An overview of Bothrops erythromelas venom

Néry, Neriane Monteiro; Luna, Karla Patrícia de Oliveira; Fernandes, Carla Freire Celedônio; Zuliani, Juliana Pavan

doi:10.1590/0037-8682-0195-2016

Cited by 8 publications

(6 citation statements)

References 40 publications

(50 reference statements)

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“…Bothrops erythromelas venom presents no thrombin-like activity. The activity of this venom in the coagulation was attributed to a marked presence of prothrombin and activators of the factor X that lead to the formation of endogenous thrombin 8,9 . This venom contain toxins, such as serine proteinases, metalloproteinases (SVMPs), disintegrins and C-type lectin-like molecules.…”

Section: Discussionmentioning

confidence: 99%

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Thrombotic microangiopathy due to Bothrops erythromelas: a case report in Northeast Brazil

Mota

Albuquerque

Júnior

et al. 2020

Rev. Inst. Med. trop. S. Paulo

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Section: Discussionmentioning

confidence: 99%

“…Bothrops erythromelas venom presents the highest levels of factor X (FX) and prothrombin activators without showing a thrombin-like activity in comparison with other Bothrops venoms 8 . In the current study, the patient showed some evidence of coagulopathy (uncoagulable PT and aPTT).…”

Section: Discussionmentioning

confidence: 99%

Thrombotic microangiopathy due to Bothrops erythromelas: a case report in Northeast Brazil

Mota

Albuquerque

Júnior

et al. 2020

Rev. Inst. Med. trop. S. Paulo

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“…In a comparative analysis of the coagulant activity of the venoms of the different Bothrops spp. snakes, the venom of B. erythromelas showed high levels of factor X and prothrombin activators 49 . Bothrops spp.…”

Section: Discussionmentioning

confidence: 97%

Massive acute ischemic stroke after Bothrops spp. envenomation in southwestern Colombia: Case report and literature review

2022

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Bothrops spp. envenomation and its relationship with ischemic stroke has complex pathogenesis. Local effects such as edema, pain, redness, necrosis, and systemic manifestations like coagulation disorders, thrombosis, renal failure, and hemorrhage have been reported. Hemorrhagic stroke is a common neurological complication but ischemic stroke is poorly understood.We present here the case of a 50-year-old male with no comorbidities referred from a rural area in southwest Colombia with a Bothrops spp. snakebite on the left hand. On admission, the patient presented with a deterioration of consciousness and required mechanical ventilation assistance. The MRI showed multiple ischemic areas in the bilateral frontaltemporal and occipital regions. Two months later, the patient had a favorable resolution, although central paresis in the III and VI cranial nerves and positive Babinski’s sign persisted.As already mentioned, the pathophysiology of ischemic stroke due to snakebite is complex but the procoagulant activity of the venom components, the hypovolemic shock, the endothelial damage, and the thromboinflammation can explain it, and although it rarely occurs, it should be considered as a complication of ophidian accidents caused by Bothrops spp.

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“…Both Crotalus durissus ssp . and Bothrops erythromelas are widespread in the Caatinga biome and coexist with local communities 9 . Traditional medicine, especially the use of plants, is the frontline treatment administered in rural communities to face diseases and injuries 10,11 .…”

Section: Introductionmentioning

confidence: 99%

Insights on the inhibition properties ofJatromollistatin(a cyclic heptapeptide) againstCrotalus adamanteusmetalloendopeptidase using molecular docking analysis

Jucá

Ramos

Cilli

et al. 2022

J of Molecular Recognition

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Jatropha mollissima is endemic to Brazil and is used for traditional medicinal purposes, including the treatment of snakebite. In this study, latex obtained from this plant was fractioned using reversed-phase chromatography, and the fractions were then screened for peptides. A 755 g/mol peptide was obtained, and MS/MS analyses indicated it had a cyclic sequence (Pro-Leu-Gly-Val-Leu-Leu-Tyr). This peptide sequence was present in the Jatropha genome database, and an identity value of 90.71%, an Evalue of 0.0, and a score of 883 with NO-associated protein 1/chloroplastic/mitochondria of Jatropha curcas were obtained from the NCBI nonredundant protein sequence (nr) database. Molecular docking analyses performed with the peptide against a metalloendopeptidase belonging to Crotalus adamanteus snake venom suggested the cyclic peptide establishes favorable interactions with the catalytic site of the enzyme. Therefore, it could inhibit enzyme catalysis. This belief was corroborated by the formation of 6 hydrogen bonds with the linear form of the peptide. Tighter complexation of the cyclic form (41 kcal/mol more energetic) revealed better spatial blocking. The linear form outperformed the cyclic form in complexing the required energy, recruiting more catalytic residues (6/2), and in establishing more hydrogen bonds (6/3). However, cyclic folding provided a more significant spatial block within the catalytic site. The set of results suggests that the cycle peptide, here called Jatromollistatin, which was previously described as jatrophidin and pohlianin A in two other species of Jatropha, is a promising candidate to inhibit venom proteases. This belief is corroborated by the topical use of the latex for initial treatment of snakebites.

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An overview of Bothrops erythromelas venom

Cited by 8 publications

References 40 publications

Thrombotic microangiopathy due to Bothrops erythromelas: a case report in Northeast Brazil

Thrombotic microangiopathy due to Bothrops erythromelas: a case report in Northeast Brazil

Massive acute ischemic stroke after Bothrops spp. envenomation in southwestern Colombia: Case report and literature review

Insights on the inhibition properties ofJatromollistatin(a cyclic heptapeptide) againstCrotalus adamanteusmetalloendopeptidase using molecular docking analysis

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