An organoselenium compound improves behavioral, endocrinal and neurochemical changes induced by corticosterone in mice

Gai, Bibiana Mozzaquatro; Bortolatto, Cristiani F.; Heck, Suélen Osório; Stein, André L.; Zeni, Gilson; Nogueira, Cristina W.

doi:10.1007/s00213-013-3361-9

Cited by 21 publications

(24 citation statements)

References 52 publications

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“…The latency to chew the pellet was recorded by an observer blind to this test. Immediately afterwards animals were returned in their home cage (Gai et al, 2014;Tang et al, 2015).…”

Section: Novelty Suppressed Feeding Testmentioning

confidence: 99%

Wuling powder prevents the depression-like behavior in learned helplessness mice model through improving the TSPO mediated-mitophagy

Zheng

Wang

et al. 2016

Journal of Ethnopharmacology

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“…The latency to chew the pellet was recorded by an observer blind to this test. Immediately afterwards animals were returned in their home cage (Gai et al, 2014;Tang et al, 2015).…”

Section: Novelty Suppressed Feeding Testmentioning

confidence: 99%

Wuling powder prevents the depression-like behavior in learned helplessness mice model through improving the TSPO mediated-mitophagy

Zheng

Wang

et al. 2016

Journal of Ethnopharmacology

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“…Considering that the MSG model induced a deregulation in the HPA axis (Dolnikoff et al 2001), which results in an increase in plasma corticosterone levels associated to a deregulation in the metabolic homeostasis and that another organoselenium compound normalizes the levels of corticosterone in mice (Gai et al 2014), the possibility that (p-ClPhSe) 2 restored hypercorticosteronemia induced by MSG administration could not be ruled out. As the limitations of the present study, the effects of (p-ClPhSe) 2 on the HPA axis and AMPK have not been investigated.…”

Section: Discussionmentioning

confidence: 99%

Homeostatic effect of p-chloro-diphenyl diselenide on glucose metabolism and mitochondrial function alterations induced by monosodium glutamate administration to rats

et al. 2015

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The metabolic syndrome is a group of metabolic alterations considered a worldwide public health problem. Organic selenium compounds have been reported to have many different pharmacological actions, such as anti-hypercholesterolemic and anti-hyperglycemic. The aim of this study was to evaluate the effect of p-chloro-diphenyl diselenide (p-ClPhSe)2, an organic selenium compound, in a model of obesity induced by monosodium glutamate (MSG) administration in rats. The rats were treated during the first ten postnatal days with MSG and received (p-ClPhSe)2 (10 mg/kg, intragastrically) from 45th to 51 th postnatal day. Glucose, lipid and lactate levels were determined in plasma of rats. Glycogen levels and activities of tyrosine aminotransferase, hexokinase, citrate synthase and glucose-6-phosphatase (G-6-Pase) were determined in livers of rats. Renal G-6-Pase activity was also determined. The purine content [Adenosine triphosphate (ATP), adenosine diphosphate (ADP) and adenosine monophosphate] and mitochondrial functionality in the liver were also investigated. p-(ClPhSe)2 did not alter the reduction in growth performance and in the body weight caused by MSG but reduced epididymal fat deposition of rats. p-(ClPhSe)2 restored glycemia, triglycerides, cholesterol and lactate levels as well as the glucose metabolism altered in rats treated with MSG. p-(ClPhSe)2 restored hepatic mitochondrial dysfunction and the decrease in citrate synthase activity and ATP and ADP levels caused by MSG in rats. In summary, (p-ClPhSe)2 had homeostatic effects on glucose metabolism and mitochondrial function alterations induced by MSG administration to rats.

