An Outbreak of Gram-Negative Bacteremia in Hemodialysis Patients Traced to Hemodialysis Machine Waste Drain Ports

Wang, S A; Levine, R B; Carson, Loretta A.; Arduino, Matthew J.; Killar, T; Grillo, Francesco; Pearson, Michele L.; Jarvis, William R.

doi:10.1086/501576

Cited by 44 publications

(21 citation statements)

References 15 publications

(15 reference statements)

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“…Patients undergoing hemodialysis can be infected by bacterial pathogens or endotoxins through contaminated dialysis machine units (356,362). MDR S. maltophilia isolates have been recovered from hemodialysate, tap water, and treated water samples (15).…”

Section: Nosocomial and Community-acquired Infectionsmentioning

confidence: 99%

Stenotrophomonas maltophilia: an Emerging Global Opportunistic Pathogen

2012

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SUMMARY Stenotrophomonas maltophilia is an emerging multidrug-resistant global opportunistic pathogen. The increasing incidence of nosocomial and community-acquired S. maltophilia infections is of particular concern for immunocompromised individuals, as this bacterial pathogen is associated with a significant fatality/case ratio. S. maltophilia is an environmental bacterium found in aqueous habitats, including plant rhizospheres, animals, foods, and water sources. Infections of S. maltophilia can occur in a range of organs and tissues; the organism is commonly found in respiratory tract infections. This review summarizes the current literature and presents S. maltophilia as an organism with various molecular mechanisms used for colonization and infection. S. maltophilia can be recovered from polymicrobial infections, most notably from the respiratory tract of cystic fibrosis patients, as a cocolonizer with Pseudomonas aeruginosa . Recent evidence of cell-cell communication between these pathogens has implications for the development of novel pharmacological therapies. Animal models of S. maltophilia infection have provided useful information about the type of host immune response induced by this opportunistic pathogen. Current and emerging treatments for patients infected with S. maltophilia are discussed.

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Section: Nosocomial and Community-acquired Infectionsmentioning

confidence: 99%

Stenotrophomonas maltophilia: an Emerging Global Opportunistic Pathogen

2012

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“…Less commonly, gramnegative bacteria are the cause of infection with the demonstration in 28% of cases 36,54 . Their occurrence is associated with the transmission from hemodialysis machines 55 . The most common route of infection entry is an angioaccess, followed by urinary tract, gastrointestinal tract and respiratory tract.…”

Section: Microbiologymentioning

confidence: 99%

INFECTIOUS COMPLICATIONS OF ARTERIOVENOUS ePTFE GRAFTS FOR HEMODIALYSIS

Bachleda¹,

Utíkal²,

Kalinová³

et al. 2010

BIOMED PAP

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“…5,6 Most reports of access-related infections in hemodialysis patients have incriminated staphylococcus organisms as the leading cause of bacteremia, while gram-negative bacteremia was considered to be uncommon. [17][18][19]21 We have recently experienced an increased rate of hemodialysisrelated gram-negative bacteremia at our institution and this motivated us to undertake this study.…”

Section: Introductionmentioning

confidence: 99%