An Overview of Meningiomas

Buerki, Robin; Horbinski, Craig; Kruser, Tim J.; Horowitz, Peleg; James, C. David; Lukas, Rimas V.

doi:10.2217/fon-2018-0006

Cited by 375 publications

(441 citation statements)

References 89 publications

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“…Meningiomas are slow-growing, well-circumscribed tumors arising from the arachnoid cap cells of the dura mater. Most meningiomas are benign, which corresponds to the WHO grade I, and AM (WHO grade II) are reported in 5-7% of all cases (3,4). In the present study, we first compared some clinical characteristics between AM and BM patients.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, the overall recurrence rate was 40% within a median of 34 months; 60% of AM patients received complete resection and the recurrence rate was 11.1% in patients receiving complete resection. Currently, the recurrence rate varies among available studies, which might be partially related to the definition of recurrence, surgical methods and therapeutic strategies (3).…”

Section: Discussionmentioning

confidence: 99%

“…Meningiomas, a tumor of meningothelial cell origin, are the second most common intracranial tumor and account for about 24-30% of intracranial tumors (1)(2)(3). According to the World Health Organization classification system, meningiomas are classified into grade I (typical), grade II (atypical), and grade III (anaplastic) tumors.…”

Section: Introductionmentioning

confidence: 99%

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Factors Related to the Post-operative Recurrence of Atypical Meningiomas

Tang

Yang

et al. 2020

Front. Oncol.

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Aim: This study aimed to investigate the relationship between clinicopathological characteristics of atypical meningiomas (AM) and its post-operative recurrence. Materials and Methods:The clinicopathological characteristics and findings from follow up were retrospectively reviewed and compared between AM and benign meningioma (BM) patients. Univariate and multivariate analyses were employed to identify the factors related to the post-operative recurrence of AM.Results: More BM patients were females and received complete resection; the recurrence rate was significantly lower in BM patients as compared to AM patients. The progesterone receptor (PR), E-cadherin protein (E-Ca) and β-catenin positive rates and Ki67 labeling index were significantly different between two groups. Univariate analysis showed the age, tumor size, tumor invasiveness, E-Ca expression, and extent of resection were related to the post-operative recurrence of AM. However, multivariate analysis showed only the extent of resection and tumor invasiveness were the independent factors associated with the post-operative recurrence of AM. Conclusions:The extent of resection and tumor invasiveness are related to the postoperative recurrence of AM. To improve the surgical procedures to maximize the tumor resection is important to improve the prognosis of AM patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Factors Related to the Post-operative Recurrence of Atypical Meningiomas

Tang

Yang

et al. 2020

Front. Oncol.

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“…The first genetic alteration observed in meningiomas was monosomy of chromosome 22 or deletion of 22q; the key gene involved, NF2 is the gene involved in the genesis of the type-2 neurofibromatosis, and is located on 22q12, encoding the tumor suppressor merlin [97,98]. Interestingly, genetic abnormalities in meningiomas are different in relation to the location and the type of the lesion: in fact, SMO and AKT1-MTOR mutations are quite common in non-NF2, genomically stable meningiomas of the skull base.…”

Section: Meningiomamentioning

confidence: 99%

“…On the other hand, meningiomas with NF2 inactivation are genomically less stable and localize to the brain hemispheres. Moreover, mutations of NF2 are most frequent in fibroblastic/transitional meningiomas, KLF4 and TRAF7 in secretory meningiomas, and AKT1 mutations in grade I meningothelial meningiomas of the skull base and spine [97]. 80% of patients with recurrent chordoid meningiomas have complete deletions on all four chromosomal loci 22q, 18p, 14q, and 1p [99,100].…”

Section: Meningiomamentioning

confidence: 99%

Innate and Adaptive Immunity Linked to Recognition of Antigens Shared by Neural Crest-Derived Tumors

Donato

Presta

Arcidiacono

et al. 2020

Cancers

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In the adult, many embryologic processes can be co-opted by during cancer progression. The mechanisms of divisions, migration, and the ability to escape immunity recognition linked to specific embryo antigens are also expressed by malignant cells. In particular, cells derived from neural crests (NC) contribute to the development of multiple cell types including melanocytes, craniofacial cartilage, glia, neurons, peripheral and enteric nervous systems, and the adrenal medulla. This plastic performance is due to an accurate program of gene expression orchestrated with cellular/extracellular signals finalized to regulate long-distance migration, proliferation, differentiation, apoptosis, and survival. During neurulation, prior to initiating their migration, NC cells must undergo an epithelial–mesenchymal transition (EMT) in which they alter their actin cytoskeleton, lose their cell–cell junctions, apicobasal polarity, and acquire a motile phenotype. Similarly, during the development of the tumors derived from neural crests, comprising a heterogeneous group of neoplasms (Neural crest-derived tumors (NCDTs)), a group of genes responsible for the EMT pathway is activated. Here, retracing the molecular pathways performed by pluripotent cells at the boundary between neural and non-neural ectoderm in relation to the natural history of NCDT, points of contact or interposition are highlighted to better explain the intricate interplay between cancer cells and the innate and adaptive immune response.

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A Case of Persistent Frontal Swelling

Clifton

Abraham

Ray

2020

JAMA Otolaryngol Head Neck Surg

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An 85-year-old woman with a history of arthritis, hypercholesterolemia, hypertension, and glaucoma presented to the clinic for evaluation of chronic sinusitis. Symptoms included a several-year history of frontal pain, pressure, clear nasal discharge, and progressive nontender facial swelling above her glabella. She denied nasal disturbance, prior sinus surgery, asthma, or acetylsalicylic acid (aspirin) sensitivity. Symptoms were refractory to treatment with several rounds of oral antibiotics and oral steroids. Physical examination findings revealed symmetric facial movement with prominent glabellar swelling and soft tissue thickening. Nasal endoscopy findings revealed a soft tissue mass anterior to the axilla of the middle turbinates bilaterally, with normal-appearing mucosa overlying. Computed tomography and magnetic resonance imaging (MRI) scans were obtained for further evaluation (Figure , A). Recommendations were made to proceed to the operating room for biopsy of the nasal mass. Pathology results revealed uniform, epithelioid cells arranged in a whorled, lobulated growth pattern without atypia, necrosis, increased cellularity, or diffuse growth pattern (Figure, B and C).

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An Overview of Meningiomas

Cited by 375 publications

References 89 publications

Factors Related to the Post-operative Recurrence of Atypical Meningiomas

Factors Related to the Post-operative Recurrence of Atypical Meningiomas

Innate and Adaptive Immunity Linked to Recognition of Antigens Shared by Neural Crest-Derived Tumors

A Case of Persistent Frontal Swelling

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