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“…Interestingly, recent studies have demonstrated the involvement of serotonergic system in the antidepressant-like action of F-DPS (Gai et al, 2013;Gay et al, 2010). Acute antiimmobility effect of this selenophene compound was significantly blocked by serotoninergic receptor antagonists and both acute and subchronic treatments with F-DPS inhibited serotonin uptake in a synaptosomal preparation from prefrontal cortex and hippocampus of mice (Gai et al, 2013;Gay et al, 2010). Thus, we considered F-DPS as the most promising selenophene to further investigate the mechanisms involved on its antidepressant-like action.…”

Section: Ctrlmentioning

confidence: 99%

“…Over the last decade preclinical studies have demonstrated that several organoselenium compounds have pharmacological properties including antioxidant, anticonvulsant, neuroprotective and antidepressant actions (Bruning et al, 2011;Dias et al, 2014;Gai et al, 2013;Mahadevan et al, 2013;Pinton et al, 2013;Wilhelm et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…We highlight the selenophene class, a specific group of heterocyclic selenium-containing molecules whose members have been shown to produce antidepressant-like properties (Gai et al, 2014(Gai et al, , 2013Gay et al, 2010). A recent study showed that the administration of a single dose of 3-chalcogen selenophenes (50 mg/kg) reduced the immobility time in the mouse forced swimming test (FST); structureactivity relationship studies demonstrated that the phenyl group at the 2-position and an organoselenium group at the 3-position of the five-member ring are essential for their antidepressant-like activity .…”

Section: Introductionmentioning

confidence: 99%

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ERK1/2 phosphorylation is involved in the antidepressant-like action of 2,5-diphenyl-3-(4-fluorophenylseleno)-selenophene in mice

Gai

Sanna

Stein

et al. 2014

European Journal of Pharmacology

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a b s t r a c tWe investigated the antidepressant-like action of 5 compounds belonging to the selenophene class. The involvement of ERK and CREB activation in this action was also demonstrated. In the experiment 1, timecourse and dose-response effect of H-DPS, CH 3 -DPS, Cl-DPS, F-DPS and CF 3 -DPS were accompanied in the mouse forced swimming test (FST). Firstly, animals received compounds at a dose of 50 mg/kg, by intragastric (i.g.) route, at different times (15-240 min) before test. Results showed that the peak of maximum anti-despair behavior induced by Cl-DPS, F-DPS and CF 3 -DPS was at 30 min; maximum effect of H-DPS and CH 3 -DPS was found at 60 min, which was maintained until 120 min. Regarding doseresponse effect, all compounds reduced immobility time and increased latency for the first episode of immobility at a dose of 50 mg/kg. In addition, F-DPS also showed antidepressant-like action at a dose of 25 mg/kg, whilst H-DPS, CH 3 -DPS, Cl-DPS and CF 3 -DPS were not effective at lower doses. Thus, F-DPS was chosen for further investigation of its mechanism of action. Experiment 2 showed that treatment of animals with F-DPS (50 mg/kg, i.g.) significantly increased phosphorylated ERK1/2 levels in the prefrontal cortex and hippocampus; however, pCREB levels were not affected. Additionally, in the experiment 3 anti-immobility effect of F-DPS was completely blocked by pretreatment of animals with PD 98,059, an inhibitor of ERK phosphorylation, suggesting that ERK signalling activation is involved in its antidepressant-like action in mice. Together our data appoint F-DPS as a promising molecule for the development of a new antidepressant therapy.

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An organoselenium compound improves behavioral, endocrinal and neurochemical changes induced by corticosterone in mice

Abstract: These findings suggest a modulation of both serotonergic and glutamatergic systems by F-DPS after a long-term corticosterone exposure in mice, which may be involved in the antidepressant- and anxiolytic-like actions of this organoselenium compound.

Cited by 21 publications

References 52 publications

Wuling powder prevents the depression-like behavior in learned helplessness mice model through improving the TSPO mediated-mitophagy

Wuling powder prevents the depression-like behavior in learned helplessness mice model through improving the TSPO mediated-mitophagy

Homeostatic effect of p-chloro-diphenyl diselenide on glucose metabolism and mitochondrial function alterations induced by monosodium glutamate administration to rats

ERK1/2 phosphorylation is involved in the antidepressant-like action of 2,5-diphenyl-3-(4-fluorophenylseleno)-selenophene in mice

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