An Overview of Various Biomimetic Scaffolds: Challenges and Applications in Tissue Engineering

Nigam, Rashi; Mahanta, Babita

doi:10.4172/2157-7552.1000137

Cited by 4 publications

(4 citation statements)

References 17 publications

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“…Even though various PEGDA-based scaffolds have been researched, however, none of them fulfils all the requirements for tissue engineering applications [10]. Some of these materials exhibit poor mechanical properties because of the weaknesses in their physical and mechanical stability [11], [12]. On the other hands, PEGDA hydrogel also lacks in cell adhesion, which it becomes a major limitation to be used as a tissue engineering scaffold [6].…”

Section: A Nurulhuda S Izman Nor Hasrul Akhmal Ngadimanmentioning

confidence: 99%

Fabrication PEGDA/ANFs Biomaterial as 3D Tissue Engineering Scaffold by DLP 3D Printing Tecshnology

Ahmad¹,

Sudin²,

Ngadiman³

2019

IJEAT

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Although traditional fabrication methods (electrospinning, solvent casting, freeze drying, etc...) can be used to produce scaffold, unfortunately, each of them has many limitations such as difficulty to control distinct 3D structure and porosity. These limitations can be easily overcome by unconventional techniques such as Fused Deposition Method (FDM), Selective Laser Sintering (SLS) and Stereolithography (SLA) to produce tissue engineering scaffold. Among the three, SLA offers the lowest cost, fastest printing speed and highest resolution. Digital light processing (DLP) 3D printing process is one of the SLA techniques which has been used a lot to fabricate tissue engineering scaffold based on Poly (ethylene glycol) diacrylate (PEGDA) material. However, there is no report published on the fabrication of tissue engineering scaffold based PEGDA filled with Aramid Nanofiber (ANFs). Hence, the feasible parameter setting for fabricating this material using DLP technique is currently unknown. The aim of this work is to establish the best feasible condition to fabricate PEGDA/ANFs 3D scaffold. ANFs was synthesized first from macro size Kevlar fiber prior to crosslinking with Diphenyl (2,4,6-trimethylbenzoyl) phosphine oxide (TPO) photoinitiator. The mixing ratio of PEGDA resin to ANFs was fixed to 9:1. The concentration of TPO was varied at 0.5, 1.0 and 1.7% wt. while the resin concentration was fixed at 30% during the mixing to produce three set of biomaterials. Calibration printing was conducted prior to actual printing with the purpose of eliminating unprintable TPO concentration. The final scaffold was printed using DLP machine (FEMTO…) at two different curing times i.e 70 and 80s to obtain a good shape and printable 3D structure. The synthesized ANFs showed that a single diameter in nano size at a range of 50 nm ~ 80 nm was able to produce. During calibration printing, it was found that 1.7%wt of TPO failed to produce a 3D profile shape. The final printing results of 0.5%wt and 1%wt of TPO were compared after being cured at 70s and 80s. It was observed that the printed 3D scaffold of 1%wt TPO at 70s curing time produces the most discernable shape of tensile specimen (ISO 37:2011) than the other three conditions. The findings from this study can be potentially used a guideline for developing a 3D structure of tissue engineering scaffold by using DLP 3D printing process.

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Section: A Nurulhuda S Izman Nor Hasrul Akhmal Ngadimanmentioning

confidence: 99%

Fabrication PEGDA/ANFs Biomaterial as 3D Tissue Engineering Scaffold by DLP 3D Printing Tecshnology

Ahmad¹,

Sudin²,

Ngadiman³

2019

IJEAT

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“…Polymer nanofibers possess distinctive properties that render them invaluable tools in tissue engineering applications. 8 Their high surface-to-volume ratio and microporous structure make them particularly well-suited for cell adhesion, migration, and proliferation. Numerous methods exist for polymer production, 9 with electrospinning standing out as the most popular technique for creating nanofibers, especially in tissue engineering applications.…”

Section: Introductionmentioning

confidence: 99%

“…Numerous methods exist for polymer production, 9 with electrospinning standing out as the most popular technique for creating nanofibers, especially in tissue engineering applications. [6][7][8][9] Polylactic acid (PLA), a synthetic polymer, has gained prominence in the production of tissue engineering scaffolds. PLA is known for its biocompatibility and biodegradability.…”

Section: Introductionmentioning

confidence: 99%

Potential of Collagen/PLA-based Nanofibrous Scaffold to Support PC12 Cells and Neural Repair

Aseer,

Taleb,

Arabpour

et al. 2024

J. Contemp. Med. Sci.

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Objective: This study attempts to modify Polylactic Acid (PLA) with the natural polymer Collagen (Coll), to develop materials such as an electrospun scaffold that have better mechanical stability and biocompatibility. Retinoic acid (RA), a bioactive material that promotes nerve growth, is to be added to the nanofiber scaffolds as part of this project. Methods: One of the most important methods we employed in this work to create nanofibrous scaffolds was electrospinning. Results: The synthesized nanofiber scaffold exhibited a diameter of 255±40 nm and a tensile strength of 175±10.4 N, providing sufficient support for native peripheral nerve repair. The inclusion of Coll enhanced the scaffold's hydrophilic behavior (contact angle: 56±4°), ensuring stability in aqueous solutions. In addition, cell adhesion and proliferation are demonstrated to be improved by PLA composite nanofibers based on Collagen, while PC12 cell adhesion and proliferation are further improved by RA. Conclusion: Based on their biodegradability, robust mechanical properties, and porous structure, these scaffolds are excellent choices for nerve tissue engineering, according to our findings. The significant increase in PC12 cells' adhesion and proliferation upon the addition of RA demonstrates the cells' potential for nerve repair.

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“…The principle of tissue engineering is that proper cells can be expanded in tissue culture and seeded into a scaffold. Scaffolds can be prepared from a specific building material with three dimensions that is similar to target tissue structurally and mechanically [6]. Because of the importance of designing scaffolds in tissue engineering close to target tissues properties, excellent research efforts have been directed to the progress of simulating and modeling approaches to design scaffolds in tissue engineering which is near the properties of target tissues.…”

Section: Introductionmentioning

confidence: 99%

Meso modeling of silk wire rope scaffolds in tissue engineering

Abdellahi

Naghashzargar

Semnani

2016

Journal of Industrial Textiles

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Finite element method can provide valuable results and information to evaluate and assess the mechanical behavior of tissue engineered scaffolds. In this investigation, a structurally and analytically based model is applied to analyze and to describe the mechanical properties of wire rope yarns as scaffold or other applications in textile engineering. In order to modeling the mechanical behavior of single yarn, non-linear hyperfoam model with three strain energy potential has been used. The results of finite element model are compared with an experimental approach and showed good agreement between software and experimental analysis with a maximum error at break of about 4.3%. As a result, validation of the finite element method is guaranteed for analysis of other structure of multi twisted yarn or wire ropes.

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An Overview of Various Biomimetic Scaffolds: Challenges and Applications in Tissue Engineering

Cited by 4 publications

References 17 publications

Fabrication PEGDA/ANFs Biomaterial as 3D Tissue Engineering Scaffold by DLP 3D Printing Tecshnology

Fabrication PEGDA/ANFs Biomaterial as 3D Tissue Engineering Scaffold by DLP 3D Printing Tecshnology

Potential of Collagen/PLA-based Nanofibrous Scaffold to Support PC12 Cells and Neural Repair

Meso modeling of silk wire rope scaffolds in tissue engineering

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