“…In another study, high serum levels of IL-6 were associated with the tumor stage, tumor size, tumor metastasis, and survival of patients [ 42 ]. Increased serum levels of IL-8 because of polymorphisms in the IL-8/CXCR2 genes were associated with disease progression, disease recurrence, and drug resistance [ 43 , 44 , 45 , 46 ]. Furthermore, patients with COPD with frequent exacerbations were reported to have high levels of inflammatory markers, such as CRP [ 47 ], fibrinogen [ 47 ], IL-6 [ 48 ], soluble tumor necrosis factor-α receptors [ 37 , 49 , 50 ], and osteoprotegrin [ 37 ], which have been shown to be associated with the survival of patients with colorectal cancer [ 39 , 40 , 41 , 42 , 51 , 52 , 53 , 54 ].…”