An overview of current COVID-19 clinical trials and ethical considerations editorial

Abstract

Not applicable.

<p>COVID-19 Clinical Trials Registered Worldwide for Drug Intervention: An Overview and Characteristic Analysis</p>

“…[11][12][13][14][15] A similar study analyzing COVID-19 clinical trials had a search time very close to ours, and they outline the results of some suitable drugs. 12 Therefore, we will focus on some of the latest research results for these drugs. Judging from the current ranking of drug popularity, the percentage of trials investigating "hydroxychloroquine" reached 7.47% (68), ranking first.…”

“…In the past few months, chloroquine and hydroxychloroquine were approved by the FDA for testing as a treatment for COVID-19. 11,12 Hydroxychloroquine is a chemically modified chloroquine derivative with a similar mechanism of action as chloroquine but better absorption and fewer side effects. 12 It can be seen from the "hydroxychloroquine" node connections in the Sankey diagram that the United States is the main contributor (36.76%, 25) to "hydroxychloroquine" investigations.…”

“…11,12 Hydroxychloroquine is a chemically modified chloroquine derivative with a similar mechanism of action as chloroquine but better absorption and fewer side effects. 12 It can be seen from the "hydroxychloroquine" node connections in the Sankey diagram that the United States is the main contributor (36.76%, 25) to "hydroxychloroquine" investigations. A multinational analysis of the largest sample of hydroxychloroquine trials indicated that the drug may cause severe arrhythmia and even sudden cardiac death in patients with COVID-19.…”