An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda

Singh, Nitika; Bhalla, M.; Jager, Prashanti de; Gîlcă, Marilena

doi:10.4314/ajtcam.v8i5s.9

Cited by 352 publications

(300 citation statements)

References 16 publications

(8 reference statements)

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“…The potential additive effects of ETAS with spa therapy would also be of interest. Furthermore, compared to other current anti-stress options of herbs or -3 fatty acids (37,38), ETAS may offer a new, natural choice for people experiencing stress.…”

Section: Discussionmentioning

confidence: 99%

Effects of Enzyme-Treated Asparagus Extract on Heat Shock Protein 70, Stress Indices, and Sleep in Healthy Adult Men

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Goto

Takanari

et al. 2014

J Nutr Sci Vitaminol

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Section: Discussionmentioning

confidence: 99%

Effects of Enzyme-Treated Asparagus Extract on Heat Shock Protein 70, Stress Indices, and Sleep in Healthy Adult Men

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Goto

Takanari

et al. 2014

J Nutr Sci Vitaminol

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“…The Nagori is the supreme among all other varieties. Maximum benef it appears when fresh powder is used (Singh, 2011).…”

Section: Charak Samhitamentioning

confidence: 99%

An Update on Phytochemicals Analysis and Medicinal Prospects of Indian Herb Withania somnifera

Roy¹,

Saraf²

2017

ambi

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“…The roots and leaves of W. somnifera are commonly prescribed for tumors, inflammation, arthritis, asthma, and hypertension [9][10][11][12][13][14][15]. W. somnifera is the source of the largest and structurally most diversified set of withanolides, of which withaferin A (WA) is among the first of the group to be isolated and to show significant pharmacological properties, such as anti-tumor, anti-inflammatory, and immunomodulatory activity [9].…”

Section: Introductionmentioning

confidence: 99%

Nf-κb-Dependent Inhibition of HIV-1 Transcription by Withaferin A

Shi¹,

Wilhelm²,

Bell³

et al. 2017

HIV Curr Res

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Despite the remarkable progress made in suppressing HIV-1 infection, antiretroviral drugs are still often inaccessible in developing countries, and there is an urgent need for cheaper and alternative drugs. HIV-1 replication is triggered by the activation of the long terminal repeat (LTR) promoter, which contains two binding sites for the transcription factor nuclear factor κB (NF-κB). Withaferin A (WA), a steroidal lactone isolated from the Indian medicinal plant Withania somnifera, has been found to have significant pharmacological effects on the regulation of immune response. Recent studies have demonstrated that the anti-inflammatory properties of WA are mainly due to its inhibition of the NF-κB pathway. In the present study, we demonstrate that WA represses HIV-1 LTR transcription and viral replication through NF-κB inhibition.The human lymphocyte T cell line Jurkat E6.1 was treated with WA and infected with wild-type pseudotyped HIV-1 particles or mutant viruses containing inactive κB sites. Then, the effect of WA on HIV-1 replication was evaluated by the measurement of reporter activity. Electrophoretic mobility shift assays and Western blots analysis were also performed to study the impact of WA on NF-κB. We found that WA inhibited the transcription of wild-type pseudotyped viruses in single-round infection assays, whereas mutant viruses containing inactive κB sites showed a reduced response to WA. Moreover, we found that WA directly or indirectly inhibits NF-κB nuclear translocation, including RelA and p50 subunits. However, the degradation of inhibitory protein IκB-α was not prevented by WA. Taken together, our results suggest that WA inhibits HIV-1 transcription in human Jurkat E6.1 lymphocyte T cells through the NF-κB pathway.

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An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda

Cited by 352 publications

References 16 publications

Effects of Enzyme-Treated Asparagus Extract on Heat Shock Protein 70, Stress Indices, and Sleep in Healthy Adult Men

Effects of Enzyme-Treated Asparagus Extract on Heat Shock Protein 70, Stress Indices, and Sleep in Healthy Adult Men

An Update on Phytochemicals Analysis and Medicinal Prospects of Indian Herb Withania somnifera

Nf-κb-Dependent Inhibition of HIV-1 Transcription by Withaferin A

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