Royal Jelly as a Nutraceutical Natural Product with a Focus on Its Antibacterial Activity

Bagameri, Lilla; Baci, Gabriela-Maria; Dezmirean, Daniel Severus

doi:10.3390/pharmaceutics14061142

Cited by 13 publications

(2 citation statements)

References 141 publications

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“…Two B. sonorensis strains (X1 and X2) were isolated from royal jelly samples, which has never been reported before. The high nutritional value of royal jelly could make this substance as a good growth medium for these bacteria [ 58 ]. Alternatively, the presence of Bacillus strains in the royal jelly samples could be the result of a contamination, since bees mix royal jelly with pollen and nectar to produce worker jelly [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

Characterization of Bacillus Strains from Natural Honeybee Products with High Keratinolytic Activity and Antimicrobial Potential

et al. 2023

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Two efficient feather-degrading bacteria were isolated from honeybee samples and identified as Bacillus sonorensis and Bacillus licheniformis based on 16S rRNA and genome sequencing. The strains were able to grow on chicken feathers as the sole carbon and nitrogen sources and degraded the feathers in a few days. The highest keratinase activity was detected by the B. licheniformis CG1 strain (3800 U × mL−1), followed by B. sonorensis AB7 (1450 U × mL−1). Keratinase from B. licheniformis CG1 was shown to be active across a wide range of pH, potentially making this strain advantageous for further industrial applications. All isolates displayed antimicrobial activity against Micrococcus luteus; however, only B. licheniformis CG1 was able to inhibit the growth of Mycobacterium smegmatis. In silico analysis using BAGEL and antiSMASH identified gene clusters associated with the synthesis of non-ribosomal peptide synthetases (NRPS), polyketide synthases (PKSs) and/or ribosomally synthesized and post-translationally modified peptides (RiPPs) in most of the Bacillus isolates. B. licheniformis CG1, the only strain that inhibited the growth of the mycobacterial strain, contained sequences with 100% similarity to lichenysin (also present in the other isolates) and lichenicidin (only present in the CG1 strain). Both compounds have been described to display antimicrobial activity against distinct bacteria. In summary, in this work, we have isolated a strain (B. licheniformis CG1) with promising potential for use in different industrial applications, including animal nutrition, leather processing, detergent formulation and feather degradation.

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Section: Discussionmentioning

confidence: 99%

Characterization of Bacillus Strains from Natural Honeybee Products with High Keratinolytic Activity and Antimicrobial Potential

et al. 2023

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“…These properties are associated with the presence of phenolic compounds, such as p -coumaric (1.2–12.2 mg/g) and ferulic acid (0.3–11.0 mg/g), and flavonoids (pinocembrin, catechin, caffeic acid phenethyl ester, and galangin) present in propolis [ 12 ]. Lastly, royal jelly or “bee milk” is an acidic colloid composed of water (60–70%), proteins (9–18%), sugars (7–18%), lipids (3–6%), and other compounds (0.8–3%), such as free amino acids and fatty acids [ 13 , 14 ]. Due to its antimicrobial, antioxidant, antiaging, and immunomodulatory properties, it is the most studied bee product [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Thyme and Chestnut Honeys Enriched with Bee Products against Benzo(a)pyrene-Induced DNA Damage

Sánchez-Martín

Haza

Iriondo‐DeHond

et al. 2022

IJERPH

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The aim of the present study was to validate the cytotoxicity, genotoxicity, and preventive potential against benzo(a)pyrene (BaP)-induced DNA damage of nine samples of thyme and chestnut honeys enriched with bee products (royal jelly and propolis, 2–10%). Cell viability was determined by the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay (0–250 mg/mL) to select nontoxic concentrations, and DNA damage (0.1–10 μg/mL) was evaluated by the alkaline single-cell gel electrophoresis or comet assay. Treatment with honey samples or royal jelly and propolis did not affect the viability of HepG2 cells up to 100 and 50 mg/mL, respectively. Treatment with 100 μM BaP significantly increased (p ≤ 0.001) the levels of the DNA strand breaks. None of the tested concentrations (0.1–10 μg/mL) of the honey samples (thyme and chestnut), royal jelly, and propolis caused DNA damage per se. All tested samples at all the concentrations used decreased the genotoxic effect of BaP. In addition, all mixtures of thyme or chestnut honeys with royal jelly or propolis showed a greater protective effect against BaP than the samples alone, being the thyme and chestnut honey samples enriched with 10% royal jelly and 10% propolis the most effective (70.4% and 69.4%, respectively). The observed protective effect may be associated with the phenolic content and antioxidant capacity of the studied samples. In conclusion, the thyme and chestnut honey samples enriched with bee products present potential as natural chemoprotective agents against the chemical carcinogen BaP.

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Can egg yolk antibodies terminate the CSBV infection in apiculture?

Wang

Huang

et al. 2023

Virus Research

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Royal Jelly as a Nutraceutical Natural Product with a Focus on Its Antibacterial Activity

Cited by 13 publications

References 141 publications

Characterization of Bacillus Strains from Natural Honeybee Products with High Keratinolytic Activity and Antimicrobial Potential

Characterization of Bacillus Strains from Natural Honeybee Products with High Keratinolytic Activity and Antimicrobial Potential

Protective Effect of Thyme and Chestnut Honeys Enriched with Bee Products against Benzo(a)pyrene-Induced DNA Damage

Can egg yolk antibodies terminate the CSBV infection in apiculture?

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