An oxygen release system to augment cardiac progenitor cell survival and differentiation under hypoxic condition

Nano- and Microscale Delivery Systems for Cardiovascular Therapy

“…This suggested that [ 80 ] with permission from Elsevier biomaterials and their size alone could equally modulate tissue responses as exogenous growth factors. An impressive hydrogel-microsphere composite device was used to release and deliver small molecule oxygen (O 2 ) over extended time periods [ 83 ] in vitro. In this study, fi rst a hydrogen peroxide polyvinylpyrrolidone complex was encapsulated in core-shell PLGA microparticles (5 μm) to ensure slow release of hydrogen peroxide (H 2 O 2 ) from the core.…”

Hydrogels for cardiac tissue engineering

“…51,59 Such 3D biomimetic materials can be fabricated in the form of thin polymer films, 60 electrospun fibers, 61 porous scaffolds 62 and hydrogels. 63,64 The use of oxygen-releasing materials is particularly useful for providing sufficient amount of oxygen, especially during the early stages of in vitro cultures and in vivo implants. 56,65 Thus, such systems may be beneficial for regeneration of damaged or diseased cardiac tissues.…”

“…For example, in a recent study the potential of an oxygen-generating thermoresponsive hydrogel to improve the viability and differentiation of cardiac stem cells towards regeneration of myocardial infarcted tissues was investigated. 64 In this work, hydrogen peroxide and poly(2-vinlypyrridione) were encapsulated within poly(lactide-co-glycolide) microparticles. The oxygen-releasing microparticles were then incorporated into the thermoresponsive hydrogel precursor made of hydroxyethyl methacrylate-oligo(hydroxybutyrate), NIPAAm and AAc.…”

Controlled Oxygen Release from Pyridone Endoperoxides Promotes Cell Survival under Anoxic Conditions

“…5,[14][15][16] An intriguing strategy is the use of (biodegradable) polymers as scaffolds that slowly release oxygen in the graft. [17][18][19][20] The release must occur on a time-scale enabling the growth of a vascular network that can eventually support engineered tissue autonomously. From this perspective, the release of oxygen should occur over several days.…”