Anti-diabetic potential of Indian Medicinal plants with Garcinia kola and Syzygium cumini

Sharmila, K J; L, Kanimozhi.; Priya.J, Shanmuga; Vidhya, G V; R, Caroline Jeba; Kowsalya, R.

doi:10.52711/0974-360x.2021.00990

RJPT

2021

DOI: 10.52711/0974-360x.2021.00990

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Anti-diabetic potential of Indian Medicinal plants with Garcinia kola and Syzygium cumini

K J Sharmila

Kanimozhi. L

Shanmuga Priya.J

et al.

Abstract: Diabetes mellitus is a group of metabolic disease in which a person experiences high blood glucose levels either because the body produces inadequate insulin in the body. Though there are several treatment options available there are limitations such as high costs and side effects, weight gain etc. For this reason, the use of medicinal plants has increased to be used as an anti-diabetic agent with less side-effect and more efficient. In this regard, this study analyzed the anti-diabetic potential of Garcinia k… Show more

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A Synthesis and Review of Ethnomedicinal Uses, Phytochemistry and Biological Activities of Paropsia brazzeana Baill. (Passifloraceae)

Maroyi

2022

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Paropsia brazzeana is a shrub used traditionally to treat various human diseases and ailments. Paropsia brazzeana naturally occurs from Cameroon and the Central African Republic south to Angola, the Caprivi strip of Namibia, Botswana and Zimbabwe. The aim of this review was to provide an overview and critically analyze the ethnomedical uses, phytochemistry and biological activities of P. brazzeana. The results of the current study are based on literature survey conducted using various search engines such as Elsevier, Pubmed, Google scholar, Springer, Science Direct, Taylor and Francis, and pre-electronic sources such as books, book chapters, scientific journals and other grey literature. The fruit, leaf, leaf sap, root, root bark and stem bark decoction or infusion of P. brazzeana are mainly used as charm and rituals, and traditional medicine for gastro-intestinal infections, gonorrhoea, malaria and toothache. Chemical constituents identified from P. brazzeana include alkaloids, hydrocyanic acid, polyphenol, proanthocyanidins, reducing sugars, saponins, steroids, tannins and terpenes. The species possesses biological activities such as antiamoebic, antibacterial and antispasmodic activities. Paropsia brazzeana is a valuable medicinal plant species and future research should focus on animal experiments aimed at assessing toxicity and clinical efficacy of species extracts.

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A Synthesis and Review of Ethnomedicinal Uses, Phytochemistry and Biological Activities of Paropsia brazzeana Baill. (Passifloraceae)

Maroyi

2022

RJPT

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In-silico Screening of Potential Phytochemicals against Extracellular Adherence (Eap) Protein of Staphylococcus aureus from Indian Medicinal Plants

Zeenat,

Prajapati,

Sangeet

et al. 2023

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Background: Staphylococcus aureus is a threat to human health, it colonizes one-third of the human population via skin or nose and deeper intrusions into tissues have catastrophic consequences. The bacterium secretes virulence proteins like CHIP and SCIN and extracellular adhesins like extracellular adherence (Eap) proteins. Eap and its functionally orphan homologs, EapH1 and EapH2; are a class of secreted proteins that inhibit neutrophil serine proteases such as neutrophil elastase (HNE) that is linked to tissue degradation in a variety of disease conditions including inflammatory disorders. Commercial drugs used against S.aureus such as Nafcillin, Pefloxacin, etc. have been known to have negative effects and are not recommended for children, the elderly, or pregnant women. Objective: The current research focuses on discovering phytochemicals found in Indian medicinal herbs that have been used as spices for ages and are already beneficial against a variety of illnesses and ailments to be used against Eap proteins. Method: Molecular docking;absorption, distribution, metabolism, excretion, toxicity (ADMET) analysis and Simulation were performed to see if these phytochemicals interact with the active site residues of Eap proteins and function as competitive inhibitors of NE and to know their drug like properties and gather information about the system dynamics. 19 phytochemicals were selected from receptor-ligand docking. The selected molecules were pharmacologically tested through Lipinski’s analysis; to know their ability for being formulated into drugs. ADMET analysis was carried out to define the biological characteristic of phytochemicals inside the living body. The phytochemicals with the best docking score and drug likeliness were analysed by Molecular Simulation to observe the fluctuation of participating and interacting amino acids with Eaph1 and Eaph2 respectively. Result: Among the nineteen phytochemicals that were chosen for docking only the best eleven interactions were chosen for ADMET analysis. The top hit phytochemicals for Eaph1 and Eaph2 were Curcumin and Eugenol respectively, which was well demonstrated by Molecular dynamic simulation. Conclusion: The present study has established the hypothesis that phytochemicals have a scope to replace commercial drugs against the Eap virulence system of Staphylococcus aureus

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Anti-diabetic potential of Indian Medicinal plants with Garcinia kola and Syzygium cumini

Cited by 2 publications

References 12 publications

A Synthesis and Review of Ethnomedicinal Uses, Phytochemistry and Biological Activities of Paropsia brazzeana Baill. (Passifloraceae)

A Synthesis and Review of Ethnomedicinal Uses, Phytochemistry and Biological Activities of Paropsia brazzeana Baill. (Passifloraceae)

In-silico Screening of Potential Phytochemicals against Extracellular Adherence (Eap) Protein of Staphylococcus aureus from Indian Medicinal Plants

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