An overview on therapeutic and medicinal potential of poly-hydroxy flavone viz. Heptamethoxyflavone, Kaempferitrin, Vitexin and Amentoflavone for management of Alzheimer’s and Parkinson’s diseases: a critical analysis on mechanistic insight

Varshney, Mansi; Bhavna, Kumar; Rana, Vijay Singh; Sethiya, Neeraj Kumar

doi:10.1080/10408398.2021.1980761

Cited by 7 publications

(6 citation statements)

References 217 publications

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“…For instance, besides being a nutritious edible oil, camellia oil can also be used as anti-rust oil and lubricant for industrial purposes; the pressed C. oleifera cake is both a natural fungicide and fertilizer, and the seed peel of C. oleifera is a raw material for extracting tannin extract [ 24 ]. Kaempferitrin is mainly distributed in the new leaf buds of Camellia sinensis, and it exhibits analgesic, anti-inflammatory, antidiabetic, antitumor, and chemotherapeutic effects, as well as activating insulin signaling [ 25 , 26 ]. Therefore, the examination of kaempferitrin in C. oleifera honey not only enables the authentication of C. oleifera honey, it also has realistic value for the evaluation of biological activity of C. oleifera honey.…”

Section: Resultsmentioning

confidence: 99%

Kaempferitrin: A Flavonoid Marker to Distinguish Camellia oleifera Honey

Huang

Zheng

et al. 2023

Nutrients

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C. oleifera is an economically important oilseed crop and medical plant. However, as a characteristic honey resource, the standard protocol used to identify the composition of C. oleifera honey has not been established yet. Previously, distinctive flavonoid has been shown as an effective marker to trace the botanical origin of honey. In this study, we examined the flavonoid types in C. oleifera honey and nine other monofloral honeys by using liquid chromatography tandem-mass spectrometry (LC-MS/MS) and compared the differences and identified eight distinct flavonoids in C. oleifera honey. Then, comparing the 8 flavonoids with the 14 flavonoids common to C. oleifera honey and nectar, two distinct flavonoids were identified in C. oleifera honey and nectar. Finally, we identified kaempferitrin as the distinct flavonoid marker in C. oleifera honey using the degree of influence of the partial least-squares discriminant analysis (PLS-DA) model on C. oleifera honey and ployfloral honey.

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Section: Resultsmentioning

confidence: 99%

Kaempferitrin: A Flavonoid Marker to Distinguish Camellia oleifera Honey

Huang

Zheng

et al. 2023

Nutrients

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“…Genistein, a natural isoflavone from soybeans, inhibits cancer cell growth by targeting protein tyrosine kinases and growth receptors like EGFR and ER. In neuroblastoma, studies have shown that genistein downregulates survival proteins (e.g., BCL2) and induces death factors and death domains (e.g., TNFR-1, TRADD, FADD) [50] . In our studies, we show that genistein serves as a lead second-stage chemoprevention agent by selectively targeting therapy pressure (radiotherapy)-driven response (unpublished data).…”

Section: Terpenementioning

confidence: 99%

Chemoprevention of neuroblastoma: progress and promise beyond uncertainties

2023

J Cancer Metastasis Treat

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Neuroblastoma is the most common extracranial solid tumor in children and comprises one-tenth of all childhood cancer deaths. The current clinical therapy for this deadly disease is multimodal, involving an induction phase with alternating regimens of high-dose chemotherapeutic drugs and load reduction surgery; a consolidation phase with more intensive chemotherapy, radiotherapy, and stem cell transplant; and a maintenance phase with immunotherapy and immune-activating cytokine treatment. Despite such intensive treatment, children with neuroblastoma have unacceptable life quality and survival, warranting preventive measures to regulate the cellular functions that orchestrate tumor progression, therapy resistance, metastasis, and tumor relapse/recurrence. Globally, active efforts are underway to identify novel chemopreventive agents, define their mechanism(s) of action, and assess their clinical benefit. Some chemoprevention strategies (e.g., retinoids, difluoromethylornithine) have already been adopted clinically as part of maintenance phase therapy. Several agents are in the pipeline, while many others are in preclinical characterization. Here we review the classes of chemopreventive agents investigated for neuroblastoma, including cellular events targeted, mode(s) of action, and the level of development. Our review: (i) highlights the pressing need for new and improved chemopreventive strategies for progressive neuroblastoma; (ii) lists the emerging classes of chemopreventive agents for neuroblastoma; and (iii) recognizes the relevance of targeting dynamically evolving hallmark functions of tumor evolution (e.g., survival, differentiation, lineage

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“…Previous reports suggest that amentoflavone is having neuroprotective effects and have shown promising results during CNS complications like AD, ischemic stroke, epilepsy, and Parkinson's disease (Varshney et al, 2021). Further, amentoflavone is known to reduce oxidative stress and neuroinflammation, which are crucial pathways for the development and progression of AD (Xiong et al, 2021).…”

Section: Molecular Dockingmentioning

confidence: 99%

Network Pharmacology and molecular docking approach to unveil the mechanism ofHypericum perforatumin the management of Alzheimer’s disorder

Dogra,

Choudhary,

Parashar

et al. 2023

Preprint

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The pathogenesis of Alzheimer disease (AD) is not fully understood which limits the availability of safer and more efficient therapeutic strategies for the management of AD. There has been growing interest in recent years in exploring the potential of herbal medicines as a source of safer and alternative therapeutic strategies for the management of AD. This study aims to discover the mechanism of Hypericum perforatum in the management of AD using network pharmacology and molecular docking approach. The results of network pharmacology suggest that 39 bioactive molecules of H. perforatum target 127 genes associated with AD, amongst which ATP-dependent translocase, acetylcholinesterase, amyloid-β precursor protein, β-secretase 1, carbonic anhydrase 2, dipeptidyl peptidase 4, epidermal growth factor receptor, tyrosine-protein phosphatase non-receptor type 1, α-synuclein, and vascular endothelial growth factor A seems to be the prominent target of these molecules. Further, the results of molecular docking predicted amentoflavone, I3,II8-biapigenin, rutin, miquelianin, quercetin, luteolin, and nicotiflorin as a promising modulator of target proteins which were determined from network pharmacology to be associated with AD. Our findings suggest that H. perforatum could be a safer and more promising alternative therapeutic strategy for the management of AD by targeting multiple pathways of AD pathogenesis.

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An overview on therapeutic and medicinal potential of poly-hydroxy flavone viz. Heptamethoxyflavone, Kaempferitrin, Vitexin and Amentoflavone for management of Alzheimer’s and Parkinson’s diseases: a critical analysis on mechanistic insight

Cited by 7 publications

References 217 publications

Kaempferitrin: A Flavonoid Marker to Distinguish Camellia oleifera Honey

Kaempferitrin: A Flavonoid Marker to Distinguish Camellia oleifera Honey

Chemoprevention of neuroblastoma: progress and promise beyond uncertainties

Network Pharmacology and molecular docking approach to unveil the mechanism ofHypericum perforatumin the management of Alzheimer’s disorder

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