Factors Related to the Post-operative Recurrence of Atypical Meningiomas

Wu, Ye; Tang, Dingzhong; Yang, Xiaosheng; Zhan, Renya; Li, Yi

doi:10.3389/fonc.2020.00503

Cited by 6 publications

(10 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Surgical removal of HGM is challenging, and it is not always completely successful because of the absence of clear cleavage planes between the tumor and surrounding vessels, brain parenchyma, or neurological structures, which could be caused by scars and/or irradiated tissue. This scenario is more common in patients who are undergoing repeat surgeries and in older patients who also have a higher risk of post-operative neurological deficits [23,24]. However, surgery remains the cornerstone of HGM patient management.…”

Section: Discussionmentioning

confidence: 99%

“…Research on the prognostic characteristics of recurrent HGMs is still ongoing, but many factors are already integral to the standard decision-making and risk-benefit analysis that was conducted at the time of each recurrence. The most important among them are patient-related factors, such as sex and age of tumor onset, and tumor-related factors, such as size, edema, location, and other features that have a direct impact on the extent of tumor resection [23].…”

Section: Discussionmentioning

confidence: 99%

“…Whenever tumor location is favorable, it is crucial that the first approach should comprise the most radical resection possible, including the excision of 2 cm of dural margin and all hyperostotic bone (to reach the lowest Simpson grade possible) [23]. HGMs also require close clinico-radiological follow-up to assess the likelihood of and time to recurrence, especially in patients who were identified as being at a higher risk.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Long term follow up in 183 high grade meningioma: A single institutional experience

Simonetti

Silvani

Tramacere

et al. 2021

Clinical Neurology and Neurosurgery

View full text Add to dashboard Cite

Introduction: Meningiomas are usually considered benign lesions, however a proportion of them shows a more aggressive behavior, defined high-grade meningiomas (HGM). Effective medical treatments are lacking, especially at the time of recurrence. Methods: Through a retrospective analysis, we examined epidemiological, diagnostic, therapeutic, recurrence information and survival data of HGM treated at our institution between 2010 and 2018. Results: 183 patients (105 females and 78 males), with median age of 58 years (25-88), were included; 168 were atypical, 12 anaplastic, 3 rhabdoid. Overall, m-PFS was 4.2 years, and m-OS was 10.3 years. Gross-total resection had a 5-year survival rate of 95% compared with subtotal/partial resection (86% and 67%) (p = 0.002). Higher expression of Ki-67/MIB-1 seems associated with higher risk of death (HR:1.06 with 95% CI, 1.00-1.12, p = 0.03). No statistically significant differences were seen in survival between the group managed with a wait-andsee strategy vs the group treated with RT while a difference on PFS was seen (4.1 years vs 5.2 years p = 0.03). After second recurrence, the most employed treatments were systemic therapies with a very limited effect on disease control. Conclusions: Data confirmed the aggressive behavior of HGM. The extent of resection seems to correlate with a favorable outcome regardless histological subtypes. The role of RT remains controversial, with no statistically significant impact on OS but a possible role on PFS. Recurrent HGM remains the real challenge, to date no chemotherapies are able to achieve disease control. Future research should focus on biological/molecular predictors in order to achieve a patient-tailored treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Long term follow up in 183 high grade meningioma: A single institutional experience

Simonetti

Silvani

Tramacere

et al. 2021

Clinical Neurology and Neurosurgery

View full text Add to dashboard Cite

show abstract

“…Meningiomas are the most common primary intracranial tumors and arise from the arachnoid cap cells of the dura mater (16).…”

