Objective: Describe case of hemolytic-uremic syndrome (HUS) following snakebite. Method: Observational and descriptive study, case report type, carried out at the Paragominas, Pará State, Brasilian amazon. Case report: A woman was bitten by a snake, called jararaca, probably B. atrox, on her left foot, in the rural area of Paragominas, in 2019. She reported immediate pain, developed local edema and was referred to the Nova Esperança do Piriá City Hospital. It was rated as a mild accident and four ampoules of the bothropic antivenom were administered. On the third day, the patient presented mucosa skin paleness and jaundice, being transferred to Paragominas Emergency Care Unit. The case rating changed to severe and another eight ampoules of bothropic antivenom administered. Blood count, bilirubin dosage, renal, hepatic and pancreatic function tests, all altered results. The peripheral blood smear showed the presence of schizocytes and helmetcell. She was transferred to Intensive Care Unit and submitted to conservative treatment without plasmapheresis. After 22 days, she was discharged the hospital. Conclusion: This report describes the first HUS case, caused by snake envenoming, in the Brazilian Amazon region, with favorable evolution to specific treatment and conservative measures.