An Overview of Treatment Challenges and the role of Herbal Antioxidants in Diabetes Mellitus

Ravi, K. S.; Jose, Rosmi; Sk, Sumitha; Johny, Teena; Krishnaveni, K; R, Shanmuga Sundaram; R, Sambath Kumar

doi:10.5958/0974-360x.2017.00490.5

Cited by 8 publications

(1 citation statement)

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“…Nowadays, with the high impact advertisements on the targeted consumers and convincing real-case testimonies, health tonic for wellness among the Malay communities is becoming sensational selling item in the Malaysia's health product landscape. In addition, herbal remedies are preferred among consumers as these are believed to be effective but has mild adverse effects and more economic viable (Ravi et al 2017). Coupled with the high trending in the demand for natural based medicine, this botanical drink successfully drives the consumer believes that consumption of this drink can improve their health status as it claims high in antioxidants.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Anti-Diabetic Status of Popular Malay Health Tonic Consumed for Wellness: Help or Hype?

Zayapor¹,

Abdullah²,

Mustapha³

2020

JSM

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Contemporary Malay health tonics labeled as botanical drinks are advertised in the Malaysian market as effective therapeutic supplements toward improving consumer health. The therapeutic claims associated with high antioxidants are based on the herbal ingredients used, yet unproven by scientific evidence. Moreover, they are mostly sweetened with sugar, which may arise the potential of diabetic risk. Thus, a dire clarification on the potential antioxidant status and diabetic risk of these products is essential to nullify over claims. Eight commercial botanical drinks that serve as health tonics were selected based on their advertisement popularity and traditional medicine sellers' interview feedbacks. The selected tonics were mutually compared with a green tea (DGT01) as the benchmark for their total phenolic content (TPC); antioxidant activities [the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging inhibition capacities, IC 50 ; Ferric ion reducing antioxidant power (FRAP); and Oxygen radical absorbance capacity (ORAC)], anti-diabetic property through the α-glucosidase inhibition (AGI) and as well as the sugar content. The results were mapped for variations using Principal Component Analysis (PCA). Three out of 8 health tonics (NS12, SK53, and MU13) has approximately 3 to 4-fold, 1.1-fold and 2.5-fold higher in TPC, ORAC, and FRAP reducing capacities, respectively. Only NS12 and SK53 showed strong AGI (>80% inhibition). Three tonics, NS12, SK53, and HS06 exhibited precaution levels of sugar with more than 180 mg of total sugars per serving. From the PCA, DGT01 was dissociated from any tonic. NS12 and SK23 were closely related in terms of antioxidant and AGI activities. Although they showed promising therapeutic benefits due to high antioxidant activities and low diabetic risk, the tonics' efficacies and safety are still dubious shall be verified by reliable clinical trials. The selection of a health tonic shall not only be based on multi antioxidant-rich ingredients but low in sugar for a healthier choice.

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Section: Introductionmentioning

confidence: 99%

Antioxidant and Anti-Diabetic Status of Popular Malay Health Tonic Consumed for Wellness: Help or Hype?

Zayapor¹,

Abdullah²,

Mustapha³

2020

JSM

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Anti-diabetic potential of Indian Medicinal plants with Garcinia kola and Syzygium cumini

Sharmila

Priya.J

et al. 2021

RJPT

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Diabetes mellitus is a group of metabolic disease in which a person experiences high blood glucose levels either because the body produces inadequate insulin in the body. Though there are several treatment options available there are limitations such as high costs and side effects, weight gain etc. For this reason, the use of medicinal plants has increased to be used as an anti-diabetic agent with less side-effect and more efficient. In this regard, this study analyzed the anti-diabetic potential of Garcinia kola and Syzygium cumini using alpha amylase inhibition assay and glucose uptake by yeast cells. It was observed that Ethanol extract of Garcinia kola increased anti-diabetic potential compared to Syzygium cumini.

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Hypoglycemic, Hypolipidemic, Renal Protective and Antioxidant Activity of Annona muricata in Streptozotocin-Induced Diabetic Rats

Mohammed

Ramadhan

Shari

2021

RJPT

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Annona muricata, an herbal plant commonly used in traditional medicine to manage numerous diseases, diabetes as other diseases could be managed with herbal medicine. This study was designed to be investigated the antidiabetic, hypolipidemic, renal protective, and antioxidant effects of aqueous extracts of Annona muricata as used alone or combined with metformin in streptozotocin (STZ)-induced diabetic rats. Methods: the study was involved twenty adult Wister albino rats in four groups (five rats in each) and designated as groups, control group (1), and experimental groups (2, 3, 4). Diabetes was induced in experimental groups by 60 mg/kg intravenous streptozotocin injection. Group 2: serves as a diabetic control group, Group 3: diabetic rats treated with oral administration of 100 mg/kg of Annona muricata aqueous extract, Group 4: diabetic rats treated with combination (100 mg/kg aqueous extract of Annona muricata + 50 mg/kg metformin). The treatment continuous daily for 4 weeks to determine the levels of blood glucose and biochemical analysis. Result: aqueous extract of Annona muricata was reduced the serum glucose level effectively in streptozotocin-induced diabetic rats, by 48% and 55% after 28 consecutive days of treatment when used alone and with metformin, respectively. These compared to the preliminary values and the reduction was statistically significant compared to a diabetic control group. Daily oral administration of 100 mg/kg aqueous extract of Annona muricata for 4 weeks to streptozotocin-induced diabetic rats significantly reduced the level of total cholesterol, urea, creatinine, and MDA, whereas the reduction was non-significant in triglyceride and VLDL-cholesterol levels as compared to the non-treated diabetic group. However, the reduction is more significant in streptozotocin-induced diabetes rats that were treated with a combination of Annona muricata and metformin when compared to the diabetic control group. Conclusion: Aqueous extracts of Annona muricata have anti-diabetic action through their hypoglycemic, hypolipidemic, renal protective, and antioxidant effects in streptozotocin-induced diabetic rats. Thus, can be used alone or with anti-hyperglycemic drugs as metformin in the management of DM. The combination is preferred in severe hyperglycemic cases with more hypoglycemic effect requirements.

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An Overview of Treatment Challenges and the role of Herbal Antioxidants in Diabetes Mellitus

Cited by 8 publications

References 0 publications

Antioxidant and Anti-Diabetic Status of Popular Malay Health Tonic Consumed for Wellness: Help or Hype?

Antioxidant and Anti-Diabetic Status of Popular Malay Health Tonic Consumed for Wellness: Help or Hype?

Anti-diabetic potential of Indian Medicinal plants with Garcinia kola and Syzygium cumini

Hypoglycemic, Hypolipidemic, Renal Protective and Antioxidant Activity of Annona muricata in Streptozotocin-Induced Diabetic Rats

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