“…By substituting the two‐chamber model into Equation (4), the objective function for solving metabolic parameters is as follows [20–22]: where and are zero‐time intercepts, and are the rate constants for dye influx and disappearance [23], , , , and are regularization parameters, which is automatically determined by L‐curve [24]. The solution of metabolic parameters by DFMT is the process of determining these four parameters in biological tissues.…”