An Organic Field-effect Transistor with an Extended-gate Electrode Capable of Detecting Human Immunoglobulin A

Abstract

We herein report on the development of an extended-gate type organic field-effect transistor (OFET)-based immunosensor for the detection of human immunoglobulin A (IgA). The titration results of IgA exhibited shifts in the transfer characteristics of the OFET sensor device with increasing IgA concentration. A linear detection range from 0 to 10 μg/mL was realized with a detection limit of 2.1 μg/mL, indicating that the OFET-based immunosensor can be potentially applied to the monitoring of infectious diseases and psychological stress in daily life.

An Organic Transistor-based Electrical Assay for Copper(II) in Water

“…The separated structure between the organic TFT and the detection part can provide an accurate assay for the analyte in water. 15,16 This study employed the following electrical key components for high-reliable sensing system, that is, poly{2,5-bis(3-hexadecylthiophene-2-yl)-thieno[3,2-b]thiophene} (PBTTT) 17 as an active charge-transporter and tetradecylphosphonic acid (TDPA) 18 on alumina as an insulating material ( Fig. 1(b)), respectively.…”

Printed Organic Transistor‐Based Enzyme Sensor for Continuous Glucose Monitoring in Wearable Healthcare Applications

“…The extendedgate type transistor is advantageous for stable and reproducible detection of analytes in a sample solution, because the sensing portion immersed in the solution can be completely isolated from the driving portion. We have developed the extendedgate type organic transistor-based biosensors using different types of bioreceptors: antibody, [16][17][18][19][20] ionophore, [21] and enzyme. [22][23][24] Especially, enzyme-based biosensors were found suitable for selective detection of small-sized metabolites such as glucose and lactate in the bodily fluids.…”

Influence of Bioreceptor Layer Structure on Myelin Basic Protein Detection using Organic Field Effect Transistor‐Based Biosensors

“…OFET‐based biosensors are being widely studied for potentially fast clinical diagnostics, with the advantages of flexibility, sensitivity, and low cost . Particularly, OFET‐based biosensors for protein sensing have progressed remarkably for label‐free analyte detection based on the specific immune binding property innate to particular antibodies . By the adjustment of device structures, various challenges have been successfully overcome.…”

“…With the help of the gold‐thiol chemistry afforded by Au NPs, the thrombin aptamer can be easily immobilized on the device by chemical binding. Moreover, some researchers used gold electrodes as the gate of OFET‐based devices, which use the same mechanism for immobilizing biomolecules on the devices …”