An ovine model of chronic stable heart failure

Devlin, Gerry; Matthews, Ken; McCracken, Geoff; Stuart, Selwyn; Jensen, Joergen L.; Conaglen, John V.; Bass, John L.

doi:10.1054/jcaf.2000.7279

Cited by 3 publications

(2 citation statements)

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“…Heart failure has been obtained through acute or chronic, complete or partial, surgical or interventional occlusion of the coronary arteries 9‐14 . There are pros and cons for each of these models as regards technical ease, cost, reliability, and outcome, but they are mostly relevant for the study of ischemic disease.…”

Section: Discussionmentioning

confidence: 99%

An Ovine Model of Chronic Heart Failure: Echocardiographic and Tissue Doppler Imaging Characterization

Borenstein¹,

Bruneval

Behr³

et al. 2006

J Cardiac Surgery

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Section: Discussionmentioning

confidence: 99%

An Ovine Model of Chronic Heart Failure: Echocardiographic and Tissue Doppler Imaging Characterization

Borenstein¹,

Bruneval

Behr³

et al. 2006

J Cardiac Surgery

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“…Heart failure was induced as previously described. 17 Briefly, the left anterior descending or left circumflex coronary artery was selectively catheterised via the carotid loop under fluoroscopic guidance and the artery occluded by infusion of 0.2 ml of a mixture comprising 200 mg sterile gel foam (Upjohn, Kalamazoo, MI, USA) suspended in 5 ml sterile saline, flushed through with 5 ml contrast medium (Omnipaque, Oslo, Norway). Duplocillin (5 ml) long-acting penicillin antibiotic (Intervet, Boxmeer, Holland) was given on completion of the procedure, and the animal returned to its pen for recovery.…”

Section: Introductionmentioning

confidence: 99%

Intrapericardial IGF-I Improves Cardiac Function in an Ovine Model of Chronic Heart Failure

Matthews

Devlin

Stuart

et al. 2005

Heart, Lung and Circulation

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Bovine Model of Doxorubicin‐Induced Cardiomyopathy

Bartoli

Brittian

Giridharan

et al. 2010

BioMed Research International

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Left ventricular assist devices (LVADs) constitute a recent advance in heart failure (HF) therapeutics. As the rigorous experimental assessment of LVADs in HF requires large animal models, our objective was to develop a bovine model of cardiomyopathy. Male calves (n = 8) were used. Four animals received 1.2 mg/kg intravenous doxorubicin weekly for seven weeks and four separate animals were studied as controls. Doxorubicin-treated animals were followed with weekly echocardiography. Target LV dysfunction was defined as an ejection fraction ≤35%. Sixty days after initiating doxorubicin, a terminal study was performed to determine hemodynamic, histological, biochemical, and molecular parameters. All four doxorubicin-treated animals exhibited significant (P < 0.05) contractile dysfunction, with target LV dysfunction achieved in three animals. Doxorubicin-treated hearts exhibited significantly reduced coronary blood flow and interstitial fibrosis and significantly increased apoptosis and myocyte size. Gene expression of atrial natriuretic factor increased more than 3-fold. Plasma norepinephrine and epinephrine levels were significantly increased early and late during the development of cardiomyopathy, respectively. We conclude that sequential administration of intravenous doxorubicin in calves induces a cardiomyopathy with many phenotypic hallmarks of the failing human heart. This clinically-relevant model may be useful for testing pathophysiologic responses to LVADs in the context of HF.

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An ovine model of chronic stable heart failure

Cited by 3 publications

References 0 publications

An Ovine Model of Chronic Heart Failure: Echocardiographic and Tissue Doppler Imaging Characterization

An Ovine Model of Chronic Heart Failure: Echocardiographic and Tissue Doppler Imaging Characterization

Intrapericardial IGF-I Improves Cardiac Function in an Ovine Model of Chronic Heart Failure

Bovine Model of Doxorubicin‐Induced Cardiomyopathy

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