Section: Discussionmentioning

confidence: 99%

A Clinical Prognostic Model Based on Preoperative Hematological and Clinical Parameters Predicts the Progression of Primary WHO Grade II Meningioma

et al. 2021

View full text Add to dashboard Cite

PurposeThe purpose was to explore the correlation between hematological parameters and the progression of WHO grade II meningioma, and establish a clinical prognostic model based on hematological parameters and clinical prognostic factors to predict the progression-free survival (PFS) of patients.MethodsA total of 274 patients with WHO grade II meningiomas were included. Patients were randomly divided into a training cohort (192, 70%) and a test cohort (82, 30%). In the training cohort, the least absolute shrinkage and selection operator Cox regression analysis were used to screen for hematological parameters with prognostic value, and the hematological risk model (HRM) was constructed based on these parameters; univariate and multivariate Cox regression analyses were utilized to screen for clinical prognostic factors, and a clinical prognostic model was constructed based on clinical prognostic factors and HRM. The prognostic stability and accuracy of the HRM and clinical prognostic model were verified in the test cohort. Subgroup analysis was performed according to the patients’ different clinical characteristics.ResultsPreoperative neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, platelet-to-lymphocyte ratio, albumin-to-globulin ratio, D-dimer, fibrinogen, and lactate dehydrogenase were associated with the PFS of patients. The areas under curve of the HRM were 0.773 (95% confidence interval [CI] 0.707–0.839) and 0.745 (95% CI 0.637–0.852) in the training cohort and test cohort, respectively. The progression risk was higher in the high-risk group than that in the low-risk group categorized by the optimal cutoff value (2.05) of hematological risk scores. The HRM, age, tumor location, tumor size, peritumoral edema, extent of resection, Ki-67 index, and postoperative radiotherapy were the prognostic factors for the progression of meningiomas. The corrected C-index of the clinical prognosis model was 0.79 in the training cohort. Clinical decision analysis showed that the clinical prognostic model could be used to obtain favorable clinical benefits. In the subgroup analysis, the HRM displayed excellent prognostic stability and general applicability in different subgroups.ConclusionsPreoperative hematological parameters are associated with the postoperative progression of WHO grade II meningiomas. The clinical prognosis model constructed based on hematological parameters and clinical prognostic factors has favorable predictive accuracy and clinical benefits.

show abstract

“…Pathological markers such as E-Ca, Ki67, and β-catenin are thought to be related to recurrence. 21 Proliferation parameters such as MIB-1 LI have also been proposed to predict the recurrence of meningioma. [22][23][24][25] Ros-Sanjuan et al advocated that total resection was the only significant factor associated with recurrence, 26 and furthermore, Simpson proved that the degree of resection grading system he proposed was related to tumor recurrence.…”

Section: Treatment and Prognosismentioning

confidence: 99%

Lateral Ventricular Meningiomas: Clinical Features, Radiological Findings and Long-Term Outcomes

Teng

Yan

et al. 2021

CMAR

View full text Add to dashboard Cite

Purpose Lateral ventricle meningioma (LVM) is a rare type of intracranial meningioma, which has been rarely studied. It has different clinical features, imaging features, and long-term results from other locations. This study investigated the epidemiology, clinical characteristics and prognosis of LVM and comprehensively describes its characteristics. Methods This article analyzes the LVMs that were diagnosed pathologically in West China hospital between January 1, 2009 and July 1 2020. Demographic information, imaging characteristics and prognostic factors are discussed. Data analysis was performed using SPSS 23.0 and R version 3.5.3. Results We collected 7202 meningiomas and 195 LVMs (136 females; median age, 46 years; range, 5–81 years) were included in this study. Gross total resection was completed in 189 patients. The OS rate was 93.8%, and the recurrence rate was 5.2%. Multivariate regression analysis showed that sex (P = 0.01) and tumor size (P = 0.018) were related to WHO grade. Postoperative KPS (P = 0.003) was associated with OS. WHO grade (P = 0.025), extent of tumor resection (P < 0.001), and hospital day (P=0.028) were associated with recurrence. Conclusion LVMs require long-term follow-up, individualized treatment, and follow-up strategies to be formulated according to the relevant risk factors.

show abstract

Factors Related to the Post-operative Recurrence of Atypical Meningiomas

Cited by 6 publications

References 26 publications

Long term follow up in 183 high grade meningioma: A single institutional experience

Long term follow up in 183 high grade meningioma: A single institutional experience

A Clinical Prognostic Model Based on Preoperative Hematological and Clinical Parameters Predicts the Progression of Primary WHO Grade II Meningioma

Lateral Ventricular Meningiomas: Clinical Features, Radiological Findings and Long-Term Outcomes

Contact Info

Product

Resources

About