Fabrication and Characterization of a Novel Wound Dressing with Clindamycin Loaded PVA Nanoparticles for Acne Treatment

Mandegari, Mansoor; Ghasemi‐Mobarakeh, Laleh; Varshosaz, Jaleh

doi:10.1007/s12221-022-4605-2

Cited by 2 publications

(3 citation statements)

References 57 publications

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“…For this reason, this synthetic polymer is often used in tissue engineering alone as well as in combination with other materials. Masks made from an aqueous solution of PVA and CLD obtained by electrospinning or electrospray technique can be used to treat skin wounds [101,102]. PVA mixed with carboxymethylated gum allowed to obtain a patch with very high absorbency, higher than that demonstrated by pure PVA, which resulted in a material for skin oozing wounds, which will be protected from microbial infection by CLD.…”

Section: Polymeric Carriers Of Clindamycinmentioning

confidence: 99%

Targeted Clindamycin Delivery Systems: Promising Options for Preventing and Treating Bacterial Infections Using Biomaterials

Słota,

Jampilek,

Sobczak-Kupiec

2024

IJMS

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Targeted therapy represents a real opportunity to improve the health and lives of patients. Developments in this field are confirmed by the fact that the global market for drug carriers was worth nearly $40 million in 2022. For this reason, materials engineering and the development of new drug carrier compositions for targeted therapy has become a key area of research in pharmaceutical drug delivery in recent years. Ceramics, polymers, and metals, as well as composites, are of great interest, as when they are appropriately processed or combined with each other, it is possible to obtain biomaterials for hard tissues, soft tissues, and skin applications. After appropriate modification, these materials can release the drug directly at the site requiring a therapeutic effect. This brief literature review characterizes routes of drug delivery into the body and discusses biomaterials from different groups, options for their modification with clindamycin, an antibiotic used for infections caused by aerobic and anaerobic Gram-positive bacteria, and different methods for the final processing of carriers. Examples of coating materials for skin wound healing, acne therapy, and bone tissue fillers are given. Furthermore, the reasons why the use of antibiotic therapy is crucial for a smooth and successful recovery and the risks of bacterial infections are explained. It was demonstrated that there is no single proven delivery scheme, and that the drug can be successfully released from different carriers depending on the destination.

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Section: Polymeric Carriers Of Clindamycinmentioning

confidence: 99%

Targeted Clindamycin Delivery Systems: Promising Options for Preventing and Treating Bacterial Infections Using Biomaterials

Słota,

Jampilek,

Sobczak-Kupiec

2024

IJMS

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“…These nanoparticles were sprayed on cotton for easy application to release the drug for longer duration. 171 Cui et al used electrospray to prepare clotrimazoleloaded micro/nanoparticles for topical delivery for treatment of fungal keratitis. 140 Similarly, Dillen et al developed electrosprayed Eudragit RS100 nanoparticles loaded with ciprofloxacin, an anti-microbial agent used for the treatment of skin and soft tissue infections.…”

Section: Topical Drug Deliverymentioning

confidence: 99%

“…To prepare this nanoparticle they used PVA (Polyvinyl alcohol) and clindamycin as which commonly used for treating acne. These nanoparticles were sprayed on cotton for easy application to release the drug for longer duration 171 . Cui et al used electrospray to prepare clotrimazole‐loaded micro/nanoparticles for topical delivery for treatment of fungal keratitis 140 .…”

Section: Electrospray Nanoparticles For Biomedical Applicationmentioning

confidence: 99%

Review on electrospray nanoparticles for drug delivery: Exploring applications

Patel,

Haemmerich

2024

Polymers for Advanced Techs

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Electrospraying has emerged as a versatile technique in the pharmaceutical field due to its potential in drug delivery and formulation. With its advantages of cost‐effectiveness, reproducibility, ease of operation, and scalability, electrospraying offers numerous benefits for pharmaceutical applications. Notably, the production of nanoparticles using electrospraying provides unique properties, including small size, drug encapsulation capabilities, biocompatibility, and scalability. Electrospray nanoparticles have demonstrated significant promise in various drug delivery routes, such as oral and topical administration. These nanoparticles enhance drug stability, protection, and permeability, effectively overcoming limitations associated with these routes. Moreover, electrospray nanoparticles have proven valuable in targeted drug delivery, improving drug bioavailability and efficacy. Their ability to penetrate tissues and cells enables enhanced drug delivery to specific sites within the body. Additionally, electrospray nanoparticles can be tailored with targeting ligands or responsive components for controlled release and combination therapy, exhibiting successful applications in cancer treatment and neurological disorders. Therefore, electrospray nanoparticle technology shows great promise in biomedical applications, offering a versatile platform for targeted drug delivery and therapeutic interventions. This comprehensive review examines the various drug delivery applications of electrospraying and provides insights into its possibilities and challenges. The paper discusses the principles, methods, and parameters of electrospraying, while also exploring its use in fabricating drug delivery systems, addressing poorly soluble drugs. By synthesizing the findings from multiple studies, this review offers a comprehensive understanding of electrospraying's current state and potential in the pharmaceutical industry.

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Fabrication and Characterization of a Novel Wound Dressing with Clindamycin Loaded PVA Nanoparticles for Acne Treatment

Cited by 2 publications

References 57 publications

Targeted Clindamycin Delivery Systems: Promising Options for Preventing and Treating Bacterial Infections Using Biomaterials

Targeted Clindamycin Delivery Systems: Promising Options for Preventing and Treating Bacterial Infections Using Biomaterials

Review on electrospray nanoparticles for drug delivery: Exploring applications

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