2020
DOI: 10.1016/j.cyto.2020.155205
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An overview of the role of interleukin-8 in colorectal cancer

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Cited by 28 publications
(29 citation statements)
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“…IL-8 is another potential therapeutic target, as the expression of IL-8 in the tumor microenvironment induces colon cancer growth and metastasis [ 108 ]. However, to date, the IL-8 inhibitors have also not yet been proven effective enough on their own [ 109 , 110 , 111 ].…”
Section: Caf–tumor Communicationmentioning
confidence: 99%
“…IL-8 is another potential therapeutic target, as the expression of IL-8 in the tumor microenvironment induces colon cancer growth and metastasis [ 108 ]. However, to date, the IL-8 inhibitors have also not yet been proven effective enough on their own [ 109 , 110 , 111 ].…”
Section: Caf–tumor Communicationmentioning
confidence: 99%
“…The role of tumor necrosis factor-α is in the activation of immune cells and subsequent carcinogenic activity by ERK, NF-kB and PI3K-AKT pathways resulting in increased levels of β-catenin [ 5 , 19 , 20 ]. Via NF-kB, TNFα reduces MUC2 activity with the effect of reducing the production of the mucin layer, which exposes the underlying cell to damage [ 21 ].…”
Section: Resultsmentioning
confidence: 99%
“…IL-8 is responsible for the proliferation and survival of cancer cells, angiogenesis and tumor infiltration, regulating the actions of macrophages, neutrophils, endothelial cells, TRegs and cancer cells. IL-8 acts through AKT, MAPK, STAT-3 intracellular pathways, ERK extracellular pathway and SNAIL, which is a signal that leads to conversion from epithelial to mesenchymal cells necessary for tumor progression [ 10 , 20 ]. Moreover, IL-8 upregulates serine-proteases of ECM, which in turn, are involved in the disruption of the integrity barrier [ 10 ].…”
Section: Resultsmentioning
confidence: 99%
“…In another study, high serum levels of IL-6 were associated with the tumor stage, tumor size, tumor metastasis, and survival of patients [ 42 ]. Increased serum levels of IL-8 because of polymorphisms in the IL-8/CXCR2 genes were associated with disease progression, disease recurrence, and drug resistance [ 43 , 44 , 45 , 46 ]. Furthermore, patients with COPD with frequent exacerbations were reported to have high levels of inflammatory markers, such as CRP [ 47 ], fibrinogen [ 47 ], IL-6 [ 48 ], soluble tumor necrosis factor-α receptors [ 37 , 49 , 50 ], and osteoprotegrin [ 37 ], which have been shown to be associated with the survival of patients with colorectal cancer [ 39 , 40 , 41 , 42 , 51 , 52 , 53 , 54 ].…”
Section: Discussionmentioning
confidence: 99%