An
            <scp>LTR</scp>
            retrotransposon‐derived lnc
            <scp>RNA</scp>
            interacts with
            <scp>RNF</scp>
            169 to promote homologous recombination

Deng, Bing; Xu, Wenli; Wang, Zelin; Liu, Chang; Lin, Penghui; Li, Bin; Huang, Qiao-Juan; Yang, Jianhua; Zhou, Hui; Qu, Liang‐Hu

doi:10.15252/embr.201847650

Cited by 30 publications

(15 citation statements)

References 77 publications

(151 reference statements)

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“…Interestingly, LINC01419 was linked to cell cycle regulation by co-expression network analysis. This has been validated recently [120]. Further, LINC01419, renamed as PRLH1 (p53-regulated lncRNA for homologous recombination (HR) repair 1), was found to promote cell proliferation in p53-mutated HCC cells by acting as a platform for the HR machinery of DNA damage repair, favoring progression in the cell cycle.…”

Section: Lncrnas Related To Hcv-related Hepatocellular Carcinoma (Hcvmentioning

confidence: 78%

LncRNAs in HCV Infection and HCV-Related Liver Disease

Unfried¹,

Fortes²

2020

IJMS

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Long non-coding RNAs (lncRNAs) are transcripts with poor coding capacity that may interact with proteins, DNA, or other RNAs to perform structural and regulatory functions. The lncRNA transcriptome changes significantly in most diseases, including cancer and viral infections. In this review, we summarize the functional implications of lncRNA-deregulation after infection with hepatitis C virus (HCV). HCV leads to chronic infection in many patients that may progress to liver cirrhosis and hepatocellular carcinoma (HCC). Most lncRNAs deregulated in infected cells that have been described function to potentiate or block the antiviral response and, therefore, they have a great impact on HCV viral replication. In addition, several lncRNAs upregulated by the infection contribute to viral release. Finally, many lncRNAs have been described as deregulated in HCV-related HCC that function to enhance cell survival, proliferation, and tumor progression by different mechanisms. Interestingly, some HCV-related HCC lncRNAs can be detected in bodily fluids, and there is great hope that they could be used as biomarkers to predict cancer initiation, progression, tumor burden, response to treatment, resistance to therapy, or tumor recurrence. Finally, there is high confidence that lncRNAs could also be used to improve the suboptimal long-term outcomes of current HCC treatment options.

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Section: Lncrnas Related To Hcv-related Hepatocellular Carcinoma (Hcvmentioning

confidence: 78%

LncRNAs in HCV Infection and HCV-Related Liver Disease

Unfried¹,

Fortes²

2020

IJMS

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“…PRLH1 (p53-regulated lncRNA for HR repair 1) is an example of a direct regulator of DSB repair at the site of the break. PRLH1 is p53 regulated and functions in DSB repair pathway choice through its ability to bind RNF169 [ 69 ], an E3 ubiquitin ligase, a paralogue of the RNF168. The complex of PRLH1 and RNF169 competes with 53BP1 for binding to RNF168 ubiquitinated chromatin, repressing NHEJ and promoting HR.…”

Section: Lncrnas: Direct and Indirect Regulators Of Dsb Repairmentioning

confidence: 99%

“…The complex of PRLH1 and RNF169 competes with 53BP1 for binding to RNF168 ubiquitinated chromatin, repressing NHEJ and promoting HR. Knockdown of PRLH1 reduces RNF169 levels, suggesting PRLH1 can regulate HR-mediated DSB repair through stabilisation of RNF169 [ 69 , 70 ]. Consequently, overexpression of PRLH1 lncRNA can promote HR-mediated DSB repair [ 69 , 71 ].…”

Section: Lncrnas: Direct and Indirect Regulators Of Dsb Repairmentioning

confidence: 99%

“…Knockdown of PRLH1 reduces RNF169 levels, suggesting PRLH1 can regulate HR-mediated DSB repair through stabilisation of RNF169 [ 69 , 70 ]. Consequently, overexpression of PRLH1 lncRNA can promote HR-mediated DSB repair [ 69 , 71 ]. LncRNA HIF-1a inhibitor at translational level (HITT) is another example of a direct DSB regulator.…”

Section: Lncrnas: Direct and Indirect Regulators Of Dsb Repairmentioning

confidence: 99%

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Jack of all trades? The versatility of RNA in DNA double-strand break repair

Ketley

Gullerová

2020

Essays in Biochemistry

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Abstract The mechanisms by which RNA acts in the DNA damage response (DDR), specifically in the repair of DNA double-strand breaks (DSBs), are emerging as multifaceted and complex. Different RNA species, including but not limited to; microRNA (miRNA), long non-coding RNA (lncRNA), RNA:DNA hybrid structures, the recently identified damage-induced lncRNA (dilncRNA), damage-responsive transcripts (DARTs), and DNA damage-dependent small RNAs (DDRNAs), have been shown to play integral roles in the DSB response. The diverse properties of these RNAs, such as sequence, structure, and binding partners, enable them to fulfil a variety of functions in different cellular contexts. Additionally, RNA can be modified post-transcriptionally, a process which is regulated in response to cellular stressors such as DNA damage. Many of these mechanisms are not yet understood and the literature contradictory, reflecting the complexity and expansive nature of the roles of RNA in the DDR. However, it is clear that RNA is pivotal in ensuring the maintenance of genome integrity. In this review, we will discuss and summarise recent evidence which highlights the roles of these various RNAs in preserving genomic integrity, with a particular focus on the emerging role of RNA in the DSB repair response.

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“…This original research lays the foundation for the concepts of exosome andexosomal RNA. Most recently, Dr. Lianghu Qu's team discovered the LTR retrotransposon-derived lncRNAs involved in DNA HR repairosome to regulate DNA repair and genome integrity (Deng et al, 2019).…”

mentioning

confidence: 99%