An overview of adapalene and benzoyl peroxide once-daily topical gel as a therapeutic option for acne

Abstract

Introduction: Acne vulgaris is the most common skin condition worldwide, and it is associated with substantial psychological comorbidity. Topical therapies-including retinoids, antibiotics, and benzoyl peroxide-are the cornerstones of treatment for patients with acne. The main barriers to care in the treatment of acne are poor adherence to therapy and lack of tolerability.Areas covered: Herein, the authors review the safety and efficacy of adapalene/benzoyl peroxide combination gel (0.1%/2.5% and 0.3%/2.5%), as well as its specific mechanisms of action that target acne vulgaris. The authors also offer an expert opinion on the use of adapalene/benzoyl peroxide gel compared with other topical therapies.Information Classification: General Expert opinion: Adapalene/benzoyl peroxide gel is safe and highly effective in the treatment of acne vulgaris. Its efficacy, tolerability, and ease-of-use are superior to other topical acne therapies, and its use does not contribute to antibiotic resistance. However, the cost of adapalene/benzoyl peroxide gel and lack of available generics may prohibit its use.

Endocrine Disorders and Hormonal Therapy for Adolescent Acne

“…Stability is highly vehicle-dependent. To compare with gels, creams and lotions, gel is more stable and active than others, however, oil base gels are more irritant than water-based [5]. Benzoyl peroxide is a potent bactericidal mediator with a broad spectrum of activity due to its oxidizing activity [6].…”

“…Nuclear hormone receptors (retinoic acid receptor RAR and retinoids X receptor RXR, each of which has three subtypes) and cytosolic binding proteins modulate their biological functions [9]. RAMBAs, such as liarozole, have been discovered and studied to treat all-trans-retinoic acid resistance [5,11]. Topical retinoids currently include tretinoin, adapalene, tazarotene, isotretinoin, metretinide, retinaldehyde, and retinoyl glucuronide.…”

“…There is no concurrence regarding the relative beneficial effects of the topical retinoids presently available (tretinoin, adapalene, tazarotene, and isotretinoin). Tolerability may be affected by the carrier in which a retinoid is administered [5,7]. Adapalene was commonly more well-tolerated than all other retinoids studied.…”

“…Tretinoin is now available in novel formulations with improved tolerability. One such product that includes tretinoin ambushed inside the porous copolymer microspheres is Retin-A Micro (0.1% gel) [5,13,14]. Avita contains tretinoin encapsulated in a polyoylprepolymer (PP-2).…”

“…Both molecules might not be used concurrently, since benzoyl peroxide can oxidize tretinoin [8]. The topical retinoid and topical antimicrobial conjugation have had more efficacious than either agent alone in lessening inflammatory and noninflammatory acne lesions [5]. Both topical clindamycin and benzoyl peroxide were used one time a day, and definite clindamycin phosphate 1.2% and tretinoin 0.025% in an aqueous-based gel type applied one time a day was considered be an efficient acne treatment [27,28].…”