An Outbreak of Aseptic Meningitis Due to Echovirus 30 in a High School Baseball Club-Possible Role of Severe Exercise for a High Attack Rate

Hayashi, Takeshi; Shirayoshi, Takamasa; Nagano, Takuro; Yaoita, Hiroyuki; Kogure, Shuji; Nariai, Hiroki; Natsumeda, Tomo; Taniuchi, Mayumi; Sandoh, Mitsuru; Sato, Yoshitake

doi:10.2169/internalmedicine.48.2298

Cited by 13 publications

(26 citation statements)

References 33 publications

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“…We recently experienced an outbreak of aseptic meningitis caused by echovirus 30 in a high school baseball club (Hayashi et al, 2009). Among the 43 members of the baseball club related to our case, 12 were admitted to our hospital, 5 to other hospitals, and all of the other members developed a fever and headache even though they were not admitted to hospitals.…”

Section: Echovirusmentioning

confidence: 69%

“…However, a few people show complications such as seizure, coma, and movement disorders. There were no such cases in the outbreak we experienced (Hayashi et al, 2009), but 5 to 10% of infant cases show severe complications (Rorabaugh et al, 1993). Infant cases may suffer from neurological sequela such as altered language development, which suggests a higher vulnerability of infants to this virus.…”

Section: Clinical Featuresmentioning

confidence: 92%

“…We investigated the electroencepharograms in several cases of enterovirus meningitis (Hayashi et al, 2009), but no cases revealed abnormal findings. The results of electroencephalograms may be different based on the causative serotype, but this issue has not been fully elucidated.…”

Section: Clinical Featuresmentioning

confidence: 99%

“…Echoviruses 9 and 71 are notorious for their frank brain damage (Fowlkes et al, 2008). However, even in the same serotype-caused outbreak, the clinical picture may be different for those affected by the viruses (Akiyoshi et al, 2007;Faustini et al, 2006;Hayashi et al, 2009;Helfand et al, 1994;Mohle-Boetani et al, 1999;Vieth et al, 1999). Mutations in VP1 change the virulence, as may other mutations.…”

Section: Clinical Featuresmentioning

confidence: 99%

“…Some studies have revealed that enteroviruses are also the most common cause of meningitis in infants; more than 90% of patients younger than 1 year old who develop aseptic meningitis are identified to have an enterovirus infection, although this virus is responsible for only about 50% of adult cases of aseptic meningitis Marier et al, 1975). In this chapter, we review the features of enteroviruses and meningitis caused by this pathogen, with reference to an outbreak we recently experienced (Hayashi et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Aseptic Meningitis Caused by Enteroviruses

Hayashi¹,

Shirayoshi²,

Ebitani³

2012

Meningitis

Self Cite

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Section: Echovirusmentioning

confidence: 69%

Section: Clinical Featuresmentioning

confidence: 92%

Section: Clinical Featuresmentioning

confidence: 99%

Section: Clinical Featuresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Aseptic Meningitis Caused by Enteroviruses

Hayashi¹,

Shirayoshi²,

Ebitani³

2012

Meningitis

Self Cite

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Genetic diversity of echovirus 30 involved in aseptic meningitis cases in Brazil (1998–2008)

Santos

Costa

Tavares

et al. 2011

Journal of Medical Virology

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Aseptic meningitis is one of the most common neurological disorders caused by enteroviruses. Among them, Echovirus 30 (E30) is described as the main etiological agent of many outbreaks and sporadic cases. This study investigated the genomic variability of E30 isolated from the cerebrospinal fluid (CSF) of aseptic meningitis cases that occurred from 1998 to 2008 in Brazil. Over a 10-year period (1998-2008), 302 non-polio enteroviruses were isolated, of which 177 were identified as E30 (58.6%). Phylogenetic analysis of the complete VP1 gene (876 nt) of 48 E30 isolates was performed and compared with additional Brazilian and foreign strains. E30 VP1 sequences segregated into three distinct major groups and seven subgroups, which were linked to the isolation year. In general, sequence divergence among E30 strains ranged from 0.2% to 13.8%. A common direct ancestor for this set of E30 strains was not defined. Brazilian isolates from Group I were related genetically to a 1997 USA isolate and both may have a common origin. Group III representatives showed close relationship to the 2007 Argentinean isolates. The present results complement existing data on the molecular characterization and genetic variability of E30 and may contribute to the understanding of the epidemiology of aseptic meningitis in the region.

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A large Finnish echovirus 30 outbreak was preceded by silent circulation of the same genotype

et al. 2010

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An outbreak of echovirus 30 (E-30) in 2009 was confirmed by both frequent isolation of the virus from sewage as well as from patient samples in Finland. Over the last 10 years E-30 had only been isolated sporadically in Finland. We here study the phylogenetic relationships of the strains from the outbreak in the context of E-30 circulation over the last 20 years. The analyzed region comprised 276 nucleotides in the 5' end of VP1 (nucleotides 132-407 in the VP1 of the E-30 Bastianni strain). The Finnish strains were clustered into at least four distinct genogroups, with seven clusters exceeding the genotype demarcation of 12% and the 2009 epidemic strains forming the largest genogroup VII. Moreover, we detected largely divergent genotypes in 2007 and 2009. Interestingly, close genetic relatives of the epidemic strains had already been isolated a few years before the outbreak. Phylodynamic analysis estimated 8.9 years (95% highest posterior density intervals 7.0-11.0) as the age of genogroup VII, indicating a probable origin and evolutionary history prior to its introduction and epidemic expansion in Finland. Finally, the most recent common ancestor for the current E-30 diversity dates back to 1939 (95% highest posterior density intervals 1913-1956).

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An Outbreak of Aseptic Meningitis Due to Echovirus 30 in a High School Baseball Club-Possible Role of Severe Exercise for a High Attack Rate

Abstract: In September 2008, an

Cited by 13 publications

References 33 publications

Aseptic Meningitis Caused by Enteroviruses

Aseptic Meningitis Caused by Enteroviruses

Genetic diversity of echovirus 30 involved in aseptic meningitis cases in Brazil (1998–2008)

A large Finnish echovirus 30 outbreak was preceded by silent circulation of the same genotype

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