An optimized analog of antimicrobial peptide Jelleine-1 shows enhanced antimicrobial activity against multidrug resistant P. aeruginosa and negligible toxicity in vitro and in vivo

Zhou, Jingjing; Zhang, Lishi; He, Yuhang; Liu, Kexin; Zhang, Fangfang; Zhang, Hanru; Lü, Yanjun; Yang, Changyan; Zhao-peng, Wang; Fareed, Muhammad Subaan; Liang, Xiaolei; Yan, Wenjin; Wang, Kairong

doi:10.1016/j.ejmech.2021.113433

Cited by 35 publications

(39 citation statements)

References 52 publications

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“…The peptides R23F, R23DI, and R23EI demonstrated MIC around 12 μM against individual strains of MRSA and S. aureus indicating their antimicrobial activity at the level of peptide antibiotic polymyxin B [ 56 ]. The antimicrobial effect of the peptides against other strains and pathogenic microorganisms can be increased due to amino acid modifications of the sequence of antimicrobial peptides, for example as was done for jelleine-1 [ 57 ]. Based on the experiments carried out on the effect of the R23DI peptide on S. aureus and MRSA, it can be concluded that the R23DI peptide disrupts the cell wall of MRSA strain ATCC 43300 cells ( Figure 9 ) and does not destroy the cell wall when exposed to the S. aureus strain 209P cells ( Figure 10 ).…”

Section: Discussionmentioning

confidence: 99%

Multiple Antimicrobial Effects of Hybrid Peptides Synthesized Based on the Sequence of Ribosomal S1 Protein from Staphylococcus aureus

Кравченко

Domnin

Grishin

et al. 2022

IJMS

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The need to develop new antimicrobial peptides is due to the high resistance of pathogenic bacteria to traditional antibiotics now and in the future. The creation of synthetic peptide constructs is a common and successful approach to the development of new antimicrobial peptides. In this work, we use a simple, flexible, and scalable technique to create hybrid antimicrobial peptides containing amyloidogenic regions of the ribosomal S1 protein from Staphylococcus aureus. While the cell-penetrating peptide allows the peptide to enter the bacterial cell, the amyloidogenic site provides an antimicrobial effect by coaggregating with functional bacterial proteins. We have demonstrated the antimicrobial effects of the R23F, R23DI, and R23EI hybrid peptides against Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), Pseudomonas aeruginosa, Escherichia coli, and Bacillus cereus. R23F, R23DI, and R23EI can be used as antimicrobial peptides against Gram-positive and Gram-negative bacteria resistant to traditional antibiotics.

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Section: Discussionmentioning

confidence: 99%

Multiple Antimicrobial Effects of Hybrid Peptides Synthesized Based on the Sequence of Ribosomal S1 Protein from Staphylococcus aureus

Кравченко

Domnin

Grishin

et al. 2022

IJMS

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“…Also, synergistic effect and anti-biofilm activity of an AMP (Pt5–1c; a derivative of phosvitin) along with oxacillin, vancomycin, streptomycin and azithromycin has been suggested against MDR pathogens such as S. aureus , E. coli and K. pneumoniae [216] . An analog of AMP Jelleine-1 (extracted from the royal jelly of honeybees) has been implicated in the potent inhibition of biofilm formation of MDR pathogen P. aeruginosa [217] . Oh et al has shown the anti-biofilm and anti-inflammatory effects of Lycosin-II (an AMP isolated from spiders) against MDR S. aureus and P. aeruginosa infections [218] .…”

Section: Application Of Amps Against Mdr Pathogensmentioning

confidence: 99%

Multidrug resistance crisis during COVID-19 pandemic: Role of anti-microbial peptides as next-generation therapeutics

Sharma

Barman

Joshi

et al. 2022

Colloids and Surfaces B: Biointerfaces

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The decreasing effectiveness of conventional drugs due to multidrug-resistance is a major challenge for the scientific community, necessitating development of novel antimicrobial agents. In the present era of coronavirus 2 (COVID-19) pandemic, patients are being widely exposed to antimicrobial drugs and hence the problem of multidrug-resistance shall be aggravated in the days to come. Consequently, revisiting the phenomena of multidrug resistance leading to formulation of effective antimicrobial agents is the need of the hour. As a result, this review sheds light on the looming crisis of multidrug resistance in wake of the COVID-19 pandemic. It highlights the problem, significance and approaches for tackling microbial resistance with special emphasis on anti-microbial peptides as next-generation therapeutics against multidrug resistance associated diseases. Antimicrobial peptides exhibit exceptional mechanism of action enabling rapid killing of microbes at low concentration, antibiofilm activity, immunomodulatory properties along with a low tendency for resistance development providing them an edge over conventional antibiotics. The review is unique as it discusses the mode of action, pharmacodynamic properties and application of antimicrobial peptides in areas ranging from therapeutics to agriculture.

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“…The authors demonstrated that jelleine-I has an inhibitory effect against this certain pathogen, and the development of antimicrobial agents that involve jelleine-I is feasible [100]. Moreover, Zhou et al (2021) [101] developed several jelleine-I analogs that exhibit intensified antimicrobial effects against P. aeruginosa. By investigating the activity of the developed analogs, the authors concluded that one certain analog, that expresses in its sequence additional arginine and leucine, displays improved antibacterial effect against P. aeruginosa.…”

Section: Rj Against P Aeruginosamentioning

confidence: 99%

Royal Jelly as a Nutraceutical Natural Product with a Focus on Its Antibacterial Activity

2022

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Royal jelly (RJ) is one of the most valued natural products and is known for its health-promoting properties. Due to its therapeutic effects, it has been used in medicine since antiquity. Nowadays, several studies indicate that RJ acts as a powerful antimicrobial agent. Indeed, researchers shed light on its antioxidant and anticancer activity. RJ’s biological properties are related to its bioactive compounds, such as proteins, peptides, phenolic, and fatty acids. The aim of this review is to highlight recent findings on RJ’s main bioactive compounds correlated with its health-promoting properties. The available literature suggests that these bioactive compounds can be used as an alternative approach in order to enhance human health. Moreover, throughout this paper, we underline the prominent antibacterial effect of RJ against several target bacterial strains. In addition, we briefly discuss other therapeutic activities, such as antioxidative and anticancer effects, of this outstanding natural product.

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An optimized analog of antimicrobial peptide Jelleine-1 shows enhanced antimicrobial activity against multidrug resistant P. aeruginosa and negligible toxicity in vitro and in vivo

Cited by 35 publications

References 52 publications

Multiple Antimicrobial Effects of Hybrid Peptides Synthesized Based on the Sequence of Ribosomal S1 Protein from Staphylococcus aureus

Multiple Antimicrobial Effects of Hybrid Peptides Synthesized Based on the Sequence of Ribosomal S1 Protein from Staphylococcus aureus

Multidrug resistance crisis during COVID-19 pandemic: Role of anti-microbial peptides as next-generation therapeutics

Royal Jelly as a Nutraceutical Natural Product with a Focus on Its Antibacterial Activity

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