An Update on Phytochemicals Analysis and Medicinal Prospects of Indian Herb Withania somnifera

Roy, None Vishwaprakash; Saraf, Ashish

doi:10.21276/ambi.2017.04.2.rv01

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…From ancient times, Withania somnifera (WS), also known as ashwagandha, has been a significant plant in Ayurvedic and traditional medical systems [ 59 ]. The two main active components in ashwagandha are withaferin A and withanolide D, which have antioxidant, anti-inflammatory, immunomodulatory, anxiolytic, antidepressive, and neuroprotective properties [ 60 , 61 ]. Because of these alleged healing effects, WS is widely used in Ayurvedic medicine, and it has been explored as a treatment for a variety of disease conditions including anxiety, inflammation, PD, and cognitive impairment [ 62 ].…”

Section: Review Methodologymentioning

confidence: 99%

Therapeutic Implications of Some Natural Products for Neuroimmune Diseases: A Narrative of Clinical Studies Review

Wijeweera

Wijekoon

Gonawala

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Neuroimmune diseases are a group of disorders that occur due to the dysregulation of both the nervous and immune systems, and these illnesses impact tens of millions of people worldwide. However, patients who suffer from these debilitating conditions have very few FDA-approved treatment options. Neuroimmune crosstalk is important for controlling the immune system both centrally and peripherally to maintain tissue homeostasis. This review aims to provide readers with information on how natural products modulate neuroimmune crosstalk and the therapeutic implications of natural products, including curcumin, epigallocatechin-3-gallate (EGCG), ginkgo special extract, ashwagandha, Centella asiatica, Bacopa monnieri, ginseng, and cannabis to mitigate the progression of neuroimmune diseases, such as Alzheimer’s disease, multiple sclerosis, amyotrophic lateral sclerosis, Parkinson’s disease, depression, and anxiety disorders. The majority of the natural products based clinical studies mentioned in this study have yielded positive results. To achieve the expected results from natural products based clinical studies, researchers should focus on enhancing bioavailability and determining the synergistic mechanisms of herbal compounds and extracts, which will lead to the discovery of more effective phytomedicines while averting the probable negative effects of natural product extracts. Therefore, future studies developing nutraceuticals to mitigate neuroimmune diseases that incorporate phytochemicals to produce synergistic effects must analyse efficacy, bioavailability, gut-brain axis function safety, chemical modifications, and encapsulation with nanoparticles.

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Section: Review Methodologymentioning

confidence: 99%