An RGD modified water-soluble fluorophore probe for <i>in vivo</i> NIR-II imaging of thrombosis

Wu, Yuanyuan; Wang, Chao; Guo, Jiaqi; Carvalho, Abdlay; Yao, Yuyu; Sun, Pengfei; Fan, Quli

doi:10.1039/d0bm00729c

Cited by 21 publications

(23 citation statements)

References 26 publications

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“…In addition, to form supramolecular complexes of host-guest or protein-fluorophore is another way to optimize the fluorophore's brightness. 69 , 70 , 71 , 72 …”

Section: Design Principles and Common Cores For Small Molecular Nir-ii Fluorophoresmentioning

confidence: 99%

Small Molecular NIR-II Fluorophores for Cancer Phototheranostics

et al. 2021

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Summary Phototheranostics integrates deep-tissue imaging with phototherapy (containing photothermal therapy and photodynamic therapy), holding great promise in early diagnosis and precision treatment of cancers. Recently, second near-infrared (NIR-II) fluorescence imaging exhibits the merits of high accuracy and specificity, as well as real-time detection. Among the NIR-II fluorophores, organic small molecular fluorophores have shown superior properties in the biocompatibility, variable structure, and tunable emission wavelength than the inorganic NIR-II materials. What's more, some small molecular fluorophores also display excellent cytotoxicity when illuminated with the NIR laser. This review summarizes the progress of small molecular NIR-II fluorophores with different central cores for cancer phototheranostics in the past few years, focusing on the molecular structures and phototheranostic performances. Furthermore, challenges and prospects of future development toward clinical translation are discussed.

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“…In addition, to form supramolecular complexes of host-guest or protein-fluorophore is another way to optimize the fluorophore's brightness. 69 , 70 , 71 , 72 …”

Section: Design Principles and Common Cores For Small Molecular Nir-ii Fluorophoresmentioning

confidence: 99%

Small Molecular NIR-II Fluorophores for Cancer Phototheranostics

et al. 2021

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“…Furthermore, TB1 was covalently grafted with tumor-specific c-RGD peptide to form TB1-RGD dots, targeting α v β 3 integrin receptors overexpressed in glioma and thus acted as a multimodal imaging contrast agent for NIR-II fluorescence imaging and NIR-I PAI of brain tumor (Sheng et al, 2018). Sun and coworkers reported the synthesis of a similar c-RGD peptide linkage NIR-II fluorescence probe called TTQ-PEG-cRGD based on S-D-A-D-S scaffold, with high fluorescent intensity in the NIR-II region and in vivo imaging targeted activated platelets GPIIb/IIa in early thrombus capable of distinguishing between new and old thrombus (Wu et al, 2020).Besides the use of D-A-D scaffolds, efforts have been underway to modify NIR-I emitting cyanine dyes. Reasonable modifications of cyanine dyes by replacement of the indolenine heterocycles with dimethyl-flavylium heterocycles (responsible for enhancing donor-acceptor strengths) could also help to shift the emission to the NIR-II window.…”

Section: (B))mentioning

confidence: 99%

Unlocking the power of optical imaging in the second biological window: Structuring near‐infrared II materials from organic molecules to nanoparticles

Dahal

Ray

Pan

2021

WIREs Nanomed Nanobiotechnol

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Biomedical imaging techniques play a crucial role in clinical diagnosis, surgical intervention, and prognosis. Fluorescence imaging in the second biological window (second near‐infrared [NIR‐II]; 1000–1700 nm) has attracted attention recently. NIR‐II fluorescence imaging offers unique advantages in terms of reduced photon scattering, deep tissue penetration, high sensitivity, and many others. A host of materials, including small organic molecules, single‐walled carbon nanotubes, polymeric and rare‐earth‐doped nanoparticles, have been explored as NIR‐II emitting fluorescent probes. Efficient and viable approaches to design and develop fluorescence probes with tunable photophysical properties without compromising other key features are of paramount importance. Various chemical strategies are explored to increase the quantum yield of these imaging agents without compromising their spatiotemporal resolution, specificity, and tissue penetration capabilities. This review summarizes the strategies implemented to design and synthesize NIR‐II emitting nanoparticles and small organic molecule‐based fluorescent probes for applications in the biomedical field. This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Implantable Materials and Surgical Technologies > Nanoscale Tools and Techniques in Surgery

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“…The targeted organic dyes could distinguish early thrombus and old thrombus. [ 43 ] The organic NIR‐II fluorophores have numerous advantages for in vivo and in vitro thrombosis or thrombus‐related diseases diagnosis. However, there is very limited literature available on thrombus‐induced diseases diagnosis via using NIR‐II fluorophores.…”

Section: Near‐infrared Bioimaging For Thrombosis Diagnosis and Therapymentioning

confidence: 99%

Near‐Infrared Fluorophores for Thrombosis Diagnosis and Therapy

Sun

Hettie

Zhu

2021

Advanced Therapeutics

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Thrombosis is an adverse physiological event wherein the resulting thrombus and thrombus‐induced diseases collectively result in high morbidity and mortality rates. Currently, nano‐medicines that incorporate fluorophores emitting in the near‐infrared‐I (NIR‐I, 700–900 nm) spectral region have been adopted to afford thrombosis theranostics. However, several unsolved problems such as limited penetration depth and image quality severely impede further applications of such nano‐medicine systems. Fortunately, the ability to incorporate fluorophores emitting in the NIR‐II (1000–1700 nm) window into nano‐medicine systems can unambiguously identify biological processes with high signal‐to‐noise, deep tissue penetration depth, and high image resolution. Considering the inherently favorable properties of NIR‐II fluorophores, it is believed that they have enormous potential to quickly become incorporated into nano‐medicine systems for thrombosis theranostics. In this review, i) the development of NIR fluorescence as an imaging modality and fluorescent agents is discussed; ii) the recent development of NIR‐I fluorophore‐based nano‐medicine systems for thrombosis theranostics is comprehensively summarized; iii) the state‐of‐the‐art NIR‐II fluorophores that are designed for the specific purpose of affording thrombotic diagnosis is highlighted; iv) possible forward avenues for the use of NIR‐II fluorophores toward thrombosis diagnosis and therapy are speculated; and v) the potential for their clinical translation is discussed.

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An RGD modified water-soluble fluorophore probe for in vivo NIR-II imaging of thrombosis

Abstract:
Synthesis of an organic near-infrared second-window fluorescent probe targeting in vivo and in vitro thrombi.

Cited by 21 publications

References 26 publications

Small Molecular NIR-II Fluorophores for Cancer Phototheranostics

Small Molecular NIR-II Fluorophores for Cancer Phototheranostics

Unlocking the power of optical imaging in the second biological window: Structuring near‐infrared II materials from organic molecules to nanoparticles

Near‐Infrared Fluorophores for Thrombosis Diagnosis and Therapy

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An RGD modified water-soluble fluorophore probe for in vivo NIR-II imaging of thrombosis

Abstract: Synthesis of an organic near-infrared second-window fluorescent probe targeting in vivo and in vitro thrombi.

Cited by 21 publications

References 26 publications

Small Molecular NIR-II Fluorophores for Cancer Phototheranostics

Small Molecular NIR-II Fluorophores for Cancer Phototheranostics

Unlocking the power of optical imaging in the second biological window: Structuring near‐infrared II materials from organic molecules to nanoparticles

Near‐Infrared Fluorophores for Thrombosis Diagnosis and Therapy

Contact Info

Product

Resources

About

Abstract:
Synthesis of an organic near-infrared second-window fluorescent probe targeting in vivo and in vitro thrombi.