An Overview of Green Synthesis and Potential Pharmaceutical Applications of Nanoparticles as Targeted Drug Delivery System in Biomedicines

Abstract

Nanotechnology-based nanomedicine offers several benefits over conventional forms of therapeutic agents. Moreover, nanomedicine has become a potential candidate for targeting therapeutic agents at specific sites. However, nanomedicine prepared by synthetic methods may produce unwanted toxic effects. Due to their nanosize range, nanoparticles can easily reach the reticuloendothelial system and may produce unwanted systemic effects. The nanoparticles produced by the green chemistry approach would enhance the safety profile by avoiding synthetic agents and solvents in its preparations. This review encompasses toxicity consideration of nanoparticles, green synthesis techniques of nanoparticle preparation, biomedical application of nanoparticles, and future prospects.

Molecular Docking Studies of Rifampicin – rpoB complex: Repurposing Drug Design Implications for against Plasmodium falciparum Malaria through a Computational Approach

“…Genetic mutations in the βsubunit of the DNAdirected RNA polymerase (rpoB) are reported to be a major reason of RIF resistance [25][26][27]. The mechanisms and structural basis of resistance to commonly used malaria drugs and these resistant mutations are insufficiently understood.…”