simple preparation, and real-time on-line detection, and have been widely used in the fields of environmental monitoring, medical clinical trials and food analysis. Notably, the rapid development of nanotechnology and the wide application of nanomaterials have provided new opportunities for the development of high-performance electrochemical immunosensors. Various nanomaterials with different properties can effectively solve issues such as the immobilization of biological recognition molecules, enrichment and concentration of trace analytes, and signal detection and amplification to further enhance the stability and sensitivity of the electrochemical immunoassay procedure. This review introduces the working principles and development of electrochemical immunosensors based on different signals, along with new achievements and progress related to electrochemical immunosensors in various fields. The importance of various types of nanomaterials for improving the performance of electrochemical immunosensor is also reviewed to provide a theoretical basis and guidance for the further development and application of nanomaterials in electrochemical immunosensors.

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“…Ag nanoparticle-containing nanocomposites are also useful as components of electrochemical biosensors. Ag nanoparticles/glucose oxidase (GOx) nanocomposite has been used to construct CEA immunosensors [37]. The sensor exhibits a voltammetric response to 0.001–50 ng·mL −1 of CEA upon adding glucose to the sample solutions.…”

Section: Immunosensors For Glycoproteinsmentioning

confidence: 99%

Recent Progress in Electrochemical Biosensors for Glycoproteins

Akiba

Anzai

2016

Sensors

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This review provides an overview of recent progress in the development of electrochemical biosensors for glycoproteins. Electrochemical glycoprotein sensors are constructed by combining metal and carbon electrodes with glycoprotein-selective binding elements including antibodies, lectin, phenylboronic acid and molecularly imprinted polymers. A recent trend in the preparation of glycoprotein sensors is the successful use of nanomaterials such as graphene, carbon nanotube, and metal nanoparticles. These nanomaterials are extremely useful for improving the sensitivity of glycoprotein sensors. This review focuses mainly on the protocols for the preparation of glycoprotein sensors and the materials used. Recent improvements in glycoprotein sensors are discussed by grouping the sensors into several categories based on the materials used as recognition elements.

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An ultrasensitive electrochemical immunosensor based on the catalytical activity of MoS2-Au composite using Ag nanospheres as labels

Cited by 106 publications

References 39 publications

Recent Advances in Sensing Applications of Two‐Dimensional Transition Metal Dichalcogenide Nanosheets and Their Composites

Recent Advances in Sensing Applications of Two‐Dimensional Transition Metal Dichalcogenide Nanosheets and Their Composites

Nanomaterials for Electrochemical Immunosensing

Recent Progress in Electrochemical Biosensors for Glycoproteins

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