An overview of the safety of sucralose

Grotz, V. Lee; Munro, I.C.

doi:10.1016/j.yrtph.2009.05.011

Cited by 118 publications

(94 citation statements)

References 30 publications

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“…In the year 2000, the National Institute of Health (NIH) removed saccharine from the list of a potential carcinogens (15) and all products containing saccharine are no longer have to carry the warning label.…”

Section: Benzoic Sulfilminementioning

confidence: 99%

High intensity sweeteners chemicals structure, properties and applications

Ibrahim

2015

Natural Science and Discovery

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High Intense-sweeteners (HIS) are commonly used as a sugar substitutes or sugar alternatives and provide sweet without calories. HIS are in high demands due to its multiple advantages including assisting people in losing weight or avoiding obesity and assisting diabetics to control their blood sugar level. The first known intensesweetener is Saccharine that was discovered in the year 1878. Since then scientists discovered several other intensive sweeteners that are sweater than sucrose with zero calorie. Some discovered sweeteners are Plants extract (Stevoil glycosides, and Mogrosides), semi-synthetic peptides (Aspartame, Neotame, and sucralose), and synthetic chemicals. (Saccharine, Acesulfame-K, and Cyclamate).These High intensive sweeteners have been approved as safe for applications (1) in foods, beverages, dietary supplements, and pharmaceuticals products by Food and Drug administration (FDA) (2) in United States and by other similar agencies in other countries (3). The levels of these non-nutritive high intensive sweeteners used in foods, beverages, dietary supplements, and pharmaceutical products are based on the approved daily intake (ADI) by FDA and by other safety authorities worldwide. This ADI level is 100 fold lower than the safe dose demonstrated in laboratory studies. It is estimated that the global demand of HIS is exceeding 9.0 billion dollars and growing. The only HIS that is declining in global market is the old discovered sweetener Saccharine

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Section: Benzoic Sulfilminementioning

confidence: 99%

High intensity sweeteners chemicals structure, properties and applications

Ibrahim

2015

Natural Science and Discovery

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“…Sucralose has qualities that are interesting not only for the consumers but also to the food and beverage industry. Some of these qualities are: it is very stable at high temperatures and low pH; it does not leave an aftertaste like many others sweeteners do; it cannot be hydrolyzed during the digestion and metabolic processes since the carbon-chloro linkage is very stable; it is fairly soluble in water and it presents high stability both in crystalline and solution forms (Grotz and Munro, 2009;Rodero et al, 2009). Fructose is found naturally in fruits and honey, but may also be obtained through industrial process for the inversion of sucrose.…”

Section: Introductionmentioning

confidence: 99%

Influence of sweeteners in the biodistribution of radiopharmaceutical and laboratory tests in rats

Queiroz¹,

Barbosa²,

Holanda³

et al. 2016

Afr. J. Biotechnol.

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This study aimed to evaluate the effect of supplementation of sucralose and fructose on the metabolism of adolescent rats. Eighteen male Wistar rats were divided into 3 groups: control group (GC), fructose group (GF) treated with 50 mg/kg of fructose, and sucralose group (GS) receiving 50 mg/kg of sucralose for 24 days. The weight and feed intake were measured weekly. At the end of the experiment, some biochemical parameters, histopathology of the liver and biodistribution of the radiotracer 99m Tc-sodium phytate in liver and blood were analyzed. The GF showed higher body weight only in the first week compared with GS and GC (p<0.05). Histopathology and % ATI/g radiotracer 99m Tc-sodium phytate in liver and blood were not different between the groups. The GF showed higher values of aspartate aminotransferase activity, bilirubin, alkaline phosphatase activity and gamma glutamyl transferase activity, compared with the other groups (GC and GS) (p<0.05). Activity of alanine aminotransferase and albumin level of GF were higher than GS (p<0.05). For other parameters, no statistical difference was observed. It was concluded that the use of fructose during the experiment was able to alter hepatic enzymes, but on the other hands, the use of sucralose caused no change.

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“…Although there have been varioustoxicity tests and studies thatensure the safety of sucralose in food and beverages [3]- [5], there have been few studies of its fate and behavior after it's been excreted by the human body. Sucralose has beendetected in municipal wastewater and surface water in Europe.…”

Section: Introductionmentioning

confidence: 99%

Degradation of Sucralose by Peroxidation Assisted with Ultraviolet Radiation and Photo-Fenton

Ferreira¹,

Maniero²,

Guimarães³

2015

IJET

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Abstract-Substances discharged intobodies of water must be studied due to possible risk of contamination and consequent damage to nature and human health.Sucralose is an artificial sweetener widely used to produce diet food and beverage. Most of this substance is expelled intact fromthe human body; therefore, its concentration in rivers and wastewaters is increasing worldwide. In this work, sucralose degradation was performed using advanced oxidation processes (

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An overview of the safety of sucralose

Cited by 118 publications

References 30 publications

High intensity sweeteners chemicals structure, properties and applications

High intensity sweeteners chemicals structure, properties and applications

Influence of sweeteners in the biodistribution of radiopharmaceutical and laboratory tests in rats

Degradation of Sucralose by Peroxidation Assisted with Ultraviolet Radiation and Photo-Fenton

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