An optimized optrode for continuous potassium monitoring in whole blood

Malavolti, E.; Cagnini, A.; Caputo, Giuseppe; Ciana, Leopoldo Della; Mascini, Marco

doi:10.1016/s0003-2670(99)00508-5

Cited by 11 publications

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ion sensors, such as ion-selective electrodes/optodes (ISEs/ISOs) based on a water-immiscible phase containing ion-specific carriers (ionophores), have been developed for the determination of over 60 different ions over the past decades. − Compared to ISEs that rely on potentiometric measurements using a two-electrode configuration, ISOs are power/instrument-free sensors that enable quantifiable optical changes produced by selective extraction of ionic analytes into the sensing phase. Therefore, the simple and cost-effective nature of ISOs, along with their analytical options for providing both a semiquantitative visual readout and more quantitative measurements assisted by portable cameras/smartphones equipped with color analysis software, make the optical ion sensors highly suitable for modern biomedical, , environmental, , and food security applications, especially in limited-resource settings.…”

Section: Introductionmentioning

confidence: 99%

Plasticizer-Free Thin-Film Sodium-Selective Optodes Inkjet-Printed on Transparent Plastic for Sweat Analysis

Zhang

Wang

Decker

et al. 2020

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

A novel strategy to functionalize transparent flexible plastic films with an optical ion-sensing layer using an inkjet-printing technology is described. The hydrophobic sensing chemicals that include a sodium ionophore, a lipophilic proton chromoionophore, and a lipophilic ion-exchanger are co-deposited onto substrates such as transparent polyester film sheets in the absence of any plasticizer and/or hydrophobic polymer matrix. The inkjet-printing process enables the formation of optode films with nanoscale thickness/roughness that readily facilitate interfacing with aqueous samples. Using a smartphone detector, the colorimetric response of the optodes is shown to reach 95% of equilibrium values within 100 s in response to different concentrations of sodium ions, which is more rapid than traditional ion-selective optodes based on plasticized PVC films as the sensing layer. The new optodes also exhibit high selectivity to Na+ over interfering ions including K+, Ca2+, and Mg2+. Chemical leaching experiments show that the highly hydrophobic optode components remain in place on the plastic substrate surface. Hence, excellent sensor stability and fully reversible optical responses are obtained, which is essential for potential continuous monitoring applications. Further testing of the sensors with undiluted human sweat samples is shown to yield accurate values for sodium concentrations. Therefore, the use of plasticizer-free ion-selective optode nanolayers that enable highly selective ion sensing on a clear plastic support is likely to expand the range of available chemical sensors suited for preparing wearable real-time sweat analysis devices.

show abstract

Section: Introductionmentioning

confidence: 99%

Plasticizer-Free Thin-Film Sodium-Selective Optodes Inkjet-Printed on Transparent Plastic for Sweat Analysis

Zhang

Wang

Decker

et al. 2020

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…Potassium monitoring in serum, urine, and foods is very important in the clinical and medical fields, being one of the most important routine analysis performed in a clinical laboratory [ 1 ]. From the potassium determination, medical information concerning physical conditions of the patients can be obtained in the cases where renal diseases, hypopotassemia, alkalosis, cirrhosis of liver, diuretic drugs, etc.…”

Section: Introductionmentioning

confidence: 99%

An Electrochemical Sensor Based on Nanostructured Hollandite-type Manganese Oxide for Detection of Potassium Ions

Lima

Bocchi

Gomes

et al. 2009

Sensors

View full text Add to dashboard Cite

Abstract:The participation of cations in redox reactions of manganese oxides provides an opportunity for development of chemical sensors for non-electroactive ions. A sensor based on a nanostructured hollandite-type manganese oxide was investigated for voltammetric detection of potassium ions. The detection is based on the measurement of anodic current generated by oxidation of Mn(III) to Mn(IV) at the surface of the electrode and the subsequent extraction of the potassium ions into the hollandite structure. In this work, an amperometric procedure at an operating potential of 0.80 V (versus SCE) is exploited for amperometric monitoring. The current signals are linearly proportional to potassium ion concentration in the range 4.97 × 10 −5 to 9.05 × 10 −4 mol L −1 , with a correlation coefficient of 0.9997.

show abstract

Colorimetric ionophore-based coextraction titrimetry of potassium ions

Thajee

Wang

Grudpan

et al. 2018

Analytica Chimica Acta

View full text Add to dashboard Cite

Potassium ion concentration can be successfully determined volumetrically by moving the titration from a homogeneous phase to a two phase solvent system. This is because potassium can be readily complexed in a selective and thermodynamically stable manner by ionophores such as valinomycin. Previous work demonstrated the successful titration of potassium by ion-exchange into an organic phase containing valinomycin, but the sample itself served as titrant, which is not sufficiently practical for routine applications. This problem is overcome here by a co-extraction based approach, with the sodium salt of the water soluble lipophilic anion tetraphenylborate as titrant. The extraction of potassium tetraphenylborate must be preferred over that of the hydrogen ion-tetraphenylborate pair, which is used to indicate the endpoint by the presence of a lipophilic indicator in the organic phase. This is controlled by the sample pH, which for the conditions chosen here is around 7 for optimal sharpness and accuracy of the endpoint. The approach is demonstrated in a colorimetric detection approach, by use of a tethered digital camera and subsequent automated analysis of the resulting image files. The potassium analysis in a variety of samples is successfully demonstrated, including blood serum.

show abstract

An optimized optrode for continuous potassium monitoring in whole blood

Cited by 11 publications

References 10 publications

Plasticizer-Free Thin-Film Sodium-Selective Optodes Inkjet-Printed on Transparent Plastic for Sweat Analysis

Plasticizer-Free Thin-Film Sodium-Selective Optodes Inkjet-Printed on Transparent Plastic for Sweat Analysis

An Electrochemical Sensor Based on Nanostructured Hollandite-type Manganese Oxide for Detection of Potassium Ions

Colorimetric ionophore-based coextraction titrimetry of potassium ions

Contact Info

Product

Resources

About