An Outbreak of Porcine Pleuropneumonia Caused by Actinobacillus pleuropneumoniae Serotype 1

Hayakawa, Yuuji; Komae, Hirofumi; Ide, Hisayoshi; Nakagawa, H; Yamaguchi, Tomohiro; Takeuchi, Kyuuhei; Matumoto, T.

doi:10.12935/jvma1951.44.790

Cited by 8 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chronic forms of pleuropneumonia may escape detection during the rearing period but are often recorded as pleuritis at slaughter, whereas the acute to per acute forms of the disease may lead to significant mortalities during the fattening period (Hayakawa and others 1991). …”

mentioning

confidence: 99%

“…Affected pigs may die within hours of being infected and medical treatment is required to ameliorate outbreaks of the disease in affected herds (Hayakawa and others 1991). In an attempt to minimise the exposure of growing pigs to microorganisms, age-segregated rearing systems have been used (Clark and others 1991, Holmgren and others 1999, Cleveland-Nielsen and others 2002, Busch and Jensen 2006).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Responses of pigs to a re‐challenge with Actinobacillus pleuropneumoniae after being treated with different antimicrobials following their initial exposure

et al. 2009

View full text Add to dashboard Cite

Four groups of six specific pathogen-free (SPF) pigs were inoculated intranasally with Actinobacillus pleuropneumoniae serotype 2 and treated with either enrofloxacin, tetracycline or penicillin at the onset of clinical disease, or left untreated. A fifth group was left uninoculated. The inoculated control and the penicillin-treated groups developed severe disease, but the groups treated with enrofloxacin and tetracycline recovered rapidly. All the inoculated pigs, except those treated with enrofloxacin developed serum antibodies to A pleuropneumoniae. On day 28, all five groups were challenged with A pleuropneumoniae without any subsequent treatment. The previously uninoculated control group and the enrofloxacin-treated group developed severe disease, but the three seropositive groups remained unaffected.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

Responses of pigs to a re‐challenge with Actinobacillus pleuropneumoniae after being treated with different antimicrobials following their initial exposure

et al. 2009

View full text Add to dashboard Cite

show abstract

“…At acute manifestations of actinobacillosis, clinical signs will rapidly spread through a population and mortality rates may be significantly increased (Hayakawa et al, 1991). During such circumstances the microbe is fairly easy to cultivate at necropsy.…”

Section: Introductionmentioning

confidence: 99%

Relationship between the Amounts of Antibodies to Actinobacillus pleuropneumoniae Serotype 2 Detected in Blood Serum and in Fluids Collected from Muscles of Pigs

Wallgren

Persson

2000

Journal of Veterinary Medicine, Series B

View full text Add to dashboard Cite

An indirect ELISA method, previously used to detect antibodies to Actinobacillus pleuropneumoniae serotype 2 in serum of pigs, was further developed aiming to measure antibodies to the microbe in muscle fluids. Serum and muscle fluid were collected from Specific Pathogen Free (SPF) pigs as well as from SPF pigs challenged with A. pleuropneumoniae which were either treated with effective antibiotics or left as infected controls. The antibody responses measured in serum correlated well to the clinical signs of respiratory disease observed and to pathological lesions found at necropsy performed 17 days postinfection. The amounts of antibodies monitored in serum and in muscle fluid collected from the diaphragm and the thigh, respectively, were compared. Higher concentrations of antibodies were assessed in serum than in diaphragm fluid, which in turn contained more antibodies per ml than fluid collected from the thigh. The amount of antibodies to A. pleuropneumoniae measured in fluid from the diaphragm diluted 1/50 correlated well with the quantity measured in serum diluted 1/1000 (r 2 = 0.87; P ³ 0.001). When validated by using serum antibody responses as a standard, the specificity of the ELISA employed in fluid from the diaphragm was found to be 100 %. The sensitivity was determined to be 88 % when calculated on seropositive pigs (A 450 = 0.3 in serum diluted 1/1000). That figure increased to 97 % if calculated on pigs expressing pronounced amounts of serum antibodies (A 450 − 0.5).

show abstract

“…Both agents predominantly cause infections with a chronic course, yielding no or only mild signs of respiratory disease. However, A. pleuropneumoniae may cause an acute to peracute infection with a swift onset of clinical signs which will spread rapidly through nonimmune herds, often causing a high mortality rate (HAYAKAWA et al, 1991). In these cases, an early initiated parenteral antibiotic treatment is necessary to reduce the clinical consequences and prevent mortality.…”

Section: Introductionmentioning

confidence: 99%

Experimental Infections with Actinobacillus pleuropneumoniae in Pigs ‐ 1. Comparison of five different Parentarel Antibiotic Treatments.

1999

Journal of Veterinary Medicine, Series B

View full text Add to dashboard Cite

SPF pigs aged 10 weeks were infected intranasally with Actinobacillus pleuropneumoniae serotype 2. After the onset of clinical symptoms of respiratory disease, which occurred 20 h post-infection, parenteral treatment with ceftiofur, danofloxacin, enrofloxacin, penicillin or tiamulin was initiated (n = 8 per group). Untreated groups, of which one was infected, served as controls. The uninfected control group did not show any signs of disease, while the infected control group was severely affected by the infection and also expressed a decreased weight gain following the challenge.Based on clinical signs, the magnitude of pathological lesions in the respiratory tract found at necropsy performed 17 days post-infection and the number of reisolates of A. pleuropneumoniae made at necropsy, treatments with the quinolones (danofloxacin and enrofloxacin) and the cephalosporine (ceftiofur) were superior to those with penicillin and tiamulin. The latter groups also developed antibodies to A. pleuropneumoniae to a larger extent. Some of the pigs treated with ceftiofur and danofloxacin developed antibodies to A. pleuropneumoniae, and the microbe was reisolated from ¼50% of these animals. In contrast, pigs treated with enrofloxacin did not develop antibodies to A. pleuropneumoniae, and the challenge strain was not found at necropsy.The performance with respect to daily weight gain and feed conversion corresponded well with the clinical signs developed and the findings made at necropsy. The decreased growth recorded during the acute phase of the disease was, to a large extent, caused by a reduced feed intake.

show abstract

An Outbreak of Porcine Pleuropneumonia Caused by Actinobacillus pleuropneumoniae Serotype 1

Cited by 8 publications

References 0 publications

Responses of pigs to a re‐challenge with Actinobacillus pleuropneumoniae after being treated with different antimicrobials following their initial exposure

Responses of pigs to a re‐challenge with Actinobacillus pleuropneumoniae after being treated with different antimicrobials following their initial exposure

Relationship between the Amounts of Antibodies to Actinobacillus pleuropneumoniae Serotype 2 Detected in Blood Serum and in Fluids Collected from Muscles of Pigs

Experimental Infections with Actinobacillus pleuropneumoniae in Pigs ‐ 1. Comparison of five different Parentarel Antibiotic Treatments.

Contact Info

Product

Resources

About